The association among enterobacterial flora, dietary factors, and prognosis in patients with ulcerative colitis

Abstract

The role of enterobacterial flora in the onset and progression of inflammatory bowel diseases is a topic of considerable interest. Here, we assessed the association among enterobacterial flora, dietary factors, and ulcerative colitis (UC) progression. Forty six patients with UC who were diagnosed as being in remission were enrolled. We collected each patient's stool sample one or two days before diagnostic colonoscopy. After colonoscopy, we observed the patients for one year and then retrospectively divided them into two groups: remission (n = 39) and relapse (n = 7) groups, depending on whether the relapse occurred during the follow up period, and analyzed the relationship among patient characteris tics, dietary factors, enterobacterial flora, and UC relapse. Overall, there were no significant differences in bacterial community pop ulations between the remission and relapse groups, except that the order Lactobacillales was detected at a significantly higher rate in the relapse than in the remission group (100% vs 71.4%, p<0.05). Vitamin C intake was significantly higher in the remission than in the relapse group (p<0.05). Although there were no obvi ous differences in enterobacterial flora between the remission and relapse groups, there was a relationship among enterobacte rial flora, diet, and UC progression. Given that the enterobacterial flora was only analyzed at the initiation of the study, we conclude that in future analyses, enterobacterial flora should be sampled at numerous time points to examine its role in UC progression. Further long term longitudinal studies examining enterobacterial flora, dietary factors, and UC progression are also required.

Induction of mucosal healing by intensive granulocyte/monocyte adsorptive apheresis (GMA) without use of corticosteroids in patients with ulcerative colitis: long-term remission maintenance after induction by GMA and efficacy of GMA re-treatment upon relapse

“…(1) Although there is increasing evidence showing associations with genetic, immune system, and environmental factors, as well as possible microbiota involvement in the pathogenesis of UC, those details remain unclear. (2)(3)(4) Nevertheless, several pharmacological agents proven to provide benefits for the condition have been developed, with 5aminosalicylic acid (5-ASA) the first choice for those with mild to moderate UC. (5) Should that fail, treatment with corticosteroids (CS) is usually then initiated.…”

Targeted deletion of Atg5 in intestinal epithelial cells promotes dextran sodium sulfate-induced colitis

“…(14) Recent studies have suggested an association of autophagy and ER stress in the pathophysiology of IBD. (15)(16)(17) For example, enhanced ER stress is observed in the Paneth cells of CD patients with SNP of the ATG16L1 gene. (18) The double knockout mice of ATG16L1 and XBP-1 develop spontaneous enterocolitis that resembles human IBD.…”