The association between CarieScan Pro readings and histologic depth of caries in non cavitated occlusal lesion in vitro

Cohen, Joshua E.

doi:10.17077/etd.3t6xto3n

Cited by 3 publications

(7 citation statements)

References 39 publications

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“…The greater difference between test and control lesions, however, occurred in the impedance values compared with that in the morphometric measurements, thereby confirming that SAP P 11 -4 acts predominantly by regenerating the mineral structure of the enamel of the lesion body and not just the surface 23,24 . Moreover, at the last study visit at day 180, the impedance values for test lesions indicated regression of caries into very outer enamel, whereas the impedance values for the control lesions indicated still caries throughout the whole enamel layer 31,33 , which agrees with previous data that fluoride (in the present study as fluoride-based professional prophylaxis paste and home care toothpaste) only acts in the top 30-50 µm of the enamel surface 13,14,34 .…”

Section: Discussionsupporting

confidence: 92%

“…Orthodontic WSL are of particular interest for clinical investigations of caries in this respect, as they are assumed to be active until debonding of the brackets, whereupon they become inactive 4,8 and good accessible for several measurement methods 16,29 .Therefore, the present split-mouth study investigated the effect of SAP P 11 -4 in addition to the conventional treatment of early carious lesions after debonding of orthodontic brackets. The primary endpoint was the impedance measurement [29][30][31] . Moreover, a semi-automated approach to measure the WSL size was used as done in other clinical studies on SAP P 11 -4 25-27 .…”

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confidence: 99%

“…Therefore, the present split-mouth study investigated the effect of SAP P 11 -4 in addition to the conventional treatment of early carious lesions after debonding of orthodontic brackets. The primary endpoint was the impedance measurement [29][30][31] . Moreover, a semi-automated approach to measure the WSL size was used as done in other clinical studies on SAP P 11 -4 25-27 .…”

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confidence: 99%

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Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions

Welk

Ratzmann

Reich

et al. 2020

Sci Rep

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This study aimed to evaluate the effect of self-assembling peptide P 11 -4 (SAP) in the therapy of initial smooth surface caries (white spot lesions, WSL) following orthodontic multibracket treatment. Twentythree patients (13f/10m; average age 15.4 years) with at least two teeth with WSL were recruited for the randomised controlled clinical trial with split-mouth design. In opposite to the control teeth, the test teeth were treated with SAP on Day 0. The primary endpoint was the impedance measurement of WSL using customised tray to ensure reproducibility of the measurement location. The secondary endpoint was the morphometric measurement of WSL using a semi-automated approach to determine the WSL size in mm 2 . Treatment effects were adjusted for site-specific baseline values using mixed models adapted from the cross-over design. Test WSL showed a mean baseline impedance value of 46.7, which decreased to 21.1, 18.4, and 19.7 after 45, 90, and 180 days, respectively. Control WSL showed a mean baseline value of 42.0, which decreased to 35.0, 29.5, and 33.7, respectively. The overall treatment contrast was −13.7 (95% CI: −19.6 -−7.7; p < 0.001). For the secondary endpoint, the test WSL size decreased from 8.8 at baseline to 6.5 after 180 days. The control WSL decreased from 6.8 to 5.7, respectively. The related treatment contrast was −1.0 in favour of test WSL (95% CI: −1.6 -−0.5; p = 0.004). The treatment of initial carious lesions with self-assembling peptide P 11 −4 leads to superior remineralisation of the subsurface lesions compared with the control teeth.Orthodontic treatments with fixed multibracket appliances hindering oral hygiene, support plaque accumulation, and caries progression 1,2 . These orthodontic treatment-induced carious lesions are typically visible first as so-called white spot lesions (WSL) on the buccal surface of the tooth outlining the brackets 3-6 .Modern treatment concepts for caries emphasise tooth preservation and remineralisation concepts especially for initial non-cavitated carious lesions, in order to hinder or to delay the first invasive intervention, meaning destruction of the natural tooth structure 7 .Unique for buccal WSL is the addition of an aesthetic component to the cariological issue 3,8 . Fluorides prevent the formation of so-called white spot lesions (WSL) but have shown little effect on the reduction of existing WSL 9-11 . As their effect is restricted to the outer surface layer of the enamel (i.e. top 50 µm) and does not promote the remineralisation throughout the demineralised lesion body. The WSL persist visually almost unchanged 12-14 . Other remineralisation agents, often based on calcium phosphate, have been investigated, but could not show clinically significant advantage over fluoride 10,11,[15][16][17] .As a consequence, new treatment approaches have been called for and biomimetic mineralisation seems to be one promising possibility [18][19][20][21][22] . However, the only clinically available products at present are based on the self-assembling peptide P 11 -4 ...

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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confidence: 99%

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Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions

Welk

Ratzmann

Reich

et al. 2020

Sci Rep

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“…International Caries Detection and Assessment System -ICDAS is such a system. Many authors emphasize the appropriateness of this method in the diagnosis of dental caries: the stage and extent of the lesions, as well as high repeatability of the results obtained by ICDAS [1,4,16]. Ari T and Ari N., [1] note the high importance of LED lighting and magnification in improving the accuracy of diagnosis when assessing the tooth surface using the ICDAS index.…”

Section: Discussionmentioning

confidence: 99%

“…Many authors showed the impact on the differences in the results of studies of the so-called cut-off point in a clinical and visual method using ICDAS. According to them, in a study conducted in vitro on permanent extracted teeth, the increase in cut-off point from 2 to 3 reduces the sensitivity of the method, while at the same time increases its specificity [4,16].…”

Section: Discussionmentioning

confidence: 99%

Comparison of visual, impedance spectroscopy and laser fluorescence methods in detecting early carious lesions on occlusal surfaces

Chałas

Wójcik-Chęcińska

Zubrzycka-Wróbel

et al. 2014

Current Issues in Pharmacy and Medical Sciences

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The diagnostic management is a very important and integral part of the entire treatment process and has a direct influence on the decision-taking on the choice of the most appropriate form of therapy consistent with current knowledge. Knowledge of the morphology of hard dental tissues lesions has led to the development of quantitative methods for diagnosis and monitoring of dental caries, which enabled the implementation of appropriate treatments aimed at repairing than replacing damaged tissue. The aim of the study was to compare selected diagnostic methods: visual (ICDAS), impedance spectroscopy (CarieScan PRO) and laser fluorescence (Diagnodent Pen) in detecting caries in grooves on the chewing surfaces of molars and premolars. The obtained results indicated a high concordance of measurements performed with the Diagnodent Pen with the results of visual examination and a lower compliance of visual examination with the results obtained using the CarieScan PRO. A combination of visual and tactile method with tests using advanced technology provides greater opportunity to confirm the diagnosis of carious lesions requiring medical intervention.

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Reliability of impedance spectroscopy versus digital radiograph and ICDAS-II in occlusal caries detection: a prospective clinical trial

R. AbdELkader,

Hafez Ibrahim,

Elsayed Hassanein

2024

Sci Rep

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The traditional methods in early caries detection had many limitations. So, this study aimed to evaluate the clinical performance of alternating current impedance spectroscopy ACIST in comparison with digital radiograph and ICDAS-II in detection of occlusal carious lesions. Occlusal surfaces of molar and premolar teeth from 40 adult participants were examined by two observers using three diagnostic methods: (1) international caries detection and assessment system (ICDAS-II) (2) digital radiograph (DR) and (3) Cariescan Pro device (ACIST). Agreement analysis and the difference in sensitivities and specificities were evaluated. The results showed an excellent agreement in the different groups. The difference from the visual tactile against ACIST scoring for enamel caries detection, was statistically significant (p = 0.012) and the agreement was moderate (k = 0.509). For dentinal caries the difference was not statistically significant (p > 0.05) and the agreement was similarly moderate (k < 0.6). The difference from the digital radiograph against ACIST scoring, for enamel caries, digital radiography had significantly higher sensitivity and specificity than ACIST (p < 0.001) while for dentinal caries detection and overall, ACIST had higher sensitivity and digital radiography had higher specificity and the difference was statistically significant (p < 0.001). Visual-tactile examination is a considered as feasible and valid technique for occlusal caries detection, digital radiography is superior to ACIST in diagnosing enamel caries, but it could underestimate the caries depth, ACIST is a reliable tool for detecting occlusal caries in dentin.

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The association between CarieScan Pro readings and histologic depth of caries in non cavitated occlusal lesion in vitro

Cited by 3 publications

References 39 publications

Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions

Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions

Comparison of visual, impedance spectroscopy and laser fluorescence methods in detecting early carious lesions on occlusal surfaces

Reliability of impedance spectroscopy versus digital radiograph and ICDAS-II in occlusal caries detection: a prospective clinical trial

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