The assimilation of amino-acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in <i>Staphylococcus aureus</i>

Gale, E. F.; Folkes, Joan P.

doi:10.1042/bj0530493

Cited by 333 publications

(85 citation statements)

References 10 publications

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“…(c) Chloramphenicol-Treated Cdls.--When ceils are treated with chloramphenicol or aureomycin, the synthesis of proteins is inhibited (11,43). The synthesis of DNA, however, continues (13,43).…”

Section: (B) ]Vudeoids Of Starved Bacteria--growingmentioning

confidence: 99%

Electron Microscope Study of DNA-Containing Plasms

Kellenberger

Ryter

Séchaud

1958

The Journal of Cell Biology

976

136

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The nucleoids of Eseherichia coil, independently of the physiological state of the bacteria, are shown to be preserved as a fine-stranded fibrillar nucleoplasm by an OsO4 fixation under defined conditions: acetate-veronal buffer pH 6, presence of Ca ++ and amino acids, stabilization with uranyl-acetate before dehydration. The same fixation procedure applied to the DNA of vegetative phage reveals a pool of homogeneous fibrillar structure very similar to the nucleoplasm. The "versene test," which produces a coarse coagulation of these plasms, emphasizes the similar behaviour of the pool and the nucleoids.The heads of mature phage are preserved in their true polyhedral shape by the standard fixation procedure, although they may be badly distorted when fixed under different conditions. Lanthanum nitrate and uranyl-acetate are shown to increase markedly the contrast of both phage and cytoplasm.The consequences of the fibrillar structure of the genetic material are discussed in relation to the probable division process.

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Section: (B) ]Vudeoids Of Starved Bacteria--growingmentioning

confidence: 99%

Electron Microscope Study of DNA-Containing Plasms

Kellenberger

Ryter

Séchaud

1958

The Journal of Cell Biology

976

136

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“…Chloramphenicol (CAP) is a known protein synthesis inhibitor in bacteria [1][2][3] which has been shown to inhibit the puromycin reaction [4--8]. This inhibition suggests that CAP's action occurs at or before the peptide bond forming step.…”

Section: Introductionmentioning

confidence: 99%

The distribution of ¹⁴C‐proline peptides synthesized in vitro directed by polycytidylic acid; the effect of chloramphenicol

Irvin

Julian

1970

FEBS Letters

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“…Investigations have shown the compound is a strong inhibitor of protein synthesis (Gale & Folkes, 1953 Bernlohr 62 Webster, 1958). However, there is a lack of agreement about the effect of the drug on nucleic acid synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…However, there is a lack of agreement about the effect of the drug on nucleic acid synthesis. Gale & Folkes (1953) showed that chloramphenicol stimulated nucleic acid production in Staphylococcus aureus. Wisseman d al.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chloramphenicol on Protein and Nucleic Acid Synthesis by Shigella flexneri

Yee

Pan

Gezon

1962

Journal of General Microbiology

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SUMMARYResting organisms of Shigella jlexneri 3 were able to synthesize protein and nucleic acids in a chemically defined medium. Protein synthesis was markedly inhibited while ribonucleic acid (RNA) synthesis was stimulated by low concentrations of chloramphenicol ; deoxyribonucleic acid synthesis was inhibited slightly. Neither glycine, L-phenylalanine nor L-tyrosine annulled the action of the antibiotic. Inhibition of protein synthesis and stimulation of RNA synthesis in resting organisms of a chloramphenicol-resistant mutant of S. jexneri 3 was observed only in the presence of high concentrations of chloramphenicol. The results presented in this papcr show that chloramphenicol suppresses the growth of S . j l e x w i 3 by inttdering with the synt1,esis of protein. The stimulation of RNA synthesis suggests that chloramphenicol may exert its inhibitory action by promoting the formation of RNA with altered biological activity.

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The assimilation of amino-acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus

Cited by 333 publications

References 10 publications

Electron Microscope Study of DNA-Containing Plasms

Electron Microscope Study of DNA-Containing Plasms

The distribution of ¹⁴C‐proline peptides synthesized in vitro directed by polycytidylic acid; the effect of chloramphenicol

Effect of Chloramphenicol on Protein and Nucleic Acid Synthesis by Shigella flexneri

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The assimilation of amino-acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus

Cited by 333 publications

References 10 publications

Electron Microscope Study of DNA-Containing Plasms

Electron Microscope Study of DNA-Containing Plasms

The distribution of 14C‐proline peptides synthesized in vitro directed by polycytidylic acid; the effect of chloramphenicol

Effect of Chloramphenicol on Protein and Nucleic Acid Synthesis by Shigella flexneri

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The distribution of ¹⁴C‐proline peptides synthesized in vitro directed by polycytidylic acid; the effect of chloramphenicol