The Association Between Alcohol Consumption and Biomarkers of Alcohol Exposure With Total Serum Immunoglobulin E Levels

Abstract

In conclusion, biomarkers of alcohol exposure were positively associated with total serum IgE levels supporting that the positive association between self-reported alcohol intake and IgE levels observed in previous studies is real and not due to misclassification of alcohol intake or confounding by other factors that may be linked to both alcohol intake and total serum IgE levels.

Alcohol hyper‐responsiveness in chronic rhinosinusitis with nasal polyps

“…First alcohol may influence immunology, or conversely the altered immunology in chronic airway diseases may cause the respiratory reactions upon exposure to alcohol. Several studies propose alcohol could cause eosinophilic inflammation or induce IgE supporting the first possibility . The latter hypothesis is analogous to reports in NERD, suggesting respiratory mucosal inflammatory disease could be the underlying mechanism in aspirin hypersensitivity .…”

Can childhood asthma be predicted at birth?

“…Maternal alcohol use during pregnancy was only reported as a dichotomous variable, but was associated with a reduced risk of all asthma‐related outcomes. To our knowledge, in utero exposure to alcohol has been associated with an increased IgE [34] and childhood atopic eczema [35] but not with childhood asthma [36]. The explanation for our finding is unclear.…”

Raised levels of immunoglobulin G, A and M are associated with an increased risk of total and cause-specific mortality: the Vietnam Experience Study

“…However, high levels of Ig are also associated with disease and/or poor health behaviours. For example, high IgE levels are associated with the atopic diseases asthma and eczema and high levels of IgE are positively associated with alcohol consumption among individuals with atopic asthma7; higher IgA production in the bowel may also be part of the cause of inflammatory bowel disease 8. Certain types of kidney disease are associated with infiltration of specific IgG4-positive plasma cells9 and abnormalities of the IgA system 10.…”