The Association between Autoimmunity and Agnogenic Myeloid Metaplasia

Ben-Chétrit, Eldad; Gross, David J.; Okon, Elimelech; Levo, Y

doi:10.1111/j.1600-0609.1983.tb01534.x

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1990

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Cited by 7 publications

(1 citation statement)

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“…Congestive cardiomyopathy owing to amyloid infiltration of the heart has been described (51). Cutaneous manifestations other than those related to haemorrhagic diathesis are rather uncommon (52,53).…”

Section: Clinical Featuresmentioning

confidence: 99%

Idiopathic myelofibrosis: A review

Hasselbalch

1990

European J of Haematology

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Section: Clinical Featuresmentioning

confidence: 99%

Idiopathic myelofibrosis: A review

Hasselbalch

1990

European J of Haematology

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Fine-needle aspiration of large cell lymphoma in a patient with agnogenic myeloid metaplasia: A case report and review of the literature

1998

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Idiopathic myelofibrosis: A clinical study of 80 patients

Hasselbalch

1990

American J Hematol

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A series of 122 consecutive patients with bone marrow fibrosis initially referred or categorized as idiopathic myelofibrosis is described. After a clinical and pathological review 14 patients were classified as postpolycythaemic myelofibrosis and 7 patients as a transitional myeloproliferative disorder. In 13 patients a diagnosis of hairy cell leukaemia was made, 3 patients had malignant lymphoma, 2 had malignant histiocytosis, and 1 patient had systemic lupus erythematosus with myelofibrosis. Two patients were excluded for further analysis owing to insufficient data. In the remaining 80 patients a diagnosis of idiopathic myelofibrosis was made. The clinical and laboratory findings in this series of patients are presented and compared to those in previous series. Infectious, cardiovascular, thromboembolic, and haemorrhagic complications were frequent, being recorded in 63%, 50%, 40%, and 33% of the patients, respectively. Various autoimmune phenomena were found in a proportion of the patients, but none had clinical evidence of connective tissue disease. Fifteen patients (19%) had a syndrome of acute myelofibrosis. The diagnostic criteria for this disease entity and its place within the spectrum of myeloproliferative disorders are discussed. In the present series acute myelofibrosis was found to encompass various transitional stages toward the evolution of acute leukaemia. It is proposed that acute or malignant myelofibrosis is considered as an acute variant of idiopathic myelofibrosis. Within this syndrome the acute variant seems to be far more common than previously recognized, which may also explain the marked clinical heterogeneity of the myelofibrosis/osteomyelosclerosis syndrome in this and most previous series.

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The Association between Autoimmunity and Agnogenic Myeloid Metaplasia

Cited by 7 publications

References 16 publications

Idiopathic myelofibrosis: A review

Idiopathic myelofibrosis: A review

Fine-needle aspiration of large cell lymphoma in a patient with agnogenic myeloid metaplasia: A case report and review of the literature

Idiopathic myelofibrosis: A clinical study of 80 patients

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