While dealing with the problem of congenital cardiac malformations in perinatology, we noted that the intrauterine cephalometric measurements in infants with transposition of the great vessels, observed during the second trimester of pregnancy, were abnormal [4]. It was assumed 'that at this time of gestation, pathology was more likely caused by reduced potential of fetal growth rather than by placental insufficiency [1]. This finding lead us to conduct a retrospective study of the cases with pathological cephalometry in the micUtrimester and to evaluate the meaning äs well äs the prognostic significance of abnormal fetal development prior to the 28th week of gestation.
Methods and materialThe routine examination was carried out using the echoscopic (Vidoson 635, B-scan, SIEMENS, W. Germany) and ultrasonographic (A-and B-transverse scan, KRETZ 4100, Austria) methods [3]. The evaluation of the fetal biparietal diameter was done with reference to our Standard curve ( fig. 1) cephalometry and 164 (11%) with pathological measurements. In 69 cases (4.6%) with abnormal biparietal measurements, it was necessary to readjust the estimated gestational age, while the remaining 95 cases (6.9%) were considered for further analysis. From the 95, 61 cases were below and 34 cases above our SIUBG.
Results
Cases with measurements below SIUBG (tab. 1)20 (33%) Small-for-date infants (under 10 percentiles according to THOMSON) 10 (17%) Fetuses died before the 28th week.of gestation 8 (18%) imminent abortion (pathological placentation) 7 (11%) Malformations ! p < 0,01 16 (26%) Normal infants after normal pregnancies Tab. 1. Abnormal cephalometry in the 2nd trimester of pregnancy below SIUBG (n = 61).
J. Perinat. Med. 2 (1973)Ramzin et al., Prognostic significance of abnormal ultrasonographic findings during the second trimester of gestation 61 Twenty infants from the selected group of 61 were severely retarded (with birth weight under 10 percentiles according to THOMSON [6]). The retardation was found to have occurred prior to the 24th week of gestation and was probably due to reduced fetal growth potential. Ten infants died before the beginning of the 28th week of gestation. A study of the case history of these patients revealed infertility in 6 cases. In 8 cases, the pregnancy was disturbed by faulty placentation, causing retroplacental hemorrhages, äs confirmed by ultrasonic exploration. One of those cases is shown in fig. 2. Seven infants were malformed and in 16 cases pregnancy proceded normally with healthy newborns. Statistical analysis showed that the rate of fetal pathology had increased significantly (p < 0.01) in cases with early retarded biparietal growth (tab. 1).
Cases with measurements above SIUGB (tab. 2)Among the infants with biparietal diameters above our SIUBG in the mid-trimester we found:13 (38%) Large-for-date infants (over 90 percentiles according to THOMSON) 6 (17%) Malformations p > 0,05 15 (45%) Normal infants after normal pregnancics Tab. 2. Abnormal cephalometry in the 2nd trimester of pregnancy above SIU...