The association between asthma and type 1 diabetes: a paediatric case-cohort study in Finland, years 1981–2009

Metsälä, Johanna; Lundqvist, Annamari; Virta, Lauri J.; Kaila, Minna; Gissler, Mika; Virtanen, Suvi Μ.; Nevalainen, Jaakko

doi:10.1093/ije/dyx245

Cited by 30 publications

(42 citation statements)

References 17 publications

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“…A study by Finnish researchers showed that previous diagnosis of asthma increased the risk of subsequent T1DM by 41% (95% CI 1.28-1.54), whereas previous diagnosis of T1DM decreased the risk of subsequent asthma by 18% (95% CI 0.69-0.98). It should be emphasized that these findings were independent of the relevant risk factors, such as age at diagnosis, birth decade, sex, the presence of maternal asthma/DM and birth-related factors [7]. A similar observation was made by Chinese scientists in a group of adults, where besides hypertension, myocardial infarction and ischemic stroke, DM was featured as one of the major diseases coexisting with asthma.…”

Section: Epidemiologysupporting

confidence: 74%

The Coincidence of Diabetes Mellitus and Asthma, Their Probable Causal Relationships and Therapeutic Opportunities

Kosmalski

Różycka-Kosmalska

Pietras

2020

Advances in Respiratory Medicine

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Both the epidemiological data and the everyday medical practice demonstrate the coincidence of various types of diabetes mellitus (DM) in patients with asthma. Specific correlations between the risk of DM in pregnancy, asthma and the consequences of these diseases to the mother and her baby are also explored. The discussion concerning, on the one hand, the impact of asthma-related inflammatory condition on the metabolism of carbohydrates, and, on the other, the presence of chronic hyperglycemia and inflammatory markers observed in patients with asthma, is still ongoing. In the case of asthma and type 1 diabetes mellitus (T1DM), a correlation with the dysfunction of the immune system and the genetic background has been suggested, and in the case of type 2 (T2DM), the vital role of obesity and insulin resistance (IR) to promote excessive proinflammatory immune response. The data indicate that both asthma and DM affect mutually their clinical presentations, including the prognostic values and therapeutic possibilities. The ongoing controversy concerning the effective and safe anti-asthma and hypoglycemizing therapy does not allow for a definitive therapeutic consensus in this group of patients, despite the suggested role of metformin and hyperglycemizing effects of glucocorticoids. Therefore, the objective of the presented paper is a review of the knowledge in the field of DM and asthma coincidence, their probable causal relationships and therapeutic opportunities.

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Section: Epidemiologysupporting

confidence: 74%

The Coincidence of Diabetes Mellitus and Asthma, Their Probable Causal Relationships and Therapeutic Opportunities

Kosmalski

Różycka-Kosmalska

Pietras

2020

Advances in Respiratory Medicine

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“…1 Type 1 diabetes is one of the most common childhood autoimmune diseases, with the incidence rates in Sweden among the highest worldwide. 2 Previous studies have demonstrated positive associations between asthma and type 1 diabetes, [3][4][5][6][7][8][9][10][11] indicating their concomitant occurrence at a population level and individual level and presenting evidence of the importance of the sequential appearance of disease. 7 However, results have been conflicting, and negative associations have also been shown.…”

Section: Introductionmentioning

confidence: 99%

“…2 Previous studies have demonstrated positive associations between asthma and type 1 diabetes, [3][4][5][6][7][8][9][10][11] indicating their concomitant occurrence at a population level and individual level and presenting evidence of the importance of the sequential appearance of disease. 7 However, results have been conflicting, and negative associations have also been shown. 12,13 The range of findings could be explained by heterogeneous methods, including various study designs, inclusion of both children and adults, lack of power, and differing definitions of disease.…”

Section: Introductionmentioning

confidence: 99%

Familial Coaggregation of Asthma and Type 1 Diabetes in Children

et al. 2020

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IMPORTANCE The association between atopic and autoimmune disease, particularly asthma and type 1 diabetes, has been debated. Further understanding of the underlying factors associated with the comorbidity in children is warranted. OBJECTIVES To assess the bidirectional association between asthma and type 1 diabetes and examine the possibility of a shared risk for the diseases by studying their pattern of familial coaggregation.

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“…Considering the Th1/Th2 paradigm (cytokines from either the Th1 or Th2 phenotype exerting suppressive activities on the development and activity of the other phenotype), previous findings have shown a negative association between T1DM and asthma [130][131][132][133]. A recent case-cohort study among Finnish children showed that participants with previously diagnosed asthma were at an increased risk of subsequent development of T1DM but that children with previously diagnosed T1DM presented a decreased risk of subsequent development of asthma, suggesting a distinct interrelation of the sequential appearance of these two diseases [134]. Overall, there is increasing evidence for a positive correlation between the occurrence of T1DM and symptoms of asthma at the population level [135][136][137].…”

Section: Dm and Asthmamentioning

confidence: 99%

Diabetic lung disease: fact or fiction?

Kolahian

Leiss²,

Nürnberg

2019

Rev Endocr Metab Disord

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Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder whose prevalence has been increasing steadily worldwide. Even though little attention has been paid to lung disorders in the context of diabetes, its prevalence has recently been challenged by newer studies of disease development. In this review, we summarize and discuss the role of diabetes mellitus involved in the progression of pulmonary diseases, with the main focus on pulmonary fibrosis, which represents a chronic and progressive disease with high mortality and limited therapeutic options. Keywords Diabetes mellitus. Pulmonary disease. Lung. Fibrosis Abbreviations ALI acute lung injury ARDS acute respiratory distress syndrome AGE advanced glycation end product ASMs airway smooth muscle cells ASL airway surface liquid CO carbon monoxide COPD chronic obstructive pulmonary disease CTGF connective tissue growth factor CFRD cystic fibrosis-related diabetes DM diabetes mellitus EMT epithelial-mesenchymal transition ECM extracellular matrix FEV1 forced expiratory volume in one second IPF idiopathic pulmonary fibrosis IL interleukin MAPK mitogen-activated protein kinase NOX NADPH oxidase NFκB nuclear factor kappa-light-chain-enhancer of activated B-cells PI3K phosphoinositide-3-kinases RNS reactive nitrogen species ROS reactive oxygen species Rock Rho-associated protein kinase STAT3 signal transducer and activator of transcription 3 STZ streptozotocin Th1 T helper type 1 cell Th2 T helper type 2 cell TGFβ transforming growth factor β T1DM type 1 diabetes mellitus T2DM type 2 diabetes mellitus

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The association between asthma and type 1 diabetes: a paediatric case-cohort study in Finland, years 1981–2009

Abstract: The findings of the present study imply that the association between the diseases is more complex than previously thought, and its direction depends on the sequential appearance of the diseases.

Cited by 30 publications

References 17 publications

The Coincidence of Diabetes Mellitus and Asthma, Their Probable Causal Relationships and Therapeutic Opportunities

The Coincidence of Diabetes Mellitus and Asthma, Their Probable Causal Relationships and Therapeutic Opportunities

Familial Coaggregation of Asthma and Type 1 Diabetes in Children

Diabetic lung disease: fact or fiction?

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