The association between apolipoprotein A‐1 plasma level and premature coronary artery disease: A systematic review and meta‐analysis

Aghajani, Mohammad Haji; Neishaboori, Arian Madani; Ahmadzadeh, Koohyar; Toloui, Amirmohammad; Yousefifard, Mahmoud

doi:10.1111/ijcp.14578

Cited by 5 publications

(3 citation statements)

References 49 publications

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“…Haji Aghajani M et al, in a review of seventeen case-control studies, found an association between Apo A 1 levels and premature coronary artery disease. However, the authors note the lack of good quality prospective cohort studies [ 40 ]. Erqou S et al, in a systematic review of thirty-six studies, found that people with smaller Apo A isoforms have an approximately 2-fold higher risk of coronary heart disease or ischemic stroke than those with larger proteins [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of apolipoproteins in COVID-19 patients: A systematic review and meta-analysis

Ulloque-Badaracco

Hernández-Bustamante

Herrera‐Añazco

et al. 2021

Travel Medicine and Infectious Disease

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Section: Discussionmentioning

confidence: 99%

Prognostic value of apolipoproteins in COVID-19 patients: A systematic review and meta-analysis

Ulloque-Badaracco

Hernández-Bustamante

Herrera‐Añazco

et al. 2021

Travel Medicine and Infectious Disease

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“…Our sample size was relatively small, and a larger population would be needed to confirm the association of HDL anti-inflammatory function with NAFLD. Our study included only male participants, because previous studies showed gender differences in lipid profile and HDL subfractions of different study populations [ 26 , 27 ]. Although we removed the confounding effect of gender, the results cannot be generalized to the whole population.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease

et al. 2022

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Background Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular events. HDL exerts various protective functions on the cardiovascular system including anti-inflammatory activity by suppressing adhesion molecules expression in inflammation-induced endothelial cells. This study was designed to search if the anti-inflammatory capacity of apolipoprotein B-depleted plasma (apoB-depleted plasma) is altered in NAFLD patients. Methods A total of 83 subjects including 42 NAFLD and 41 control subjects were included in this cross-sectional study. Anti-inflammatory function of HDL was determined as the ability of apoB-depleted plasma to inhibit tumor necrosis factor-α (TNF-α)-induced expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs). Results Incubation of inflammation-stimulated HUVECs with the NAFLD patients’ apo-B depleted plasma led to higher levels of expression of adhesion molecules compared to the control subjects’ plasma samples, reflecting an impaired anti-inflammatory capacity of apoB-depleted plasma in the NAFLD patients. Impaired anti-inflammatory capacity of apoB-depleted plasma was correlated with fatty liver and obesity indices. After adjustment with obesity indices, the association of anti-inflammatory capacity of apoB-depleted plasma with NAFLD remained significant. Conclusion Impaired anti-inflammatory activity of apoB-depleted plasma was independently associated with NAFLD.

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“…A lipoprotein that has shown a protective effect on inflammation, oxidation, angiogenesis and glucose homeostasis. For this reason, low HDL-C levels have been reported to increase CVR [30] Lipoprotein (a) (Lp-(a)) A protein that carries cholesterol in blood and has demonstrated to be an independent and CVR factor for the advancement of CVD [31] Apolipoprotein B (Apo B) A structural protein that transports very low-density lipoprotein (VLDL-C) and shown as a marker of atherogenic potential and CVR [32] Apolipoprotein A-I (Apo A-I) A primary component of HDL-C which has been shown to have an association with premature CVD [33] Paraoxonase-1 (PON1) A high-density lipoprotein-associated esterase that has been reported to have a direct and an indirect relationship with CVDs [34] Metabolic biomarkers…”

Section: Total Cholesterol (Tc)mentioning

confidence: 99%

Genetic Polymorphisms and Their Interactions with the Risk Factors of Cardiovascular Diseases: Review Chapter

Chalwe¹,

Grobler²,

Oldewage‐Theron³

2022

Risk Factors for Cardiovascular Disease

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Cardiovascular diseases (CVDs) have been reported to have a complex pathogenesis by a number of studies. Atherosclerosis and inflammation have been established as the main contributors to CVDs. Furthermore, genetic polymorphisms have been identified and found to have a correlation with an individual’s susceptibility to developing CVD. Some of these polymorphisms and corresponding cardiovascular risk (CVR) factors include: C174G (Interleukin (IL)-6 association), methylenetetrahydrofolate reductase (MTHFR) C667T/A1298C (hyperhomocysteinaemia), VII R353Q (coagulation factor VII association) and rs247616/rs1968905/rs1270922 (cholesteryl ester transfer protein (CEPT) - cholesterol metabolism) amongst others. At a time when disease prediction, diagnosis and prognosis are still being investigated, these polymorphisms have the potential for use in these areas as well as opening more opportunities in the understanding of CVD. The objective of this chapter was to review the current knowledge about the relationship between genetic polymorphisms and cardiovascular disease.

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The association between apolipoprotein A‐1 plasma level and premature coronary artery disease: A systematic review and meta‐analysis

Cited by 5 publications

References 49 publications

Prognostic value of apolipoproteins in COVID-19 patients: A systematic review and meta-analysis

Prognostic value of apolipoproteins in COVID-19 patients: A systematic review and meta-analysis

Anti-inflammatory function of apolipoprotein B-depleted plasma is impaired in non-alcoholic fatty liver disease

Genetic Polymorphisms and Their Interactions with the Risk Factors of Cardiovascular Diseases: Review Chapter

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