The association between adherence to the Mediterranean diet and adiponectin levels among healthy adults: the ATTICA study

Fragopoulou, Elizabeth; Panagiotakos, Demosthenes B.; Pitsavos, Christos; Tampourlou, Metaxia; Chrysοhoou, Christina; Nomikos, Tzortzis; Antonopoulou, Smaragdi; Stefanadis, Christodoulos

doi:10.1016/j.jnutbio.2008.12.013

Cited by 68 publications

(56 citation statements)

References 41 publications

(63 reference statements)

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“…This result contradicts those from previous studies on this issue. In fact, cross-sectional studies have suggested that individuals with a higher adherence to the MedDiet, as determined by a MedDiet score, have higher concentrations of adiponectin than individuals with lower scores in both healthy and diabetic individuals, even after adjustments for potential confounding variables such as age, body composition and traditional risk factors 29,30 . Besides our study, no fully controlled interventional study has investigated this issue yet.…”

Section: Discussionmentioning

confidence: 99%

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

et al. 2014

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A bstract Background/O bjective: Most of the interventional studies have investigated the impact of the diet on adiponectin and leptin concentrations only in men or in women. Consequently, it is still unknown whether the consumption of a healthy diet influences in a sex-specific manner these adipocytokines.We examined sex differences in the effects of the Mediterranean diet (MedDiet) on adiponectin and leptin concentrations and determined whether changes in these adipocytokines are associated with changes in cardiovascular risk factors in both sexes.Subjects/Methods: Participants were 38 men and 32 premenopausal women (24-53y) with slightly elevated LDL-C concentrations (3.4-4.9 mmol/l) or total cholesterol/HDL-C and cardiovascular risk factors were measured before and after a 4-week fully-controlled isoenergetic MedDiet.Results: Adiponectin concentration decreased in response to the MedDiet, but this decrease reached statistical significance only in men (P<0.001 for men and P=0.260 for women; sex-by-time interaction, P=0.072). Adjustments for body weight or waist circumference did not change results obtained.Changes in adiponectin were positively associated with concomitant variations in HDL-C in men (r=0.52, P=0.003) and with variations in apo A-1 and insulin sensitivity as calculated by both HOMA-IS and Cederholm indices in women (respectively r=0.44, P=0.021; r=0.79, P<0.001 and r=0.47, P=0.020). The MedDiet had no impact on leptin and leptin-to-adiponectin ratio in both sexes.Conclusions: Results suggest sex difference in adiponectin response to the short-term consumption of the MedDiet, with only men experiencing a decrease. Also sex-specific patterns of associations between changes in adiponectin concentration and changes in cardiovascular risk factors were observed.

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Section: Discussionmentioning

confidence: 99%

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

et al. 2014

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“…Epidemiological studies have shown that people consuming a Mediterranean diet tend to have a lower risk of developing cardiovascular diseases, diabetes, and cancer 13) . At the molecular level, the beneficial effects of consuming Mediterranean diet components are believed to be mediated at least in part by their positive modulation of adiponectin [14][15][16] ; however, it is unclear whether the linear relationship between a Mediterranean diet and adiponectin is sustained under the influence of the adiponectin-lowering effects of cigarette smoking and whether this relationship is independent of potential confounders in subjects adhering long term to a Mediterranean-style diet.…”

Section: Anthropometrics and Clinical Parametersmentioning

confidence: 99%

The Relationship between a Mediterranean Diet and Circulating Adiponectin Levels is Influenced by Cigarette Smoking

Al‐Attas

Hussain

Al-Daghri

et al. 2013

JAT

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Aim: Adherence to a Mediterranean diet has been shown to lower the risk of developing several chronic diseases. The ability to augment circulating adiponectin levels is proposed as an underlying mechanism mediating the beneficial effects of this diet. We aimed to examine whether the positive relationship between the Mediterranean diet and adiponectin is altered by cigarette smoking, taking potential confounders into consideration. Methods: Plasma adiponectin levels were enzymatically measured in 45 never smokers, 61 smokers and 34 ex-smokers who adhered to a Mediterranean style diet and in 41 never smokers who did not adhere to the diet. Results: Plasma adiponectin levels increased significantly in nonsmoking diet adherents compared to nonsmoking non-diet adherents. Among the diet adherents adiponectin decreased significantly in both moderate and heavy smokers compared to never smokers and significantly increased in quitters compared to smokers. Multiple regression analysis, controlling for age, obesity, Mediterranean diet and insulin resistance revealed an independent inverse association of smoking with adiponectin. Adiponectin levels remained significant and similar in subjects stratified according to age (＜/＞50 years), BMI (＜/＞25 kg/m 2 ) and HOMA-IR (＜/＞1.6). Conclusions: Despite its positive effects on adiponectin, the Mediterranean diet failed to negate the adiponectin-lowering effect of cigarette smoking, demonstrating the profound and independent capacity of cigarette smoke to negatively influence human health. J Atheroscler Thromb, 2013; 20:313-320.

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“…Thereafter over a period of 30 years, a number of investigators have reported that the Mediterranean diet is associated with low rates of degenerative diseases such as cardiovascular disease (CVD) (Estruch et al, 2006, Pitsavos et al, 2005, coronary heart disease (CHD) (Fung et al, 2009), stroke (Fung et al, 2009), certain types of cancers (La Vecchia, 2004, Dixon et al, 2007, diabetes (Martinez-Gonzalez et al, 2008), Alzheimer's disease (Scarmeas et al, 2009) and non-alcoholic fatty liver disease (Fraser et al, 2008). Research has also demonstrated that Mediterranean populations have increased life expectancy (Hu, 2003, Visioli et al, 2005, Trichopoulou et al, 2005, reduced risk of developing disorders such as metabolic syndrome (Tortosa et al, 2007, Babio et al, 2008 and have decreased levels of systematic inflammation (Dai et al, 2009, Fragopoulou et al, 2010, Panagiotakos et al, 2009). …”

Section: Olive Oil a Hallmark Of The Mediterranean Dietmentioning

confidence: 99%

Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil

Cicerale¹,

Lucas²,

Keast³

2012

Olive Oil - Constituents, Quality, Health Properties and Bioconversions

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The association between adherence to the Mediterranean diet and adiponectin levels among healthy adults: the ATTICA study

Cited by 68 publications

References 41 publications

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

Effects of the traditional Mediterranean diet on adiponectin and leptin concentrations in men and premenopausal women: do sex differences exist?

The Relationship between a Mediterranean Diet and Circulating Adiponectin Levels is Influenced by Cigarette Smoking

Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil

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