The Arthropathy of Idiopathic Haemochromatosis

Hamilton, E. B. D.; Williams, Roger; Barlow, Keith A.; Smith, Peter

doi:10.1093/oxfordjournals.qjmed.a067135

Cited by 44 publications

(1 citation statement)

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“…Although ankle joint involvement is described in about one out of two patients with HH, as reported by Hamilton et al [ 19 ], there are not many studies in the literature regarding ankle arthropathy in HH. This might suggest that involvement of this joint may be underrecognized in HH or have a late presentation [ 20 ].…”

Section: Epidemiologymentioning

confidence: 99%

Overview of Ankle Arthropathy in Hereditary Hemochromatosis

et al. 2023

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Hereditary hemochromatosis (HH) is an autosomal recessive bleeding disorder characterized by tissue overload of iron. Clinical systemic manifestations in HH include liver disease, cardiomyopathy, skin pigmentation, diabetes mellitus, erectile dysfunction, hypothyroidism, and arthropathy. Arthropathy with joint pain is frequently reported at diagnosis and mainly involves the metacarpophalangeal and ankle joints, and more rarely, the hip and knee. Symptoms in ankle joints are in most cases non-specific, and they can range from pain and swelling of the ankle to deformities and joint destruction. Furthermore, the main radiological signs do not differ from those of primary osteoarthritis (OA). Limited data are available in the literature regarding treatment; surgery seems to be the gold standard for ankle arthropathy in HH. Pharmacological treatments used to maintain iron homeostasis can also be undertaken to prevent the arthropathy, but conclusive data are not yet available. This review aimed to assess the ankle arthropathy in the context of HH, including all its aspects: epidemiology, physiopathology, clinical and imaging presentation, and all the treatments available to the current state of knowledge.

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Section: Epidemiologymentioning

confidence: 99%