The Association between Branched-Chain Amino Acids (BCAAs) and Cardiometabolic Risk Factors in Middle-Aged Caucasian Women Stratified According to Glycemic Status

Kubacka, Justyna; Cembrowska, Paulina; Sypniewska, Grażyna; Stefańska, Anna

doi:10.3390/nu13103307

Cited by 11 publications

(11 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to a recent study conducted in Poland to evaluate the prevalence of dyslipidemia in the adult population, elevated triglyceride levels (>150 mg/dL) were observed in 31% of men and 20% of women [17], while in our study, this proportion was almost the same, with hypertriglyceridemia present in 29.4% of men and 19.7% of women. We did not assess either thyroid function or insulin resistance in our study; however, referring to recent data from our group, we may assume that most of the subjects were euthyroid [19]. Moreover, in our study, both females and males had similar glycemic status according to HbA1c values.…”

Section: Discussionmentioning

confidence: 74%

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity

et al. 2021

Self Cite

View full text Add to dashboard Cite

Hypertriglyceridemia is an independent risk factor for coronary artery disease. Lipoprotein lipase (LPL) plays an essential role in the metabolism of triglyceride-rich lipoproteins (TRLs). Angiopoietin-like proteins ANGPTL3 and ANGPTL8 are shown to be important regulators of LPL activity. Increased concentrations of these proteins may reflect cardiovascular risk, and the treatment of patients with dyslipidemia with ANGPTLs inhibitors may decrease this risk. We assessed the gender-specific relationships of serum ANGPTL3 and ANGPTL8 with atherogenic lipid biomarkers and obesity in non-diabetic adults. The study comprised 238 participants aged 25–74 [122 with triglycerides (TG) <150 mg/dL (<1.7 mmol/L) and 116 with hypertriglyceridemia]. Total cholesterol, HDL-cholesterol, LDL-cholesterol, TG, C-reactive protein (CRP), glycated hemoglobin, apolipoprotein B, small dense LDL-C (sd-LDL-C), ANGPTL3, and ANGPTL8 were measured. Non-HDL-cholesterol, remnant cholesterol (remnant-C) concentrations, and body mass index (BMI) were calculated. Results: Women and men did not differ in terms of age, CRP levels, the percentage of obese subjects, and concentrations of atherogenic lipid biomarkers, except higher TG in males and higher ANGPTL3 concentrations in females. Positive correlations of both ANGPTLs with TG, remnant-C, and sdLDL-C levels were found in females. In males, only ANGPTL3 correlated positively with atherogenic biomarkers, but there were no correlations with ANGPTL8. Concentrations of ANGPTL3 were higher in obese men, whereas ANGPTL8 levels were higher in obese women. In women alone, ANGPTL8 showed very good discrimination power to identify subjects with hypertriglyceridemia (AUC = 0.83). Contrary to this, ANGPTL3 was a better discriminator of hypertriglyceridemia (AUC = 0.78) in male subjects. Regression models, adjusted for age, sex, and BMI showed a weak but significant effect of ANGPTL8 to increase the risk of hypertriglyceridemia. Conclusions: In females, ANGPTL8 is more strongly associated with TRLs metabolism, whereas in males, ANGPTL3 plays a more important role. We suggest sex differences be taken into consideration when applying new therapies with angiopoietin-like proteins inhibitors in the treatment of dyslipidemia.

show abstract

Section: Discussionmentioning

confidence: 74%

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…We believe this does not affect our results at first, as in our study the borderline correlation of ANGPTL3 with TG/HDL-C ratio was observed only in POST women (p = 0.055), secondly as the cut-off point for this ratio which may vary depending on the glycemic status [27] was similar in PRE and POST cases. We did not assess insulin resistance but, referring to our previous study in which both, TG/HDL-C index and HOMA-IR (the homeostasis model assessment-estimated insulin resistance) were calculated, it is safe to assume that in most women HOMA-IR was within the reference range [28]. Moreover, recent review articles reported that insulin does not alter ANGPTL8 levels in the circulation [9] and that the association of ANGPTL8 with insulin resistance and HbA1c in non-diabetic subjects seems contentious [29].…”

Section: Discussionmentioning

confidence: 99%

Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women

et al. 2022

Self Cite

View full text Add to dashboard Cite

Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships between serum ANGPTL3 and ANGPTL8 and atherogenic biomarkers in presumably healthy women during ageing. The study group included 94 women of whom 31 were premenopausal (PRE ≤ 40 years) and 37 were postmenopausal (POST ≥ 52 years). Atherogenic lipid and non-lipid biomarkers and ANGPTLs (ANGPTL3, ANGPTL8) were assayed in serum samples. TG/HDL-C index, non-HDL-cholesterol, remnant cholesterol concentrations, and BMI were calculated. Median levels of ANGPTL3 and concentrations of lipid biomarkers were significantly higher in POST comparing to PRE but ANGPTL8 levels were not different. In PRE, ANGPTL8 levels correlated significantly with TG and TG/HDL-C index while there were no correlations between ANGPTL3 and these biomarkers. In POST both ANGPTLs correlated with TG, sdLDL-C, and TG/HDL-C. ANGPTL8 and sd-LDL-C were the most significant predictors of early triglyceride elevation > 100 mg/dL (1.13 mmol/L) in the whole group and POST whereas the prediction power of ANGPTL3 was negligible in the whole group and non-significant in the subgroups. We demonstrated a significant positive correlation of ANGPTL3 with age category which predisposes to postmenopause. Despite the increase in ANGPTL3 level with ageing the ANGPTL3/ANGPL8 ratio was maintained. In conclusion, ANGPTL8 predicts the early triglyceride elevation better than ANGPTL3, especially in postmenopausal women. The association of ANGPTL3 with triglyceride levels is weaker than ANGPTL8 and depends on menopausal status. We suggest that the choice for the best efficient treatment of dyslipidemia with new inhibitors of angiopoietin-like proteins may depend on the menopausal status.

show abstract

“…Fasting venous blood samples were collected in the early morning for all parameters. The parameters of triglycerides (TG), HDL-cholesterol (HDL-C), creatinine, CRP, alanine aminotransferase (ALT), gamma glutamyltransferase (GGT), insulin, and TSH were measured in the serum, while the plasma was used for glucose measurement, and EDTA whole blood was used to determine glycated hemoglobin (HbA1c) as previously described [50]. The HOMA-IR value was calculated [51].…”

Section: Blood Sampling and Laboratory Analysesmentioning

confidence: 99%

The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes

et al. 2022

Self Cite

View full text Add to dashboard Cite

We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women. The study included 128 obese women divided into two subgroups: a normoglycemic group (NG, n = 65) and a T2D group (n = 63). The concentrations of serum tryptophan (Trp), kynurenine (Kyn), 3-hydroxykynurenine (3HKyn), quinolinic acid (QA), and kynurenic acid (Kyna) were analyzed using ultra-high-performance liquid chromatography coupled with electrospray ionization/triple quadrupole mass spectrometry. Blood biochemical parameters and anthropometric parameters were measured. The women with T2D had significantly higher Trp, Kyna, Kyna/QA ratio, and Kyna/3HKyn ratio values than the NG women. Logistic regression analysis showed that the concentrations of Trp and Kyna and the values of the Kyna/3HKyn ratio were most strongly associated with T2D occurrence, even after controlling for confounding factors. The model with Trp level and Kyna/3HKyn ratio accounted for 20% of the variation in the presence of T2D. We also showed a different pattern of correlations between kynurenines and metabolic factors in the NG and T2D women, which was mostly reflected in the stronger relationship between BMI and KP metabolites in the NG obese women. An increase in Trp and Kyna levels with an accompanying increase in Kyna/3HKyn ratio value is associated with the occurrence of T2D in obese middle-aged women.

show abstract

The Association between Branched-Chain Amino Acids (BCAAs) and Cardiometabolic Risk Factors in Middle-Aged Caucasian Women Stratified According to Glycemic Status

Cited by 11 publications

References 93 publications

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity

Relationship between Serum Angiopoietin-like Proteins 3 and 8 and Atherogenic Lipid Biomarkers in Non-Diabetic Adults Depends on Gender and Obesity

Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women

The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes

Contact Info

Product

Resources

About