The arthropathy of relapsing polychondritis

O'Hanlan, Michael; McAdam, Lawrence P.; Bluestone, Rodney; Pearson, Carl M.

doi:10.1002/art.1780190210

Cited by 55 publications

(16 citation statements)

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“…Joint involvement is usually migratory, affecting large and small joints and often parasternal articulations. Generally, is is nonerosive and seronegative [25]. Nasal inflammation, laryngotracheal cartilage inflammation and ocular inflammation are less common at initial presentation and occur in approximately 20% of patients [17].…”

Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis presenting as cutaneous polyarteritis nodosa

et al. 1993

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Relapsing polychondritis is an infrequently diagnosed, though not necessarily uncommon, systemic disorder characterized by recurrent and potentially destructive inflammation of cartilaginous structures, the eye, and the audiovestibular and cardiovascular systems. Although dermal involvement occurs in approximately 25% of patients with relapsing polychondritis, in only few cases has a skin biopsy been obtained revealing lesions such as leukocytoclastic vasculitis, livedo reticularis, erythema nodosum or keratodermia blenorrhagicum. We describe a patient with relapsing polychondritis in whom a cutaneous polyarteritis nodosa preceded cartilage inflammation by 6 months. Cutaneous polyarteritis nodosa is a rare form of vasculitis that appears to be limited primarily to the skin, muscles, and joints. In contrast to the systemic form of the disease it is characterized by the absence of visceral lesions and a relapsing but benign course. The present case and the fact that vasculitis is a concomitant feature in approximately 30% of patients with relapsing polychondritis [21] demonstrates that this condition may not represent a distinct clinical entity.

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Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis presenting as cutaneous polyarteritis nodosa

et al. 1993

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“…The presence of polyarthritis in more than 80% of the patients with RP [8] might possibly also be explained by type-specific autoimmunity. A recent experiment has shown that intradermal injection of collagen type 11 whether isolated from articular cartilage or vitreous collagen induced a chronic polyarthritis in rats whereas collagen types I and III or proteo glycans were not arthritogenic [11].…”

Section: Discussionmentioning

confidence: 99%

Relapsing Polychondritis

Hedfors¹,

Hammar²,

Theorell³

1982

Dermatology

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“…Articular manifestations (arthralgia, arthritis, and costochondritis) may occur in 70%-80% of adult and pediatric patients 1-3. The most common pattern is episodic, asymmetric, nonerosive, nondeforming peripheral arthritis, lasting for weeks or months, commonly affecting ankles, wrists, PIP joints, metacarpophalangeal joints, elbows, and metatarsophalangeal joints [3][4][5] . Plain radiographs, in the absence of an associated disease, classically show only juxtaarticular osteopenia and minor uniform joint space narrowing, typically without erosive changes or deformities 6,7 .…”

Section: To the Editormentioning

confidence: 99%