The assessment of hemispheric lateralization in functional MRI—Robustness and reproducibility

Jansen, Andreas; Menke, Ricarda; Sommer, Jens; Förster, Ann-Freya; Bruchmann, S.; Hempleman, J.; Weber, Bernd; Knecht, Stefan

doi:10.1016/j.neuroimage.2006.06.019

Cited by 204 publications

(220 citation statements)

References 47 publications

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“…To define our ROI's, we started from masked t-maps. To take inter-subject variability into account, we adjusted the threshold for the activation pixels for each subject using a technique that was introduced earlier by a number of other authors in order to improve the robustness of lateralization measures [22,33,35]. For each amygdala, we calculated a mean maximum t defined as the mean of the 5% highest t-values.…”

Section: Image Acquisition and Data Analysismentioning

confidence: 99%

Right prefrontal HF-rTMS attenuates right amygdala processing of negatively valenced emotional stimuli in healthy females

Baeken

Raedt

Schuerbeek

et al. 2010

Behavioural Brain Research

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Repetitive Transcranial Magnetic Stimulation (rTMS) studies investigating brain imaging correlates of emotion modulation in healthy volunteers can improve our understanding of the 'affective' impact of this application. In this fMRI study, we focused on lateralized amygdala functioning when processing salient emotional visual stimuli after one high-frequency (HF)-rTMS session. In a 'uniform sample' of 20 right-handed, non-depressed, healthy female subjects we examined whether one HF-rTMS session applied to the left (n=10) or right (n=10) dorsolateral prefrontal cortex (DLPFC) would influence amygdala responses to positively and negatively valenced baby faces. Subjects were given no other instructions than to focus on the emotion the visual stimuli elicited during scanning. One HF-rTMS session did not result in a conscious mood change. Whereas one left-sided HF-rTMS session did not affect amygdala processing of the positive or negative stimuli, after a single rightsided HF-rTMS session we found a significant right amygdala activity attenuation during the processing of negatively valenced baby faces. This finding provides additional evidence supporting the role of the right anterior hemisphere in the processing of negative emotional information, and increases our understanding of HF-rTMS treatment effects in mental disorders.3

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Section: Image Acquisition and Data Analysismentioning

confidence: 99%

Right prefrontal HF-rTMS attenuates right amygdala processing of negatively valenced emotional stimuli in healthy females

Baeken

Raedt

Schuerbeek

et al. 2010

Behavioural Brain Research

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“…By using the WFU PickAtlas Tool Version, 2.4 (Maldjian et al, 2003), we defined maskvolumes which masked all brain activations except those in the left or right Cg25 7 containing both activated and non-activated voxels in proportions depending on the general activity level of each individual. To take this inter-subject variability into account, we adjusted the threshold for the activation pixels for each subject using a technique that was introduced earlier by a number of other authors in order to improve the robustness of lateralization measures (Fernández et al, 2001;Knecht et al, 2003;Jansen et al, 2006). In a first step, we calculated the means of the 5% highest T-values in the left and right Cg25 regions as defined by the mask.…”

Section: Image Acquisition and Data Analysismentioning

confidence: 99%

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Baeken

Schuerbeek

Raedt

et al. 2010

Journal of Affective Disorders

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Background: Research regarding the neurocircuitry in mood disorders suggests an important role for affective information processing of the subgenual part of the anterior cingulate cortex (Cg25: Brodmann area 25).Objective: In this study, we focused on Cg25 neuronal responses in depressed females using a paradigm in which emotions are elicited without explicit cognitive control, relying on the salient nature of the mood inducing stimuli eliciting approach-related emotions (like happiness) or withdrawal-related emotions (like disgust).Methods: Twelve treatment-resistant melancholic depressed women and 12 healthy female control subjects were asked to passively view blocks of emotionally valenced baby faces while undergoing functional magnetic resonance imaging (fMRI).Results: Compared to the healthy females, the depressed patients displayed significantly higher bilateral Cg25 neuronal activities in both emotional conditions. In melancholically depressed women, we found significantly less left-sided than right-sided Cg25 neuronal activity during the withdrawal-related emotions, while right-sided Cg25 activity was comparable for both emotional responses.

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“…31 Different methods for calculating LI have been used for determination of language dominance by fMRI. 50 For this study, we used calculations of a regional LI for the region of interest pairs Broca/BR and Wernicke/WR to achieve reliable and more detailed information compared with a global LI calculation. Furthermore, for the determination of language dominance, it has been shown that regional LI correlates better with the results of Wada testing compared with global LI, which is based on voxel counts of the complete hemisphere.…”

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confidence: 99%

Clinical Standardized fMRI Reveals Altered Language Lateralization in Patients with Brain Tumor

Partovi

Jacobi

Rapps

et al. 2012

AJNR Am J Neuroradiol

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The assessment of hemispheric lateralization in functional MRI—Robustness and reproducibility

Cited by 204 publications

References 47 publications

Right prefrontal HF-rTMS attenuates right amygdala processing of negatively valenced emotional stimuli in healthy females

Right prefrontal HF-rTMS attenuates right amygdala processing of negatively valenced emotional stimuli in healthy females

Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients

Clinical Standardized fMRI Reveals Altered Language Lateralization in Patients with Brain Tumor

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