2018
DOI: 10.1002/brb3.1020
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Abstract: IntroductionWe present the Brain‐Age Score (BAS) as a magnetic resonance imaging (MRI)‐based index for Alzheimer's disease (AD). We developed a fully automated framework for estimating the BAS in healthy controls (HCs) and individuals with mild cognitive impairment (MCI) or AD, using MRI scans.MethodsWe trained the proposed framework using 385 HCs from the IXI and OASIS datasets and evaluated 146 HCs, 102 stable‐MCI (sMCI), 112 progressive‐MCI (pMCI), and 147 AD patients from the J‐ADNI dataset. We used a corr… Show more

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Cited by 53 publications
(65 citation statements)
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“…The significant correlations between chronological age and brain-predicted age in all three external datasets shows that our model is accurate and generalizable (0.65, 0.78, and 0.87 for external datasets). Although the magnitude of these correlations is lower than correlations reported elsewhere, ranging from 0.91 to 0.94 (Cole et al, 2015;Cole, Poudel, et al, 2017;Franke et al, 2010;Lancaster et al, 2018;Liem et al, 2017), it exceeds other externally validated brain-predicted age studies, ranging from 0.65 to 0.85 (Beheshti et al, 2018;Madan & Kensinger, 2018;Varikuti et al, 2018).…”
Section: Model Evaluationcontrasting
confidence: 79%
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“…The significant correlations between chronological age and brain-predicted age in all three external datasets shows that our model is accurate and generalizable (0.65, 0.78, and 0.87 for external datasets). Although the magnitude of these correlations is lower than correlations reported elsewhere, ranging from 0.91 to 0.94 (Cole et al, 2015;Cole, Poudel, et al, 2017;Franke et al, 2010;Lancaster et al, 2018;Liem et al, 2017), it exceeds other externally validated brain-predicted age studies, ranging from 0.65 to 0.85 (Beheshti et al, 2018;Madan & Kensinger, 2018;Varikuti et al, 2018).…”
Section: Model Evaluationcontrasting
confidence: 79%
“…With respect to mean absolute error (MAE), our model did not perform as well as other externally validated studies, ranging from 4.28 to 7.5 years (Beheshti et al, 2018;Cole, Ritchie, et al, 2018;Franke et al, 2010;Lancaster et al, 2018;Madan & Kensinger, 2018).…”
Section: Model Evaluationcontrasting
confidence: 72%
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“…While there is no exact definition for accelerated brain aging, BrainAGE score has been shown to be a sensitive predictor of disease progression in dementia 2729 . Previous findings on increased BrainAGE score in MCI and AD course 6769 , are in agreement with the reported accelerated aging of the demented brain shown in-vivo and ex-vivo studies 70 . The BrainAGE score in studies using ADNI ranged from almost zero for patients with stable MCI, to 5.7–6.2 years for patients with progressive MCI, and reached up to 10 years for patients with AD 27 .…”
Section: Discussionsupporting
confidence: 89%