The association between attention-deficit/hyperactivity disorder and Atopic dermatitis: A study among Iranian children

Abstract

Background:The co-occurrence of attention-deficit/hyperactivity disorder (ADHD) with atopic dermatitis (AD) has been well described in some recent association studies; however, we did not have any perspective on this relationship in our country.Aim and Objective:Hence, the present study aimed to assess the prevalence of ADHD in children with AD.Materials and Methods:This cross-sectional study was performed on 95 consecutive children and adolescents (aged 4–18 years) who were referred to dermatology clinics at the two hospitals in Tehran during 2017 with atopic dermatitis. The evidence of atopy was assessed using the 2003 National Survey of Children's Health. The diagnosis of ADHD was based on the Conner Rating Scale. The sleep disorder was also assessed by the Pittsburg sleep quality questionnaire.Results:The prevalence of hyperactivity and attention deficit in our AD patients was 20.0% and 29.47%, respectively. Furthermore, patients with sleep problem were significantly more likely to have hyperactivity disorder (odds ratio [OR]: 2.91, 95% confidence interval [CI]: 1.04–8.16, P = 0.04). According to the results of multiple logistic regression analyses, flexor involvement was the only predictor of hyperactivity disorder in the final model. The univariate and multivariate analyses showed that having attention deficit was associated with having cheek involvement (OR = 3.63, 95% CI: 1.44–9.14, P = 0.01) and sleep problem (OR = 3.68, 95% CI: 1.45–9.33, P = 0.01).Conclusion:It seems that neurocognitive disturbances due to sleep restriction in AD children may be one of the main trigger, especially for attention deficit.

Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder

“…Several previous studies did not find significant association between allergic disorders and the development of ADHD 15,17 or ASD, 25,31 . However, most studies that were done in different parts of the world provide evidence for high risk of pediatric allergic patients to develop ADHD 17,24,30,[32][33][34] or ASD 14,17,23,30,34 regardless to the ethnicity of the enrolled patients. A meta-analysis by Schans et al, 26 reported that asthma, rhinitis, and eczema were independent risk factors for ADHD development which is similar to our observation.…”

Early Childhood Allergy Linked With Development of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder

“…Most previous studies investigated the association of a single allergic disorder, [15][16][17][29][30][31][32][33] or up to three allergic comorbidities, 14,23,24,26,28,34,35 and ADHD/ASD. To the best of our knowledge, the present study is the first study which enrolled children with up to six allergic comorbidities (Table 1) including drug allergy that was not previously studied.…”

“…To the best of our knowledge, the present study is the first study which enrolled children with up to six allergic comorbidities (Table 1) including drug allergy that was not previously studied. Moreover, whereas most previous studies reported the association between allergic disorders and ADHD or ASD, 15,16,29,31 we investigated the link to ADHD and ASD (or both ADHD+ASD) using our large pediatric cohort, with the same methodological and statistical analysis that add to the validity of our findings.…”

“…Several previous studies did not find significant association between allergic disorders and the development of ADHD 15,17 or ASD, 25,29 . However, most studies that were done in different parts of the world provide evidence for high risk of pediatric allergic patients to develop ADHD 17,24,28,[30][31][32] or ASD 14,17,23,28,32 regardless to the ethnicity of the enrolled patients. A meta-analysis by Schans et al, 26 reported that asthma, rhinitis, and eczema were independent risk factors for ADHD development which is similar to our observation.…”

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

“…ADHD is the most common neuropsychiatric comorbidity in children with AD [62,63]. A combination of neurological control and treatment of AD symptoms could provide better therapeutic outcomes in these AD patients.…”