The association between ambient air pollution and blood lipids: A longitudinal study in Shijiazhuang, China

Zhang, Kaihua; Wang, Haoyuan; He, Weiliang; Chen, Gongbo; Lu, Peng; Xu, Rongbin; Pei, Yu; Ye, Tingting; Guo, Sun Wei; Li, Shanshan; Xie, Yinyu; Hao, Zhihua; Wang, Hebo; Guo, Yuming

doi:10.1016/j.scitotenv.2020.141648

Cited by 47 publications

(30 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies pointed to the potential role of ambient air pollution or traffic-related air pollution in specific adult populations. It was proposed that older adults will be more sensitive to obesogenic and adipogenic effects of PM [353][354][355]. Sex, age, or a genetic susceptibility to higher BMI may sensitize individuals during long-term exposure to ambient air pollutants, increasing the risk of obesity.…”

Section: Human Studiesmentioning

confidence: 99%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

102

View full text Add to dashboard Cite

Section: Human Studiesmentioning

confidence: 99%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

102

View full text Add to dashboard Cite

“…Therefore, we believe that compared with gaseous pollutants, ambient particulate matter exposure is more strongly associated with increased TC, Lp(a) and decreased HDL-C, and the harmful effect of PM 10 is greater than that of PM 2.5 . A longitudinal study in Shijiazhuang, China also suggests that ambient particulate matter may have a greater impact on lipid health than gaseous pollutants ( 49 ). In a hypertensive population with arteriosclerosis, the positive associations between ambient particulate matter exposure and HDL-C and LDL-C were partially reversed after adjustment for gaseous pollutants.…”

Section: Discussionmentioning

confidence: 99%

Effects of ambient particulate exposure on blood lipid levels in hypertension inpatients

Gao

Li²,

Huang³

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundWith modernization development, multiple studies of atmospheric particulate matter exposure conducted in China have confirmed adverse cardiovascular health effects. However, there are few studies on the effect of particulate matter on blood lipid levels in patients with cardiovascular disease, especially in southern China. The purpose of this study was to investigate the association between short- and long-term exposure to ambient particulate matter and the levels of blood lipid markers in hypertension inpatients in Ganzhou, China.MethodsData on admission lipid index testing for hypertension inpatients which were divided into those with and without arteriosclerosis disease were extracted from the hospital's big data center from January 1, 2016 to December 31, 2020, and air pollution and meteorology data were acquired from the China urban air quality real time release platform from January 1, 2015 to December 31, 2020 and climatic data center from January 1, 2016 to December 31, 2020, with data integrated according to patient admission dates. A semi-parametric generalized additive model (GAM) was established to calculate the association between ambient particulate matter and blood lipid markers in hypertension inpatients with different exposure time in 1 year.ResultsLong-term exposure to particulate matter was associated with increased Lp(a) in three kinds of people, and with increased TC and decreased HDL-C in total hypertension and hypertension with arteriosclerosis. But particulate matter was associated with increased HDL-C for hypertension inpatients without arteriosclerosis, at the time of exposure in the present study. It is speculated that hypertension inpatients without arteriosclerosis has better statement than hypertension inpatients with arteriosclerosis on human lipid metabolism.ConclusionLong-term exposure to ambient particulate matter is associated with adverse lipid profile changes in hypertension inpatients, especially those with arteriosclerosis. Ambient particulate matter may increase the risk of arteriosclerotic events in hypertensive patients.

show abstract

“…medium-(months), and long-term (years) exposure to particulate air pollution with dysregulated aopB-containing lipoprotein metabolism, that is, increased levels of apoB, 5 VLDL, 6 LDL-C (LDL-cholesterol, a major proportion of apoB-containing lipoproteins), [7][8][9] and non-HDL-C (nonhigh-density lipoprotein cholesterol, a clinical surrogate of the apoB level). 10 However, the mechanism underlying PM 2.5 -induced proatherogenic effects is not completely understood.…”

mentioning

confidence: 99%

Ambient Air Pollution and Atherosclerosis: A Potential Mediating Role of Sphingolipids

Wang

Gong

et al. 2022

ATVB

View full text Add to dashboard Cite

Background: The pathophysiological mechanisms of air pollution-induced atherosclerosis are incompletely understood. Sphingolipids serve as biological intermediates during atherosclerosis development by facilitating production of proatherogenic apoB (apolipoprotein B)-containing lipoproteins. We explored whether sphingolipids mediate the proatherogenic effects of air pollution. Methods: This was a prospective panel study of 110 participants (mean age 56.5 years) followed from 2013 to 2015 in Beijing, China. Targeted lipidomic analyses were used to quantify 24 sphingolipids in 579 plasma samples. The mass concentrations of ambient particulate matter ≤2.5 μm in diameter (PM 2.5 ) were continuously monitored by a fixed station. We evaluated the associations between sphingolipid levels and average PM 2.5 concentrations 1–30 days before clinic visits using linear mixed-effects models and explored whether sphingolipids mediate PM 2.5 -associated changes in the levels of proatherogenic apoB-containing lipoproteins (LDL-C [low-density lipoprotein cholesterol] and non-HDL-C [nonhigh-density lipoprotein cholesterol]) using mediation analyses. Results: We observed significant increases in the levels of non-HDL-C and fourteen sphingolipids associated with PM 2.5 exposure, from short- (14 days) to medium-term (30 days) exposure time windows. The associations exhibited near-monotonic increases and peaked in 30-day time window. Increased levels of the sphingolipids, namely, sphinganine, ceramide C24:0, sphingomyelin C16:0/C18:0/C18:1/C20:0/C22:0/C24:0, and hexosylceramide C16:0/C18:0/C20:0/C22:0/C24:0/C24:1 significantly mediated 32%, 58%, 35% to 93%, and 23% to 86%, respectively, of the positive association between 14-day PM 2.5 average and the non-HDL-C level, but not the LDL-C level. Similar mediation effects (19%–91%) of the sphingolipids were also observed in 30-day time window. Conclusions: Our results suggest that sphingolipids may mediate the proatherogenic effects of short- and medium-term PM 2.5 exposure.

show abstract

The association between ambient air pollution and blood lipids: A longitudinal study in Shijiazhuang, China

Cited by 47 publications

References 48 publications

Obesity II: Establishing causal links between chemical exposures and obesity

Obesity II: Establishing causal links between chemical exposures and obesity

Effects of ambient particulate exposure on blood lipid levels in hypertension inpatients

Ambient Air Pollution and Atherosclerosis: A Potential Mediating Role of Sphingolipids

Contact Info

Product

Resources

About