The Association between Anti-Nuclear Antibodies and Obesity is Likely Mediated by Abdominal Adiposity and Systemic Inflammation

Blanco, Irene; Labitigan, Monalyn; Abramowitz, Matthew K.

doi:10.4172/2155-9899.1000513

Cited by 3 publications

(2 citation statements)

References 39 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under these circumstances, the presence of antinuclear antibodies (ANA) imposes a great challenge as ANA may suggest associated autoimmune liver diseases, however the exam lacks specificity, since even the inflammatory state of metabolic syndrome may favor the occurrence of such antibodies (Blanco, 2017).…”

Section: Discussionmentioning

confidence: 99%

Portal hypertension after prolonged use of trastuzumab emtansine: nodular regenerative hyperplasia with autoimmune features

Monteiro

Mussi

Nardelli

et al. 2021

RSD

View full text Add to dashboard Cite

We report a rare complication associated with prolonged use of trastuzumab emtansine (T-DM1) – a composed therapy for HER2+ breast cancer – presenting with laboratorial autoimmune features that could have delayed the diagnosis or led to misdiagnosis. A 55-year-old female was referred to the hepatologist with a computed tomography suggestive of portal hypertension for etiological investigation. History of invasive ductal carcinoma in the right breast undergoing treatment for 5 years. She had already undergone neoadjuvant chemotherapy, mastectomy, radiotherapy and adjuvant chemotherapy. By the time of metastatic diagnosis, she was in monotherapy with T-DM1 for 2.5 years. Upper endoscopy showed esophageal varices and portal hypertension gastropathy. Laboratorial tests revealed increased transaminases, hypergammaglobulinemia and positive antinuclear antibody. Liver biopsy was performed for autoimmune hepatitis differential diagnosis but revealed nodular regenerative hyperplasia. T-DM1 was discontinued. After a 2-year follow-up, the patient did not present any complications of portal hypertension, although persisted with esophageal varices.

show abstract

Section: Discussionmentioning

confidence: 99%

Portal hypertension after prolonged use of trastuzumab emtansine: nodular regenerative hyperplasia with autoimmune features

Monteiro

Mussi

Nardelli

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

“…Some studies found no association between recurrent miscarriage and a positive ANA (80)(81)(82), and others note that the likelihood of miscarriage is not increased with women with a positive ANA (83)(84)(85). Moreover, a tendency to miscarry is associated with factors such as advanced maternal age and obesity (86,87), both of which are known to be associated with a higher prevalence of ANA positivity (88,89). Also, autoimmune thyroid disorders are associated with recurrent miscarriage (69).…”

Section: Treating Rheumatologic Aspects Of Recurrent Pregnancy Lossmentioning

confidence: 99%

Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence?

Odendaal

Quenby

Sammaritano

et al. 2019

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

Clinical, Laboratory, and Histologic Correlates of Serum Antinuclear Antibody in Hispanic Pediatric Patients With Nonalcoholic Fatty Liver Disease

Zhu

Kinnear

et al. 2022

American Journal of Clinical Pathology

View full text Add to dashboard Cite

Objectives The significance of antinuclear antibody (ANA) positivity in pediatric Hispanic patients with nonalcoholic fatty liver disease (NAFLD) is unknown. Methods ANA status was correlated with clinical, laboratory, and histologic parameters in Hispanic patients with a histologic diagnosis of NAFLD. Results Thirty-eight Hispanic children (27 male and 11 female) underwent liver biopsy at a median age of 12.1 years. Twenty patients (53%) had positive ANAs. The ANA-positive patients had higher fasting insulin levels (median [interquartile range (IQR)], 32.4 [25.4] µU/mL) and higher insulin resistance (median [Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) IQR], 5.9 [3.1]) than the ANA-negative patients (fasting insulin: median [IQR], 17 [13.9] µU/mL and median [HOMA-IR IQR], 3.5 [2.6] µU/mL; P = .05 and .01, respectively). Serum high-density lipoprotein (HDL) cholesterol levels were higher in the ANA-negative patients (median [IQR], 47 [18] mg/dL) than the ANA-positive patients (38 [12] mg/dL) (P = .03). There were no statistical differences in a series of demographic, clinical, laboratory, and histologic parameters between the ANA-positive and the ANA-negative patients. At a median follow-up of 2.6 years, alanine aminotransferase was significantly lower than the baseline levels in both groups. In 1 patient undergoing ANA retesting, the titer had normalized from a baseline of 1:1,280 3.8 years earlier. Conclusions In pediatric Hispanic patients with NAFLD, a positive ANA result is associated with insulin resistance and lower HDL cholesterol levels.

show abstract

The Association between Anti-Nuclear Antibodies and Obesity is Likely Mediated by Abdominal Adiposity and Systemic Inflammation

Cited by 3 publications

References 39 publications

Portal hypertension after prolonged use of trastuzumab emtansine: nodular regenerative hyperplasia with autoimmune features

Portal hypertension after prolonged use of trastuzumab emtansine: nodular regenerative hyperplasia with autoimmune features

Immunologic and rheumatologic causes and treatment of recurrent pregnancy loss: what is the evidence?

Clinical, Laboratory, and Histologic Correlates of Serum Antinuclear Antibody in Hispanic Pediatric Patients With Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About