The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies

Abstract

Obesity has been associated with increased risk of adult asthma, however, not all studies have found a clear association between overweight and the incidence of asthma, and data on other adiposity measures have been limited. Hence, we aimed to summarize evidence on association between adiposity and adult asthma. Relevant studies were retrieved through searches conducted in PubMed, and EMBASE up to March 2021. A total of sixteen studies (63,952 cases and 1,161,169 participants) were included in the quantitative synthesis. The summary RR was 1.32 (95% CI 1.21–1.44, I2 = 94.6%, pheterogeneity < 0.0001, n = 13) per 5 kg/m2 increase in BMI, 1.26 (95% CI 1.09–1.46, I2 = 88.6%, pheterogeneity < 0.0001, n = 5) per 10 cm increase in waist circumference and 1.33 (95% CI 1.22–1.44, I2 = 62.3%, pheterogeneity= 0.05, n = 4) per 10 kg increase in weight gain. Although the test for nonlinearity was significant for BMI (pnonlinearity < 0.00001), weight change (pnonlinearity = 0.002), and waist circumference (pnonlinearity = 0.02), there was a clear dose-response relationship between higher levels of adiposity and asthma risk. The magnitude of the associations and the consistency of the results across studies and adiposity measures provide strong evidence that overweight and obesity, waist circumference and weight gain increases asthma risk. These findings support policies to curb the global epidemic of overweight and obesity.

Obesity is Associated with Increased Risk of New‐Onset Chronic Rhinosinusitis: A United States Population‐Based Cohort Study

“…30 While our results, in combination with recent Meta-analyses, indicate an association between obesity and respiratory diseases like asthma and CRS, it appears obesity may not be associated with the development of systemic vasculitis as seen in patients with EGPA. 31,32 Although not a small-vessel vasculitis, previous research has shown giant cell arteritis, a systemic vasculitis, was negatively associated with obesity. For these reasons, it may be possible that obesity does not play a role in the development of the small-vessel vasculitis seen in patients with EGPA, and further research on this topic is needed.…”

The Association between the Body Mass Index, Chronic Obstructive Pulmonary Disease and SUV of the Non-Tumorous Lung in the Pretreatment [18F]FDG-PET/CT of Patients with Lung Cancer

“…Conversely, reduced lung tissue density, with more air, leads to decreased SUV values. Additionally, a systemic chronic inflammatory response often associated with higher BMI levels might have contributed to the correlation between the BMI and the lung SUV [ 35 , 36 , 37 ]: an elevated BMI has been linked to increased levels of pro-inflammatory cytokines and adipokines, which could potentially enhance metabolic activity and inflammation within lung tissue, thereby influencing SUV measurements [ 35 , 36 , 37 ]. However, we also investigated a potential association of diabetes and the pre-therapeutic lung SUV, which is another comorbidity with a known influence on metabolic activity and is associated with chronic inflammatory activity.…”

Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer’s disease – a systematic review and meta-analysis

“…The NOS encompasses three domains: selection (scoring ranging from 0 to 5 for cross-sectional studies and 0 to 4 for cohort and case–control studies), comparability (scoring from 0 to 2), and outcome (scoring from 0 to 3). Depending on the cumulative scores attained, the studies were classified into three distinct groups: those with a very high risk of bias (0 to 3 points), high risk of bias (4 to 6 points), and low risk of bias (7 to 10 points) ( Herzog et al, 2013 ; Parasuaraman et al, 2023 ).…”