The Association between Angiotensin II Type 1 Receptor Gene A1166C Polymorphism and Non-alcoholic Fatty Liver Disease and Its Severity

Abstract

BACKGROUND Genetic predisposition may have important role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Angiotensin II type I receptor (AGTR1) has been known to involve in the process of liver steatosis and fibrosis. This study aimed to investigate the association between AGTR1 A1166C polymorphism and NAFLD. METHODS A cross-sectional study was conducted during May 2014-May 2015 among healthy adults referring to our radiology clinic for abdominal sonography. AGTR1 A1166C polymorphism was evaluated in subjects with NAFLD and healthy individuals using allelic discrimination method. RESULTS 58 subjects with NAFLD were compared with 88 healthy individuals without NAFLD. The frequency of AA and CC genotypes of AGTR1 was significantly higher in patients with NAFLD compared with controls (p = 0.029 and 0.042, respectively). C allele was more detected in subjects with NAFLD compared with the healthy controls (OR: 2.1; 95% CI: 1.23-3.61, p = 0.006). CC genotype (OR: 10.62; 95% CI: 1.05-106.57, p = 0.045) and C allele (OR: 6.81; 95% CI: 1.42- 32.48, p = 0.016) were also predictors of severe fatty liver disease in our study population. CONCLUSION Our results provide the first evidence that AGTR1 gene A1166C polymorphism not only is associated with NAFLD and but also may predict its severity

Update on Non-Alcoholic Fatty Liver Disease-Associated Single Nucleotide Polymorphisms and Their Involvement in Liver Steatosis, Inflammation, and Fibrosis: A Narrative Review

“…The AGTR1 rs5186 C allele can predict the risk and severity of NAFLD in Caucasian and Iranian populations [ 68 , 107 ] . The polymorphism promotes fat-induced proinflammatory response and enhances NF-κB activation in mononuclear cells.…”

Increasing Neutrophil Elastase and Decreasing Its Inhibitor, Alpha 1-Antitrypsin, in Patients with Non-Alcoholic Fatty Liver Disease

“…Our results highlighted the importance of neutrophils and their released elastase in the pathogenesis of NAFLD. Being one of the most common causes of chronic liver damage, NAFLD is characterized by hepatocyte ballooning, as well as cytoskeletal and apoptotic changes in hepatocytes that may also increase the risk of cardiovascular disease (CVD) (15)(16)(17)(18)(19)(20). The accumulation of neutrophils in the liver with elevated levels of immunoreactive neutrophil elastase explains inflammation in steatohepatitis.…”

A panel design of gene polymorphism detection of metabolic dysfunction-associated fatty liver disease in East Asian population

“…The AGTR1 gene,known as angiotensin II receptor 1 gene,is an important gene that involves the Published by Francis Academic Press, UK -39-activation in the renin-angiotensin system as well as metabolic diseases [12]. AGTR1 blocker was shown to have a preventive role of in the progression of NASH in both animal and human studies.…”