The aspirin resistance and platelets` receptors expression in chronic heart failure patients with type 2 diabetes mellitus

Kolesnyk, M. Yu.; Syvolap, V. V.

doi:10.14739/2310-1210.2014.3.25594

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Previous research showed that the incidence of aspirin resistance increased in patients with chronic heart failure (CHF) and decompensated type 2 diabetes mellitus (DM2). PLUTO-CHF trial observed higher platelet activity in patients with CHF treated with ASA [ 20 , 21 ]. However, there are results presented in the literature that find that the highest platelet aggregation is found in functional NYHA III class patients.…”

Section: Discussionmentioning

confidence: 99%

N-Terminal Pro-Brain Natriuretic Peptide and Right Ventricular Diameter Are Related to Aspirin Resistance in Coronary Artery Disease Patients

et al. 2021

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Background and Objectives: Resistance to ASA (ASAres) is a multifactorial phenomenon defined as insufficient reduction of platelet reactivity through incomplete inhibition of thromboxane A2 synthesis. The aim is to reassess the prevalence and predictors of ASAres in a contemporary cohort of coronary artery disease (CAD) patients (pts) on stable therapy with ASA, 75 mg o.d. Materials and Methods: We studied 205 patients with stable CAD treated with daily dose of 75 mg ASA for a minimum of one month. ASAres was defined as ARU (aspirin reaction units) ≥550 using the point-of-care VerifyNow Aspirin test. Results: ASAres was detected in 11.7% of patients. Modest but significant correlations were detected between ARU and concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) (r = 0.144; p = 0.04), body weight, body mass index, red blood cell distribution width, left ventricular mass, and septal end-systolic thickness, with trends for left ventricular mass index and prothrombin time. In multivariate regression analysis, log(NT-proBNP) was identified as the only independent predictor of ARU—partial r = 0.15, p = 0.03. Median concentrations of NT-proBNP were significantly higher in ASAres patients (median value 311.4 vs. 646.3 pg/mL; p = 0.046) and right ventricular diameter was larger, whereas mean corpuscular hemoglobin concentration was lower as compared to patients with adequate response to ASA. Conclusions: ASAres has significant prevalence in this contemporary CAD cohort and NT-proBNP has been identified as the independent correlate of on-treatment ARU, representing a predictor for ASAres, along with right ventricular enlargement and lower hemoglobin concentration in erythrocytes.

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Section: Discussionmentioning

confidence: 99%