The assessment of spectral Doppler parameters in uterine arteries of patients with locally advanced squamous cell cervical cancer

Abstract

Objectives: Evaluate spectral Doppler parameters peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI) and pulsatility index (PI) in infiltrated and non-infiltrated uterine arteries of patients with locally advanced (stages II B, III B) squamous cell cervical cancer and their changes during treatment.Material and methods: the study group included 36 patients aged 35-78 years old. At diagnosis, PSV, EDV, RI and PI in uterine arteries were examined and compared with MRI findings. All patients underwent transvaginal doppler ultrasonography prior to the treatment, after external beam radiation therapy and six weeks after the last application of brachytherapy. Results:The median PSV value in the first examination was higher in infiltrated uterine arteries than compared to non-infiltrated ones (p = 0.001). The PSV values for all vessels decreased between the first and the third observation (p < 0.001). There was a significant difference in PI values between infiltrated and non-infiltrated uterine arteries between the first and the third examination (p = 0.027). Conclusions:In patients with locally advanced cervical cancer of uterine arteries, assessment of PSV but not EDV, RI or PI can be helpful in differentiating infiltrated from non-infiltrated vessels. In this group of patients, radiotherapy decreases PSV, but not EDV, RI or PI values in uterine arteries. An observation conducted from the onset of radiotherapy to end of the follow-up in uterine arteries reveals that PI, but not RI, PSV or EDV, is different in infiltrated and non-infiltrated vessels.

Diagnosis Value of Colposcope Combined with Serum Squamous Cell Carcinoma Antigen, Carbohydrate Antigen 125, and Carcinoembryonic Antigen for Moderate to Advanced Cervical Cancer Patients Treated with Modified Fuzheng Peiyuan Decoction

“…Colposcopy is an imaging means currently used to screen for precancerous cervical lesions, which can amplify the image of the cervix and vagina mucosa, enable more precise visualization of tiny lesions, vascular tissue, and suspicious areas on the surface of the cervix that are not visible to the naked eye, and localize the biopsy to improve test accuracy. erefore, combining colposcopy with serum detection can eliminate problems such as unnecessary treatment for false positive patients and ensure safety, reliability, and strong operability, which is suitable for clinical diagnosis and efficacy determination [24]. In this study, the efficacy of Fuzheng Peiyuan decoction in the treatment of moderate to advanced cervical cancer was evaluated by the combined test, and by plotting the ROC curve, it was found that combined test had an area under the curve larger than each single test, and high sensitivity, and specificity, and therefore it might serve as an effective diagnostic modality to objectively evaluate the treatment effect of cervical cancer patients.…”

Are IgG antibodies to heat shock proteins HSP27 and HSP60 useful markers in endometrial cancer and cervical cancer?

“…Various studies have shown that persistent HPV infection is a major causative factor in cervical cancer, but only a small proportion of patients with HPV infection will eventually progress to cervical cancer. In cervical cancer patients, the mode of treatment depends on staging and parametrial infiltration, which is a critical factor in determining treatment planning [10]. Etiological studies have shown that the occurrence of this cancer is a complicated process that includes many factors, and its molecular mechanism has not yet been fully explained.…”