The Association between Childhood Adversity and Components of Metabolic Syndrome in Adults with Mood Disorders: Results from the International Mood Disorders Collaborative Project

Abstract

The results herein provide preliminary evidence suggesting that childhood adversity is associated with metabolic syndrome components in individuals with mood disorders.

Childhood adversity and metabolic outcomes in adults with mood disorders

“…This study extends the only other previous findings (McIntyre et al, 2012) both methodologically and analytically in this field of research of childhood adversity, metabolic disturbance, and mood disorder. First, we used the SCID, a gold standard instrument that incorporates clinical judgment for diagnosing psychiatric disorders.…”

“…This study found that in a clinical population of mood disorders, individuals who experienced any form of childhood adversity had higher blood pressure and individuals who experienced childhood sexual abuse had higher rates of obesity (McIntyre et al, 2012). Despite these findings, several limitations do exist.…”

“…childhood adversity may mediate the association between mood disorders and metabolic disturbances (McIntyre et al, 2012).…”

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

“…[165][166][167][168] In samples of clinically depressed adults, the prevalence of MetS and low-grade inflammation is significantly higher among those who were exposed to childhood adversities, including maltreatment, than among those who were not. 109,169,170 With regard to vascular outcomes, lifetime rates of stroke, myocardial infarction, and other forms of CVD are elevated among people who report having been maltreated as children. 109,171,172 However, many of the studies on this topic have used retrospective and unconfirmed reports of maltreatment, which complicates interpretation of their results.…”

Long-Term Adaptive Changes Induced by Antidepressants: From Conventional to Novel Therapies

“…In the USA, 59% of MDD patients experience severe degree of functional impairment, making depression the largest contributor to work loss [3,4]. Furthermore, MDD was strongly associated to self-perceived stress, childhood adversity, working status and quality of life [5][6][7]. According to the estimation results reported in the global burden of disease study (a study measuring disability-adjusted life-years, DALY), MDD will have become the leading cause of disability in developed countries by the year 2030 [8], indicating that the situation is not likely to improve unless something changes.…”