The Association between Asthma and OSA in Children

Garza, Nicholas; Witmans, Manisha; Salud, Martina; Lagera, Pamela Gail D.; Co, Vince Aaron; Tablizo, Mary Anne

doi:10.3390/children9101430

Cited by 10 publications

(10 citation statements)

References 60 publications

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“…OSA is the most common form of SDB in children, particularly those with severe asthma. There is a well-established association between childhood asthma and OSA [57]. Several studies have highlighted a bidirectional relationship between the two conditions.…”

Section: Obesity Asthma and Osasmentioning

confidence: 99%

Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing In Children

Voltan,

Concer,

Pecoraro

et al. 2024

Preprint

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Furthermore, the nasal congestion typical of rhinitis can contribute to upper airway obstruction and sleep-disordered breathing. A vicious circle is created between asthma and sleep-disordered breathing: uncontrolled asthma and sleep-disordered breathing can worsen each other. In children with genetic obesity, despite alterations in the immune system, fewer allergies are found compared to the general population. The causes of this reduced allergenicity are unclear but probably involve genetic, immunological, and environmental factors. Further studies are needed to understand the mechanisms. The study emphasizes the importance of jointly evaluating and managing allergies, obesity, and sleep-disordered breathing in children, considering their close interconnection.

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Section: Obesity Asthma and Osasmentioning

confidence: 99%

Exploring the Complex Interplay of Obesity, Allergic Diseases, and Sleep-Disordered Breathing In Children

Voltan,

Concer,

Pecoraro

et al. 2024

Preprint

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show abstract

“…The association between asthma and OSA has been extensively studied in adults (4) and to a lesser extent in the pediatric population where studies show a possible bidirectional relationship with an overlap in symptoms, the interaction of different risk factors, associated morbidities, and management (6). The study by Dr. Zhang et al in the pediatric population described an association between airway resistance assessed by impulse oscillometry and the severity of OSA (7).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Pulmonary Function Tests and the Apnea-Hypopnea Index in Asthmatic Children

Severiche-Bueno,

Escamilla,

Benavides

et al. 2023

Preprint

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Introduction: OSA in children is an under-recognized and under-diagnosed disease and is an independent risk factor for poor asthma control and an increased number of exacerbations. The association of asthma and OSA is well documented in adults and to a lesser extent in the pediatric population. The association of AHI and lung function in children in a high-altitude city is not described in the literature. Methods: This cross-sectional observational study involved children with asthma (n=64) between 3 and 12 years of age referred to our center in Bogotá (2640m) for polysomnogram between 2012 and 2017. Clinical history, spirometry, oscillometry, and polysomnogram were carried out. OSA was defined from the polysomnographic point of view, as the presence of an obstructive Apnea hypopnea index ≥ 1/hour Results: A total of 64 children with asthma were included. 59.34% were boys and the median age was 7 years. 59.4% of the participants had moderate or severe asthma and 59.4% had uncontrolled asthma. A significant correlation was found between BMI and OAHI. Concerning pulmonary function, a significant negative correlation was found between pre-bronchodilator FEV1 and OAHI as well as a significant correlation between FEV1/FVC and CAHI. For oscillometry, R5 showed a significant negative correlation with AHI. Conclusions: We found in children with asthma living in a high-altitude city a significant and negative correlation between FEV and R5 with AHI as well as a significant and negative correlation between FEV /FVC ratio and CAHI. These findings suggest a correlation between distal airway diameter and sleep apnea severity.

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“…Dr. Ron Harper and colleagues discuss the implications of intermittent hypoxia on insulin secretion in rodents and its implications for pediatric OSA [ 3 ]. Clinically, the association of OSA with asthma and hepatic steatosis in children and adolescents is reported here [ 4 , 5 ]. OSA in high-risk populations such as Down syndrome, neonates, and children with attention deficit hyperactivity disorder are also addressed in this special edition [ 6 , 7 , 8 , 9 ].…”

mentioning

confidence: 99%