The ascending rank of chronic kidney disease in the global burden of disease study

Jager, Kitty J.; Fraser, Simon

doi:10.1093/ndt/gfw330

Cited by 140 publications

(101 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In recent years, because of the rising ageing population and the ascending prevalence of predisposing conditions such as hypertension, diabetes and obesity, the population of patients receiving dialysis grew rapidly (Jager & Fraser 2017). In the United States, about 500 000 Americans were receiving maintenance dialysis in 2015 (Saran et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Relationships among social support, empathy, resilience and work engagement in haemodialysis nurses

Cao

Chen

2019

International Nursing Review

View full text Add to dashboard Cite

Aim To describe the levels of work engagement, and to analyse the reciprocal relationships between social support, empathy, resilience and work engagement among haemodialysis nurses in China. Background Work engagement is a critical workplace health indicator. Previous studies have examined work engagement perceived by nurses working in diverse hospital wards, or a specialty area (emergency care or intensive care), no previous studies have highlighted work engagement and its affecting factors among haemodialysis nurses. Methods Participants in the cross‐sectional study were 345 haemodialysis nurses employed in 17 hospitals in Chengdu, China. Hierarchical regression analyses were carried out to analyse the relationships between social support, empathy, resilience and work engagement in haemodialysis nurses. Results Resilience was the strongest positive significant contributor to work engagement, followed by other support and perspective taking (cognitive empathy). Nurses with longer occupational tenure reported higher levels of work engagement. Male nurses also reported greater work engagement than female nurses. Discussion Influence of work engagement was explored by social support, empathy and resilience, reflecting the need of haemodialysis nurses to understand the significance of focusing on their personal and environmental factors. Conclusions Positive resilience, other support and cognitive empathy can result in increased work engagement. Implications for nursing Training programs, such as mindfulness meditation training and empathy skills training, are recommended for nursing managers to enhance resilience and empathic capacity in nurses. Implications for nursing policy Nursing policies should be developed to establish supportive work environments in clinical practice settings and to support the education and training of psychological resilience and empathic capacity in order to foster work engagement.

show abstract

Section: Introductionmentioning

confidence: 99%

Relationships among social support, empathy, resilience and work engagement in haemodialysis nurses

Cao

Chen

2019

International Nursing Review

View full text Add to dashboard Cite

show abstract

“…Chronic kidney disease is defined as a persistent loss of renal function and is a growing global health problem, affecting~13% of the world's population (Jager & Fraser, 2017). Renal fibrosis occurs in both the glomerulus (glomerulosclerosis) and the tubulointerstitium and is the final common pathway for a diverse range of aetiologies which lead to chronic kidney disease (including infection, ischaemia, diabetes, autoimmune disease, physical obstruction of the urinary tract and toxic or drug insults; Djudjaj & Boor, 2019;Knoppert, Valentijn, Nguyen, Goldschmeding, & Falke, 2019).…”

mentioning

confidence: 99%

IL‐11 in cardiac and renal fibrosis: Late to the party but a central player

Corden

Adami

Sweeney

et al. 2020

British J Pharmacology

View full text Add to dashboard Cite

Fibrosis is a pathophysiological hallmark of cardiorenal disease. In the heart, fibrosis leads to contractile dysfunction and arrhythmias; in the kidney, it is the final common pathway for many diseases and predicts end‐stage renal failure. Despite this, there are currently no specific anti‐fibrotic treatments available for cardiac or renal disease. Recently and unexpectedly, IL‐11 was found to be of major importance for cardiorenal fibroblast activation and fibrosis. In mouse models, IL‐11 overexpression caused fibrosis of the heart and kidney while genetic deletion of Il11ra1 protected against fibrosis and preserved organ function. Neutralizing antibodies against IL‐11 or IL‐11RA have been developed that have anti‐fibrotic activity in human fibroblasts and protect against fibrosis in murine models of disease. While IL‐11 biology has been little studied and, we suggest, largely misunderstood, its autocrine activity in myofibroblasts appears non‐redundant for fibrosis, which offers new opportunities to better understand and potentially target cardiorenal fibrosis.

show abstract

“…Chronic kidney disease (CKD) is defined based on the presence of renal damages and decrease in renal function (1). It affects 10% of adult population, and the prevalence of CKD is still increasing because of population aging, diabetes, hypertension, and other causes (1,2). Tubulointerstitial fibrosis is a major hallmark of CKD, which is driven by renal tubule injuries (3).…”

mentioning

confidence: 99%

Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys

Peng

Lin

et al. 2019

FASEB j.

View full text Add to dashboard Cite

The role of asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD) is unclear. Through inhibition of type I protein arginine methyltransferases (PRMTs), a novel strategy, we aimed to determine the effect of ADMA on renal fibrosis and explore its underlying working mechanisms. After sham or unilateral ureter ligation (UUO) operation, 20–25 g male c57 mice were treated with vehicle or PT1001B, an inhibitor of type I PRMTs, for 13 d. Moreover, human kidney 2 (HK2) and normal rat kidney 49F (NRK‐49F) cells were treated with various concentrations of PT1001B or ADMA in the presence of 2.5 ng/ml TGF‐β. We found that treatment with PT1001B increased the deposition of extracellular matrix proteins, the expression of αsmooth muscle actin, and connective tissue growth factor in UUO‐induced fibrotic kidneys, which is correlated with reduced expression of PRMT1, reduced the production of ADMA, and increased expression of uromodulin. In TGF‐β‐stimulated HK2 and NRK‐49F cells, PT1001B dose‐dependently inhibited ADMA production, increased NO concentrations, and enhanced the expression of profibrotic proteins. Exogenous addition of ADMA inhibited the expression of profibrotic proteins dose‐dependently and attenuated the profibrotic effect of PT1001B. Moreover, ADMA reduced the NO concentration in PT1001B‐treated HK2 cells. Finally, we conclude that ADMA has an antifibrotic effect in obstructed kidneys, and future application of type I PRMT inhibitor should be done cautiously for patients with CKD.—Wu, M., Lin, P., Li, L., Chen, D., Yang, X., Xu, L., Zhou, B., Wang, C., Zhang, Y., Luo, C., Ye, C. Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys. FASEB J. 33, 6948–6956 (2019). http://www.fasebj.org

show abstract

The ascending rank of chronic kidney disease in the global burden of disease study

Abstract: Word Count: 267References: 35

Cited by 140 publications

References 27 publications

Relationships among social support, empathy, resilience and work engagement in haemodialysis nurses

Relationships among social support, empathy, resilience and work engagement in haemodialysis nurses

IL‐11 in cardiac and renal fibrosis: Late to the party but a central player

Reduced asymmetric dimethylarginine accumulation through inhibition of the type I protein arginine methyltransferases promotes renal fibrosis in obstructed kidneys

Contact Info

Product

Resources

About