The Artificial Pancreas

Radziuk, J.

doi:10.2337/db12-0647

Cited by 8 publications

(5 citation statements)

References 18 publications

(23 reference statements)

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“…The gut epithelium limits insulin absorption. All of these factors contribute to low bioavailability and substantial inter-and intra-subject variability (41)(42)(43)(44)(45)(46)(47)(48).…”

Section: Proposed Methods For Insulin Deliverymentioning

confidence: 99%

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Saha

Sultana

Yesmin

et al. 2021

Avicenna J Pharm Res

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Diabetes is one of the major medical problems in the world. The discovery of insulin was a milestone in the history of medical science. This legendary invention has completed 100 years of its journey. Through this 100-year journey, many important events have taken place, and many modifications have been made to make it convenient for commercialization and patient compliance. After the antidiabetic activity of the pancreatic extract was discovered, the bovine and pork insulin came into use. Then, recombinant human insulin was discovered. Now long-acting to rapid-acting insulin forms are available (e.g., insulin pens, insulin pumps, and the like), and different systems are in use to deliver them to the body, but all these insulins are in invasive dosage forms and have some disadvantages, too. As we are using the oral form of most medicines, we prefer the oral form of insulin. Therefore, the concern is now to develop the oral dosage form of insulin. Some proposed oral dosage forms are at different stages of the clinical trial such as classical dosage forms, enzyme inhibitors, unnatural amino acids, nanoparticles, cell-penetrating peptides, and so on. Since the oral forms of insulin create some limitations and confusion, further research is required to solve these problems. Accordingly, the aim of the review was to predict the possibility of developing marketable oral insulin.

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“…The gut epithelium limits insulin absorption. All of these factors contribute to low bioavailability and substantial inter-and intra-subject variability (41)(42)(43)(44)(45)(46)(47)(48).…”

Section: Proposed Methods For Insulin Deliverymentioning

confidence: 99%

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Saha

Sultana

Yesmin

et al. 2021

Avicenna J Pharm Res

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show abstract

“…The algorithms that are most relevant include the proportionalintegral-derivative control (PID) and the model-predictive control (MPC). [11] Several areas need improvement to have a near normal closed-loop system. First and foremost is the rapid onset of action.…”

Section: Future Trends (Table 1)mentioning

confidence: 99%

Insulin Therapy for Diabetes

Azad¹,

Isenović²,

Yaturu³

et al. 2013

Type 2 Diabetes

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“…Up to now, whatever insulin source (injection or even cell cultures) may be used, their principle has been based on an insulin delivery conditioned by a blood glucose monitoring [13][14][15][16][17][18][19][20]. The results have remained controversial.…”

Section: Introductionmentioning

confidence: 99%

A New Feed Back For Monitoring Insulin Therapy? (First Experimental and Clinical Tests)

Novikov¹

2015

Pancreat Disord Ther

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The Artificial Pancreas

Cited by 8 publications

References 18 publications

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Insulin Therapy for Diabetes

A New Feed Back For Monitoring Insulin Therapy? (First Experimental and Clinical Tests)

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