The association between cadmium exposure and chronic airflow limitation and emphysema: the Swedish CArdioPulmonary BioImage Study (SCAPIS pilot)

Olin, Anna‐Carin; Johnsson, Åse A.; Vikgren, Jenny; Forsgard, Niklas; Bergström, Göran; Sällsten, Gerd; Barregård, Lars

doi:10.1183/13993003.00960-2019

Cited by 8 publications

(9 citation statements)

References 11 publications

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“…Cd and lead (Pb) co-exposure resulted in reduced FEV1 and FVC in children living in e-waste recycling area ( Zeng et al, 2017 ). Similar associations between blood Cd and forced vital capacity (FVC), FEV1, FEV1/FVC, peak expiratory force (PEF) were shown in welders ( Cetintepe et al, 2019 ; Torén et al, 2019 ). Even upon low Cd body burden in exposed workers, urinary Cd levels were associated with higher prevalence of subjective respiratory symptoms despite the lack of significant changes in lung function ( Li et al, 2020 ).…”

Section: Introductionmentioning

confidence: 53%

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Skalny

Lima

Tao

et al. 2020

Food and Chemical Toxicology

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Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for CO rona VI rus D isease 2019 (COVID-19) susceptibility and severity. Taking into account the high level of toxic metals in both particulate matter (PM2.5) and tobacco smoke, the objective of this review is to discuss recent data on the role of heavy metal exposure in development of respiratory dysfunction, immunotoxicity, and severity of viral diseases in epidemiological and experimental studies, as to demonstrate the potential crossroads between heavy metal exposure and COVID-19 severity risk. The existing data demonstrate that As, Cd, Hg, and Pb exposure is associated with respiratory dysfunction and respiratory diseases (COPD, bronchitis). These observations corroborate laboratory findings on the role of heavy metal exposure in impaired mucociliary clearance, reduced barrier function, airway inflammation, oxidative stress, and apoptosis. The association between heavy metal exposure and severity of viral diseases, including influenza and respiratory syncytial virus has been also demonstrated. The latter may be considered a consequence of adverse effects of metal exposure on adaptive immunity. Therefore, reduction of toxic metal exposure may be considered as a potential tool for reducing susceptibility and severity of viral diseases affecting the respiratory system, including COVID-19.

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Section: Introductionmentioning

confidence: 53%

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Skalny

Lima

Tao

et al. 2020

Food and Chemical Toxicology

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“…Cadmium was associated with respiratory malfunction, decreased lung function, and respiratory diseases such as COPD and bronchitis [ 17 , 30 , 31 , 32 , 33 ]. Furthermore, Oh et al [ 34 ] detected an increasing prevalence of COPD associated with Cd in men, but not in women.…”

Section: Resultsmentioning

confidence: 99%

“…To determine a real clinical COPD, the studies selected in this review used spirometry in the examination of pulmonary outcomes (FEV 1 , forced vital capacity—FVC, and FEV 1 /FVC), and some articles, additionally, self-reported COPD, symptoms of chronic bronchitis [ 15 , 16 ], or emphysema on computed tomography (CT) scan [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Environmental Substances Associated with Chronic Obstructive Pulmonary Disease—A Scoping Review

Elonheimo

Mattila

Andersen

et al. 2022

IJERPH

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Chronic obstructive pulmonary disease (COPD) is a slowly developing non-communicable disease (NCD), causing non-reversible obstruction and leading to marked morbidity and mortality. Besides traditional risk factors such as smoking, some environmental substances can augment the risk of COPD. The European Human Biomonitoring Initiative (HBM4EU) is a program evaluating citizens’ exposure to various environmental substances and their possible health impacts. Within the HBM4EU, eighteen priority substances or substance groups were chosen. In this scoping review, seven of these substances or substance groups are reported to have an association or a possible association with COPD. Main exposure routes, vulnerable and high-exposure risk groups, and matrices where these substances are measured are described. Pesticides in general and especially organophosphate and carbamate insecticides, and some herbicides, lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) showed an association, and cadmium (Cd), chromium (Cr and CrVI), arsenic (As), and diisocyanates, a possible association with COPD and/or decreased lung function. Due to long latency in COPD’s disease process, the role of chemical exposure as a risk factor for COPD is probably underestimated. More research is needed to support evidence-based conclusions. Generally, chemical exposure is a growing issue of concern, and prompt action is needed to safeguard public health.

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“…A higher blood cadmium level, within the normal range, was associated with COPD prevalence in males, including those who had never smoked. Cadmium exposure, even in the low-dose range, is a risk factor for emphysema [28]. A large nationally representative sample of the US population demonstrated a significant association between serum cadmium concentration and obstructive lung disease.…”

Section: Discussionmentioning

confidence: 98%

Blood Cadmium Levels and Oxygen Desaturation during the 6-Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease

et al. 2021

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Background and Objectives: chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and a history of exposure to noxious stimuli. Cigarette smoking is the most important causal factor for developing COPD. Cadmium, a minor metallic element, is one of the main inorganic components in tobacco smoke. Inhaled cadmium was associated with a decline in lung function, gas exchange impairment, and the development of obstructive lung disease. Patients with COPD who had oxygen desaturation during the 6-min walk test (6MWT) had a significantly worse prognosis than non-desaturation in COPD patients. Nonetheless, few studies have addressed the influence of blood cadmium levels on exercise-induced oxygen desaturation in COPD patients. Our objective was to assess the potential impact of blood cadmium levels on oxygen desaturation during the 6MWT among COPD patients. Materials and Methods: we performed a retrospective analysis of patients with COPD who were examined for blood cadmium levels in a tertiary care referral center in Taiwan, between March 2020 and May 2021. The 6-min walk test was performed. Normal control subjects who had no evidence of COPD were also enrolled. Results: a total of 73 COPD patients were analyzed and stratified into the high-blood cadmium group (13 patients) and low-blood cadmium group (60 patients). A total of 50 normal control subjects without a diagnosis of COPD were enrolled. The high-blood cadmium group had a significantly higher extent of desaturation than the low-blood cadmium group. The frequency of desaturation during 6MWT revealed a stepwise-increasing trend with an increase in blood cadmium levels. A multivariable logistic regression model revealed that blood cadmium levels were independently associated with desaturation during the 6MWT (odds ratio 12.849 [95% CI 1.168–141.329]; p = 0.037). Conclusions: our findings indicate that blood cadmium levels, within the normal range, were significantly associated with desaturation during 6MWT in patients with COPD.

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The association between cadmium exposure and chronic airflow limitation and emphysema: the Swedish CArdioPulmonary BioImage Study (SCAPIS pilot)

Cited by 8 publications

References 11 publications

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases

Environmental Substances Associated with Chronic Obstructive Pulmonary Disease—A Scoping Review

Blood Cadmium Levels and Oxygen Desaturation during the 6-Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease

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