The assessment of prognostic factors in surgical treatment of low-grade gliomas: A prospective study

Majchrzak, Krzysztof; Kaspera, Wojciech; Bobek-Billewicz, Barbara; Hebda, Anna; Stasik-Pres, Gabriela; Majchrzak, H; Ładziński, Piotr

doi:10.1016/j.clineuro.2012.02.054

Cited by 56 publications

(52 citation statements)

References 43 publications

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“…In our material, the extent of tumour resection in the ST group was significantly higher compared to the AT group. The extent of tumour resection significantly influenced progression-free survival (PFS) and overall survival (OS) in LGG patients, which is consistent with the reports of other researchers [19,31,43]. Our observations confirm that next to the extent of resection, excision of contrast enhancement area is essential for further course of disease.…”

Section: Discussionsupporting

confidence: 81%

Original article Anaplastic transformation of low-grade gliomas (WHO II) on magnetic resonance imaging

Bobek-Billewicz¹,

Stasik-Pres²,

Hebda³

et al. 2014

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Section: Discussionsupporting

confidence: 81%

Original article Anaplastic transformation of low-grade gliomas (WHO II) on magnetic resonance imaging

Bobek-Billewicz¹,

Stasik-Pres²,

Hebda³

et al. 2014

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“…While the largest investigation addressing this aspect by Capelle et al suggested a residual tumor volume of less than 10 cm 3 to be the crucial factor for a good prognosis, in particular due to a delay of anaplastic transformation21, others have suggested different percentages of tumor removal/residual tumor that proved valuable282930313233. In light of the present study, we clearly challenge the notion, that any surgical intervention improves patient survival in DLGG.…”

Section: Discussioncontrasting

confidence: 44%

Residual Tumor Volume as Best Outcome Predictor in Low Grade Glioma – A Nine-Years Near-Randomized Survey of Surgery vs. Biopsy

Roelz

Strohmaier

Jabbarli

et al. 2016

Sci Rep

119

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Diffuse low grade gliomas (DLGG) are continuously progressive primary brain neoplasms that lead to neurological deficits and death. Treatment strategies are controversial. Randomized trials establishing the prognostic value of surgery do not exist. Here, we report the results of a nine-year near-randomized patient distribution between resection and biopsy. Until 2012, the Department of Neurosurgery and the Department of Stereotactic Neurosurgery at the University Medical Center Freiburg were organized as separate administrative units both coordinating DLGG patient treatment independently. All consecutive adult patients with a new diagnosis of DLGG by either stereotactic biopsy or resection were included. Pre- and post-operative tumor volumetry was performed. 126 patients, 87 men (69%), 39 women (31%), median age 41 years, were included. 77 (61%) were initially managed by biopsy, 49 (39%) by resection. A significant survival benefit was found for patients with an initial management by resection (5-year OS 82% vs. 54%). The survival benefit of patients with initial resection was reserved to patients with a residual tumor volume of less than 15 cm3. Maximum safe resection is the first therapy of choice in DLGG patients if a near-complete tumor removal can be achieved. Accurate prediction of the extent-of-resection is required for selection of surgical candidates.

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“…Jung et al showed that the 5-year OS and PFS were 81% and 57%, respectively (6). The 5-year OS was 91% and the 5-year PFS was 68% in Majchrzak et al's prospective study (26). These differences can be associated with heterogeneous clinical behavior of LGGs and retrospective design of the studies.…”

Section: Discussionmentioning

confidence: 98%

Prognostic factors for survival in adult patients with grade II glial tumors

Önder¹,

Kanyılmaz²,

Aktan³

et al. 2018

J Turgut Ozal Med Cent

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Aim: To investigate survival results of patients with low grade gliomas (LGGs) and to evaluate the predictive role of clinico-pathologic prognostic factors on survival. Material and Methods: Between 2003 and 2014, the adult patients with Grade II glial tumors were evaluated retrospectively. Several variables were investigated to find prognostic factors related with the overall survival (OS) and progression-free survival (PFS).Results: This study involved in 124 patients with median 40 (range; 6-132) months follow up. The average OS for the all patients was 7.8 years. 2-, 5-and 10-year OS ratios were 91%, 73% and 55%, respectively. Patients with low pignatti risk score had a longer OS than high pignatti risk score (p=0.01). Patients with seizure had a better OS (p=0.03). Patients with biopsy/partial resection had a poorer OS (p=0.02). Patients with residue after initial surgery had a worse OS (p=0.03). If the patients had recurrence or progression, the patients had poorer OS (p=0.01). Tumor with malignant transformation (p=0.01) and glioblastoma subtype after second surgery (p=0.003) had a poorer OS. The Pignatti risk score and seizure were the independent prognostic factors for PFS. Conclusion:The extent of surgery and recurrence or progression of Grade II glioma were the independent prognostic factors for OS. The Pignatti risk score and seizure were the independent prognostic factors for PFS.

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The assessment of prognostic factors in surgical treatment of low-grade gliomas: A prospective study

Cited by 56 publications

References 43 publications

Original article Anaplastic transformation of low-grade gliomas (WHO II) on magnetic resonance imaging

Original article Anaplastic transformation of low-grade gliomas (WHO II) on magnetic resonance imaging

Residual Tumor Volume as Best Outcome Predictor in Low Grade Glioma – A Nine-Years Near-Randomized Survey of Surgery vs. Biopsy

Prognostic factors for survival in adult patients with grade II glial tumors

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