The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences

Naji, Leen; Rosic, Tea; Dennis, Brittany B.; Bhatt, Meha; Sanger, Nitika; Hudson, J.L.; Mouravska, Natalia; Thabane, Lehana; Samaan, Zainab

doi:10.1186/s13293-018-0182-x

Cited by 9 publications

(13 citation statements)

References 33 publications

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“…This prevalence in those with OCS is interesting, given that psychosis, but not OCD, has been strongly associated with use of or dependence on cannabis (45). Such an association has been found for other psychiatric disorders, including depression, anxiety, and suicide attempts, and for psychosis manifested at earlier ages (45)(46)(47)(48). We do not, however, know of its effect on OCS or on the development of psychosis.…”

Section: Discussionmentioning

confidence: 90%

Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample

et al. 2021

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Recent studies suggest that the endocannabinoid system could play an important role in the physiopathology of obsessive-compulsive disorder (OCD). There are reports of effective treatment with derivatives of tetrahydrocannabinol (THC). The study of the genetic factor associated with psychiatric disorders has made possible an exploration of its contribution to the pharmacological response. However, very little is known about the genetic factor or the prevalence of cannabis use in the Mexican population with OCD. The objective of this study is to compare the prevalence of use and dependence on cannabis in individuals with obsessive-compulsive symptomatology (OCS) with that of individuals with other psychiatric symptoms (psychosis, depression, and anxiety), and to explore the association between genetic risk and use. The study includes a total of 13,130 individuals evaluated in the second stage of the 2016 National Survey of Drug, Alcohol, and Tobacco Use (Encodat 2016), with genetic analysis (polygenic risk scoring) of a subsample of 3,521 individuals. Obsessive symptomatology had a prevalence of 7.2% and compulsive symptomatology a prevalence of 8.6%. The proportion of individuals with OCS who had ever used cannabis was 23.4%, and of those with cannabis dependency was 2.7%, the latter figure higher than that in individuals with other psychiatric symptoms (hypomania, 2.6%; anxiety, 2.8%; depression, 2.3%), except psychosis (5.9%). Individuals with OCS who reported using cannabis had an increased genetic risk for cannabis dependence but not for OCD. We thus cannot know how the increased genetic risk of cannabis dependence in people with OCD is influenced by their pharmacological response to derivatives of THC. The results, however, suggest paths for future studies.

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Section: Discussionmentioning

confidence: 90%

Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample

et al. 2021

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“…These characteristics are commonly adjusted for in the literature, and were chosen due to their clinical relevance or possible confounding. 13 – 16 Goodness of fit was assessed using the Hosmer-Lemeshow test and McFadden's pseudo R 2 . 17 , 18 …”

Section: Methodsmentioning

confidence: 99%

“…Our team has previously shown that amongst a different sample of patients with psychiatric comorbidities, more frequent cannabis use was associated with a higher risk of suicide attempt in men, but not women. 13 We measured frequency of cannabis use as a binary variable, categorized into daily use or less than daily use. All analyses were performed using STATA version 13.0.…”

Section: Methodsmentioning

confidence: 99%

The Role of Cannabis Use in Suicidal Ideation Among Patients With Opioid Use Disorder

Naji

Rosic

Sanger

et al. 2020

Journal of Addiction Medicine

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Objectives: Cannabis use is associated with suicide risk in the general population; however, it is unknown if this association is also present in patients with opioid use disorder (OUD). The purpose of this study is to investigate the association between cannabis use and suicidal ideation in patients with OUD. Methods: We conducted a multivariable logistic regression analysis to assess the association between cannabis use and suicidal ideation, amongst a large cohort of patients with OUD. Current cannabis use and suicidal ideation over the past 30 days were obtained by self-report. Results: Cross-sectional data from 2335 participants with OUD were included in the analysis, of whom 51% report current cannabis use. We found a positive association between cannabis use and suicidal ideation (OR = 1.41, 95% CI 1.11, 1.80, P = 0.005). We found that men (OR = 1.84, 95% CI 1.44, 2.35, P < 0.001), younger individuals (OR = 1.02, 95% CI 1.01, 1.03), P = 0.004), and that those with more symptoms of anxiety or depression (OR = 1.16, 95% CI 1.15, 1.18, P < 0.001) were more likely to report suicidal ideation. Conclusions: Cannabis use is associated with a heightened propensity for suicidal ideation amongst patients with OUD, who are already a high-risk population. Further research into the potential harms of cannabis use in this population is required given the prevalence of its use and potential benefits in mitigating opioid withdrawal.

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“…However, a longitudinal study conducted in 2009 found no increase in suicide completion in cannabis users [101], and an additional meta-analysis of the literature conducted in 2016 reported no clear evidence to support cannabis use as a risk factor for suicidality [102]. In addition, cannabis users with pre-existing depression may experience increased suicidal ideation [103], although conflicting findings showing no increase in suicidal ideation have also been reported [104]. Similar to the findings in individuals with pre-existing anxiety, cannabis use in patients with preexisting depression is associated with worse recovery of symptoms and outcomes [105].…”

Section: Association With Anxiety and Depressionmentioning

confidence: 99%

An overview of the adverse effects of cannabis use for Canadian physicians

Leduc‐Pessah

Jensen²,

Newell

2019

CIM

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Purpose: Cannabis is the most widely used illicit substance and one of the most commonly used psychoactive substances in the world, preceded only by alcohol, tobacco and caffeine. Recent changes in legislation regarding cannabis use in Canada and potential upcoming changes worldwide may have a further impact on the prevalence of cannabis use. Thus, it is critical to understand the risks and potential adverse health effects of acute and long-term cannabis use. Current literature is lacking in many areas surrounding cannabis use, and for the most part is unable to provide clear associations once confounding variables are considered. Here we provide a general overview of the history of cannabis, the physical and mental health consequences, and the risks to specific groups. Source: A scoping search of published articles in PubMed from the start date (1946) until 2018. Principal finding: Current evidence supports an association between cannabis use and mild respiratory and cardiac effects, but no clear increased risk of cancer. Psychiatric disorders, including schizophrenia and anxiety, show associations with cannabis use; however, a causal effect of cannabis use is unclear. While no evidence for increased risk in pregnancy has been found, risk is still undetermined. Youth may be at a greater risk as earlier initiation of use increases the risk of adverse health effects. Conclusion: Overall, evidence for direct and long-term adverse effects of cannabis use is minimal and additional longitudinal studies will be required to better delineate unidentified effects.

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The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences

Cited by 9 publications

References 33 publications

Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample

Cannabis Use in People With Obsessive-Compulsive Symptomatology: Results From a Mexican Epidemiological Sample

The Role of Cannabis Use in Suicidal Ideation Among Patients With Opioid Use Disorder

An overview of the adverse effects of cannabis use for Canadian physicians

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