The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration

Casado, Fanny L.

doi:10.1155/2016/4389802

Cited by 16 publications

(11 citation statements)

References 66 publications

(65 reference statements)

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“…Restoration of butyrate, which is diminished in intestinal epithelial cells (IECs) after allo-HCT, improved IEC junctional integrity, decreased apoptosis, and mitigated GVHD ( 66 ). Aryl hydrocarbon receptor (AhR) is a cellular metabolic sensor ( 72 ). AhR ligands are derived from intestinal microbiota metabolism.…”

Section: Microbiota Regulates T Cell Metabolismmentioning

confidence: 99%

T-Cell Metabolism in Hematopoietic Cell Transplantation

et al. 2018

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Metabolism, including catabolism and anabolism, is a basic cellular process necessary for cell survival. T lymphocytes have a distinct metabolism that can determine both fate and function. T-cell activation depends on glycolysis to obtain materials and energy for proliferation and effector function. Importantly, T cells utilize different metabolic processes under different conditions and diseases. Allogeneic hematopoietic cell transplantation (allo-HCT) is a classic immunotherapy for hematological malignancies; however, the development of graft-versus-host disease (GVHD) is a major factor limiting the success of allo-HCT. T cells in the donor graft drive GVHD by mounting a robust immunological attack against recipient normal tissues. Hence, understanding T-cell metabolism after allo-HCT would provide potential metabolic targets for the control of GVHD and primary tumor relapse. The purpose of the current review is to highlight the key metabolic pathways involved in alloantigen-activated T cells and to discuss how manipulating these pathways can serve as potential new therapeutic strategies to induce immune tolerance after allo-transplantation. We will also summarize the recent progress in regulating T-cell metabolism in bone marrow transplantation by targeting novel metabolic regulators or immune checkpoint molecules.

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Section: Microbiota Regulates T Cell Metabolismmentioning

confidence: 99%

T-Cell Metabolism in Hematopoietic Cell Transplantation

et al. 2018

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“…in the context of aging and diseases [68]. In addition, AHR regulates CYP1B1 [69], which belongs to the cytochrome P450 superfamily of enzymes.…”

Section: Resultsmentioning

confidence: 99%

“…Their involvement in various cancer-associated processes is also well-known [ 66 , 67 ]. AHR is a ligand-activated transcription factor, which may interact with different pathways regulating cellular homeostasis including cellular regeneration in the context of aging and diseases [ 68 ]. In addition, AHR regulates CYP1B1 [ 69 ], which belongs to the cytochrome P450 superfamily of enzymes.…”

Section: Resultsmentioning

confidence: 99%

Medicinal Properties of Lilium candidum L. and Its Phytochemicals

Zaccai

Yarmolinsky²,

Khalfin

et al. 2020

Plants

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Lilium candidum L., known as Madonna, meadow, or white lily, is a bulbous plant from the Liliaceae family, originating in the Middle East. L. candidum has been abundantly used in folk medicine since ancient times to relieve a variety of ailments, including age-related diseases, burns, ulcers, and coughs. The aim of this article is to investigate the anti-inflammatory and anti-diabetic activities of L. candidum extracts and its active phytochemicals. Some active volatile phytochemicals were identified using gas chromatography–mass spectrometry (GC-MS) analysis. Significant (p < 0.001) anti-diabetic properties of the extracts kaempferol, linalool, citronellal, and humulene were demonstrated by an elevation in glucose uptake by adipocytes. The significant (p < 0.01) effect of the plant extracts kaempferol, citronellal, and humulene on the secretion of pro-inflammatory cytokines interleukin 6 (IL-6) and interleukin 8 (IL-8) was demonstrated using enzyme-linked immunosorbent assay. Altogether, L. candidum and its rich collection of phytochemicals hold promising medicinal potential, and further investigations of its therapeutic prospects are encouraged.

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“…The characterization of this pathway indeed becomes more complex given the evidence that the role of AhR pathway in self-renewal is cell context and differentiation stage specific. 73,74 A phase I/II clinical study performed with one unmanipulated UCB unit and the progeny of the CD34 + cells from another UCB unit treated for 15 days ex vivo with SR1 demonstrated rapid neutrophil and platelet recovery. Importantly, this recovery was significantly more rapid than in patients receiving only the unmanipulated UCB.…”

Section: Ex Vivo Expansion Of Ucb-cd34 + Cells With the Aryl Hydrocarmentioning

confidence: 99%

“…Although this evidence clearly implicates the AhR pathway in HSC metabolism and hematopoiesis, additional studies are needed to precisely understand the role of the AhR in the self‐renewal of human HSCs. The characterization of this pathway indeed becomes more complex given the evidence that the role of AhR pathway in self‐renewal is cell context and differentiation stage specific …”

Section: Ex Vivo Expansion Of Ucb‐cd34+ Cells With the Aryl Hydrocarbmentioning

confidence: 99%

Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis

Papa

Djedaini

Hoffman

2019

Annals of the New York Academy of Sciences

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Understanding mechanisms that determine the behavior of human hematopoietic stem cells (HSCs) is essential for developing novel strategies to expand ex vivo the number of fully functional HSCs. In this review, we focus on the complex interplay between intrinsic mechanisms regulated by transcriptional and mitochondrial networks and extrinsic signals imposed by the bone marrow microenvironment, which in concert regulate the balance between HSC self-renewal and differentiation. Such integrated signaling mechanisms that dictate the fate of HSCs in vivo must be recapitulated ex vivo to achieve successful expansion of clinically relevant HSCs. We also highlight some of the most recent ex vivo HSC expansion strategies that have currently entered clinical development. Finally, based on the evidence reviewed here and lessons learned from ex vivo HSC expansion, we raise some critical questions regarding HSC fate and the cellular plasticity of hematopoietic cells that challenge the unidirectional model of human hematopoiesis.

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The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration

Cited by 16 publications

References 66 publications

T-Cell Metabolism in Hematopoietic Cell Transplantation

T-Cell Metabolism in Hematopoietic Cell Transplantation

Medicinal Properties of Lilium candidum L. and Its Phytochemicals

Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis

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