The association between ambient temperature and the risk of preterm birth in China

Guo, Tongjun; Wang, Yuanyuan; Zhang, Honggang; Ya, Zhang; Zhao, Jun; Wang, Yan; Xie, Xiaoxu; Wang, Long; Zhang, Qian; Liu, Dujia; He, Yuan; Yang, Ying; Xu, Jing; Peng, Zuoqi; Ma, Xu

doi:10.1016/j.scitotenv.2017.09.104

Cited by 66 publications

(54 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past few decades, an increasing number of epidemiological studies have evaluated the influence of temperature exposure during pregnancy on PTB (Barreca and Schaller 2019;Carolan-Olah and Frankowska 2014;Guo et al 2018;Zhang et al 2017) and other adverse birth outcomes such as birth defects (Soim et al 2017). Most studies suggested an association between high-temperature exposure during the week prior to the delivery and PTB (Basu et al 2010;Ha et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Independent and Combined Effects of Heatwaves and PM2.5 on Preterm Birth in Guangzhou, China: A Survival Analysis

Wang

Benmarhnia

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

BACKGROUND: Both extreme heat and air pollution exposure during pregnancy have been associated with preterm birth; however, their combined effects are unclear. OBJECTIVES: Our goal was to estimate the independent and joint effects of heatwaves and fine particulate matter [PM <2:5 lm in aerodynamic diameter (PM 2:5 )], exposure during the final gestational week on preterm birth. METHODS: Using birth registry data from Guangzhou, China, we included 215,059 singleton live births in the warm season (1 May-31 October) between January 2015 and July 2017. Daily meteorological variables from 5 monitoring stations and PM 2:5 concentrations from 11 sites were used to estimate district-specific exposures. A series of cut off temperature thresholds and durations (2, 3, and 4 consecutive d) were used to define 15 different heatwaves. Cox proportional hazard models were used to estimate the effects of heatwaves and PM 2:5 exposures during the final week on preterm birth, and departures from additive joint effects were assessed using the relative excess risk due to interaction (RERI). RESULTS: Numbers of preterm births increased in association with heatwave exposures during the final gestational week. Depending on the heatwave definition used, hazard ratios (HRs) ranged from 1.10 (95% CI: 1.01, 1.20) to 1.92 (1.39, 2.64). Associations were stronger for more intense heatwaves. Combined effects of PM 2:5 exposures and heatwaves appeared to be synergistic (RERIs >0) for less extreme heatwaves (i.e., shorter or with relatively low temperature thresholds) but were less than additive (RERIs <0) for more intense heatwaves. CONCLUSIONS: Our research strengthens the evidence that exposure to heatwaves during the final gestational week can independently trigger preterm birth. Moderate heatwaves may also act synergistically with PM 2:5 exposure to increase risk of preterm birth, which adds new evidence to the current understanding of combined effects of air pollution and meteorological variables on adverse birth outcomes. https://doi.

show abstract

Section: Discussionmentioning

confidence: 99%

Independent and Combined Effects of Heatwaves and PM2.5 on Preterm Birth in Guangzhou, China: A Survival Analysis

Wang

Benmarhnia

et al. 2020

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…The strong association between short-term temperature exposure and PTB in Detroit, Michigan, USA was consistent with several other studies’ observed associations between PTB or diminished gestational age and temperature exposures within the week prior to delivery at regionally high temperatures. Regions in which these associations have been found include Central Australia (8.3% at 40°C daily maximum temperature),11 Northern California, USA (11.6% increase for a 5.6°C increase in weekly average AT in the warm season),34 Alabama, USA (32.4% increase with two consecutive days of daily mean temperatures above the 98 th percentile),39 Barcelona, Spain (5-day reduction in average gestational age with heat index above the 99 th percentile),8 Rome, Italy (1.9% increase per 1°C increase in maximum AT in the prior 2 days and 19% increase during heat waves),40 Brisbane, Australia (13% to 100% increase during heat waves), in an aggregated sample of 12 US cities (12% to 16% increase with 2.8°C increase in prior week),12 in Southern China (7% increase with previous-week temperatures above 95 th percentile)10 and in a multi-city USA sample (2% increased PTB risk with extreme heat in the prior 4 days) 41…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, regions where associations between temperature and PTB were null in rigorously conducted daily time series studies included Brandenburg and Saxony, Germany,20 and London, UK,19 which are in ‘temperate oceanic climates,’ where all months have average temperatures below 22°C 45. Additionally, Guo et al 10 found an association between previous-week temperature and PTB only in the ‘hot’ region of China, defined as having annual average temperatures 19°C or higher. Furthermore, in a survival analysis of previous-week temperature and PTB in 18 European cities, the pooled effect estimates were null, and no individual city results were presented 46.…”

Section: Discussionmentioning

confidence: 99%

“…Studies in cities in Australia, Quebec, China, Belgium, Italy, Spain and across the USA have all found significant positive associations between hot temperatures within the week preceding delivery and PTB. 5 6 8–16 High ambient temperatures in the month of conception and the third trimester were also positively associated with PTB in Changsha, China 17 18. However, earlier, rigorously conducted time series analyses of temperature and PTB in Germany and in London, England, did not find associations 19 20.…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Time series analysis of total and direct associations between high temperatures and preterm births in Detroit, Michigan

et al. 2020

View full text Add to dashboard Cite

ObjectivesPreterm births (PTBs) represent significant health risks, and several studies have found associations between high outdoor temperatures and PTB. We estimated both the total and natural direct effects (independent of particulate matter, ozone and nitrogen dioxide air pollutants) of the prior 2-day mean apparent temperature (AT) on PTB. We evaluated effect modification by maternal age, race, education, smoking status and prenatal care.Design and settingWe obtained birth records and meteorological data for the Detroit, Michigan, USA area, for the warm months (May to September), 1991 to 2001. We used a time series Poisson regression with splines of AT, wind speed, solar radiation and citywide average precipitation to estimate total effects. To accommodate multiple mediators and exposure-mediator interactions, AT inverse odds weights, predicted by meteorological and air pollutant covariates, were added in a subsequent model to estimate direct effects.ResultsAt 24.9°C relative to 18.6°C, 10.6% (95% CI: 3.8% to 17.2%) of PTBs were attributable to the total effects of AT, and 10.4% (95% CI: 2.2% to 17.5%) to direct effects. Relative excess risks of interaction indicated that the risk of PTB with increasing temperature above 18.6°C was significantly lower among black mothers and higher among mothers less than 19, older than 30, with late or no prenatal care and who smoked.ConclusionThis additional evidence of a direct association between high temperature and PTB may motivate public health interventions to reduce extreme heat exposures among pregnant women, particularly among those who may have enhanced vulnerability.

show abstract

“…However, the rate of preterm births varies from 5 to 6% in several European nations to ≥15% in some parts of Africa [4]. In 2013, Guo et al [5] investigated the birth outcomes of pregnant women from 132 cities in China and found that 7.2% of live births were preterm. The incidence of preterm birth is continuously increasing in many countries [6].…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cell-derived secretomes for therapeutic potential of premature infant diseases

et al. 2020

View full text Add to dashboard Cite

Preterm birth is a complex syndrome and remains a substantial public health problem globally. Its common complications include periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC) and retinopathy of prematurity (ROP). Despite great advances in the comprehension of the pathogenesis and improvements in neonatal intensive care and associated medicine, preterm birth-related diseases remain essentially without adequate treatment and can lead to high morbidity and mortality. The therapeutic potential of mesenchymal stem/stromal cells (MSCs) appears promising as evidenced by their efficacy in preclinical models of pathologies relevant to premature infant complications. MSC-based therapeutic efficacy is closely associated with MSC secretomes and a subsequent paracrine action response to tissue injuries, which are complex and abundant in response to the local microenvironment. In the current review, we summarize the paracrine mechanisms of MSC secretomes underlying diverse preterm birth-related diseases, including PVL, BPD, NEC and ROP, are summarized, and focus is placed on MSC-conditioned media (CM) and MSC-derived extracellular vesicles (EVs) as key mediators of modulatory action, thereby providing new insights for future therapies in newborn medicine.lung function and help to remove the ventilator as soon as possible [12]. However, many studies have reported that glucocorticoid can increase the risk of adverse reactions, such as those by the nervous system, in the early or late stages, and its dose and course of treatment are not certain [13,14]. In terms of surgical treatment, preterm infants with surgical NEC are at risk of significant growth reduction and neurodevelopmental impairment (NDI), including cerebral palsy, deafness and blindness [15,16]. These sequelae and complications of prematurity-related diseases affect not only the neonatal period, but also infancy and childhood, and even adolescence and adulthood [17][18][19]. Currently, although various treatment methods have been found to achieve certain curative effects, there still exist several side effects and disputes above. Thus, it is necessary to explore and develop new therapies for the treatment and prevention of premature infant diseases.Accumulating studies have established the importance and feasibility of stem cell-based therapies to ameliorate many degenerative and inflammatory diseases. Among these stem/progenitor cell types, mesenchymal stem/stromal cells (MSCs) have received more extensive attention because they are easily extracted, exert anti-inflammatory effects, have low immunogenicity and can renew themselves. The therapeutic potential of MSCs has been demonstrated in many diseases such as cancer [20,21] and cardiovascular [22,23] and lung [24][25][26] diseases. MSCs also represent a promising and growing approach to the targeting of various pathological processes and cellular impairments underlying the major abnormalities in premature infant and preterm-associated neonatal diseases [27][28]...

show abstract

The association between ambient temperature and the risk of preterm birth in China

Cited by 66 publications

References 20 publications

Independent and Combined Effects of Heatwaves and PM2.5 on Preterm Birth in Guangzhou, China: A Survival Analysis

Independent and Combined Effects of Heatwaves and PM2.5 on Preterm Birth in Guangzhou, China: A Survival Analysis

Time series analysis of total and direct associations between high temperatures and preterm births in Detroit, Michigan

Mesenchymal stem cell-derived secretomes for therapeutic potential of premature infant diseases

Contact Info

Product

Resources

About