The association between acanthosis nigricans and dysglycemia in an ethnically diverse group of eighth grade students

Rafalson, Lisa; Pham, Trang; Willi, Steven M.; Marcus, Marsha D.; Jessup, Ann; Baranowski, Tom

doi:10.1002/oby.20129

Cited by 17 publications

(18 citation statements)

References 38 publications

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“…[10] AN has been found more often among overweight or obese individuals in ethnic groups that typically experience a higher incidence of type 2 diabetes, including African Americans, Hispanics, American and Canadian Indians, Japanese, Pacific Islanders, Asian and Middle Eastern populations. [11] Data is also suggestive of significant univariate association between AN and BMI. [12] Studies have shown that about 7% of young American males have impaired glucose tolerance (IGT), with higher prevalence of impaired fasting glucose (IFG) in overweight adolescents (17.8%).…”

Section: Discussionmentioning

confidence: 87%

Association of acanthosis nigricans with anthropometric and biochemical parameters in young Indian males

Jorwal¹,

Keshwani²,

Verma³

2014

Ann Nigerian Med

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A canthosis nigricans (AN) is a skin condition characterized by dark, coarse, velvety to grey, thickened skin folds; commonly found at the back of the neck, axilla, elbows, groin, under the breasts, and at the belt line around the umbilicus. In severe cases, acrochordon may also develop on the discolorations. [1] AN is associated with insulin resistance and is highly correlated with hyperinsulinemia, type 2 diabetes and obesity. [2] Western literature report a high rates of association between AN and type 2 diabetes in nonwhite as well as in other ethnic groups. [3] The prevalence of AN in the literature varies from 7% in an unselected population to 74% in obese persons; whereas little information is available on its prevalence in young adult subjects. [4,5] To the best of our knowledge there are very few studies showing the prevalence of AN in relation to various anthropometric measurements in Indians. As adolescent obesity rates increase, the appearance of AN earlier in life has also increased. There are currently only a couple of studies in young Indians regarding this association. The purpose of this investigation was to determine the association between AN and multiple health parameters in young males. SUBJECTS AND METHODSAn analytical cross-sectional design was utilized to assess the relationship between the presence of AN and the dependent variables of body mass index A B S T R A C TBackground: Acanthosis nigricans (AN) is a skin condition associated with insulin resistance, and highly correlated with hyperinsulinemia, type 2 diabetes, and obesity; with scarcity of information regarding its status in young adult subjects. Aim: To determine the association between the presence of AN with biochemical parameters and anthropometric variables. Subjects and Methods:This analytical cross-sectional study included young male subjects from outpatient department of Medicine of a tertiary care center in North India. They were divided into three group of 40 subjects each. Group I consisted of subjects having AN, Group II consisted of obese/overweight subjects without AN, and Group III consisted of control subjects without AN or obesity. Covariates included family history of diabetes. Results: There was a signifi cant positive association (P < 0.001) between AN and high body mass index (BMI), fasting glucose, waist-hip ratio (WHR), and systolic blood pressure (BP) even when controlled for obesity. For lipoproteins, insulin, and diastolic BP, the association even though signifi cant, was inconsistent when obesity was taken into consideration. Conclusion: Individuals with AN have lower high-density lipoproteins, and higher BMI, fasting blood glucose (FBG), serum insulin, total cholesterol, triglycerides, low-density lipoproteins, and systolic as well as diastolic pressure. Irrespective of being obese, AN is associated with a high BMI, WHR, FBG and systolic BP in young adults.

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Section: Discussionmentioning

confidence: 87%

Association of acanthosis nigricans with anthropometric and biochemical parameters in young Indian males

Jorwal¹,

Keshwani²,

Verma³

2014

Ann Nigerian Med

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“…This suggests that AN imposes additional risk for dysglycemia over that from obesity alone. Hence, Rafalson et al concluded that AN is an easily identifiable clinical marker of impaired glucose tolerance and high-risk glycated hemoglobin 32. However, although most studies report that AN is a clinical indicator of underlying IR, some authors believe that AN is not an independent marker of IR 94,95…”

Section: The Impact Of An On Obese Adolescentsmentioning

confidence: 99%

Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges

Ng¹

2016

AHMT

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Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Current understanding suggests that it is associated with insulin resistance and has a unique role in secondary prevention. The purpose of this narrative review is to provide a comprehensive overview of AN in obese adolescents, covering its history, current knowledge on the condition, its clinical significance, management challenges, and the direction of future research.

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“…Lesion is localized on neck, axillary and inguinal areas, especially. It is associated with insulin resistance, obesity, malignancy, and diabetes mellitus [9]. In this case, axillary acanthosis nigricans was Glucose (mg/dL) 518 0 described and hyperinsulinemia with suspect type II diabetes mellitus was identified by laboratory findings.…”

Section: Discussionmentioning

confidence: 74%

An Uncommon Clinical Case with Fanconi Syndrome, Acanthosis Nigricans and Hyperinsulinemia

Karadeniz

2013

J Med Cases

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Fanconi syndrome (FS) is a disease of the proximal renal tubules of the kidney in which glucose, amino acids, uric acid, phosphate, and bicarbonate are passed into the urine, instead of being reabsorbed. Laboratory findings are important for the diagnosis such as hyponatremia, hypopotassemia, hypocalcemia, hypophosphatemia, glucosuria, proteinuria, and metabolic acidosis. In this presentation, the patient admitted to the hospital with polyuria, polydypsia, weakness of the extremity muscles, and axiller brown colored cutaneous lesions. Blood and urine laboratory test results were consistent with FS. Besides, hyperglycemia and hyperinsulinemia were determined as an indicator of diabetes mellitus. Axillary skin lesions were described as acanthosis nigricans. This case was presented to point out the coexistence of renal proximal tubule dysfunction, hyperinsulinemia, and acanthosis nigricans as an unusual clinical feature in the literature.

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The association between acanthosis nigricans and dysglycemia in an ethnically diverse group of eighth grade students

Cited by 17 publications

References 38 publications

Association of acanthosis nigricans with anthropometric and biochemical parameters in young Indian males

Association of acanthosis nigricans with anthropometric and biochemical parameters in young Indian males

Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges

An Uncommon Clinical Case with Fanconi Syndrome, Acanthosis Nigricans and Hyperinsulinemia

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