The assignment of absolute configurations to the individual enantiomorphs of phenylpropylmethylamine and pipradrol hydrochloride

Abstract

The configuration of the C-2 asymmetric centre of (—)-phenylpropylmethylamine (N-methyl-2-phenylpropylamine) has been related by a stereospecific route to that of the analogous centre of (+)-(S)-hydratropic acid. The configuration at the C-2 asymmetric centre of (—)-pipradrol (diphenylpiperid-2-ylmethanol) hydrochloride has been related by a stereospecific route to that of the analogous centre of (+)-(R)-pipecolic acid.