The Arterial Supply to the Spinal Cord of the Guinea Pig

Knox-Macaulay, H.; Morrell, M. Tessa; Potts, Daniel; Preston, T.D.

doi:10.1159/000141587

Cited by 12 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The arterial supply to the spinal cord of the guinea pig is basically similar to that in humans (Knox‐Macaulay et al . ). However, based on our study, we can conclude that the guinea pig has a somewhat different arterial arrangement compared with that found in humans.…”

Section: Discussionmentioning

confidence: 97%

“…Knox‐Macaulay et al . () studied the arterial blood supply to the spinal cord of the guinea pig. From the results obtained the frequency of occurrence of segmental arteries in the cervical region is not clear.…”

Section: Discussionmentioning

confidence: 99%

“…The arterial blood supply of the cervical spinal cord has been described in only a few studies (Knox‐Macaulay et al . ; Soutoul et al . ).…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Anatomical study of blood supply to the cervical spinal cord in the guinea pig

Mazensky

Danko

Petrovová

et al. 2014

Animal Science Journal

View full text Add to dashboard Cite

The aim of this study was to describe the arterial arrangement of the cervical spinal cord in the guinea pig. The study was carried out on 20 adult English self guinea pigs using corrosion and dissection technique. Batson's corrosion casting kit no. 17(©) was used as a casting medium. The origin of the ventral spinal artery from the left vertebral artery was found on average in 35% of the cases and from the right vertebral artery on average in 40% of the cases. The ventral spinal artery with origin from the anastomosis of two medial branches was found on average in 25% of the cases. The presence of ventral radicular branches of rami spinales entering the ventral spinal artery in the cervical region was observed in 42% of the cases on the right side and in 58% of the cases on the left side. The presence of dorsal radicular branches of rami spinales that reached the spinal cord was observed in 63% of the cases on the left side and in 37% of the cases on the right side. The number of radicular branches supplying the spinal cord is greater in guinea pig than in humans.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anatomical study of blood supply to the cervical spinal cord in the guinea pig

Mazensky

Danko

Petrovová

et al. 2014

Animal Science Journal

View full text Add to dashboard Cite

show abstract

“…Soutoul et al (1964) studied the spinal cord blood supply in several species, but the presence of the artery of Adamkiewicz, its level of origin and the frequency of the occurrence of spinal branches in the guinea pig have not been described. Knox-Macaulay et al (1960) only described the number of radicular arteries in the thoracic part of the spinal cord as five to seven and in the lumbar part noticed a great variation in the number. The ventral spinal artery was described as a vessel sometimes interrupted in its course.…”

Section: Discussionmentioning

confidence: 99%

“…The arterial supply of the thoracolumbar part of the spinal cord in guinea pigs has only been described in a few studies (Knox-Macaulay et al 1960;Soutoul et al 1964). The blood supply to the central nervous system has been described in several species of laboratory animals (Tveten 1976;Schievink et al 1988;Strauch et al 2003Strauch et al , 2007Mazensky and Danko, 2010) and in humans (Alleyne et al 1998;Nijenhuis et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Anatomical study of the arterial blood supply to the thoracolumbar spinal cord in guinea pig

et al. 2014

View full text Add to dashboard Cite

Guinea pigs are frequently used as experimental models in studies of ischemic spinal cord injury. The aim of this study was to describe the arterial blood supply to the thoracolumbar spinal cord in 20 adult English self guinea pigs using the corrosion and dissection techniques. The dorsal intercostal arteries arising from the dorsal surface of the thoracic aorta were found as follows: in eight pairs in 70% of cases, in seven pairs in 20% of cases and in nine pairs in 10% of cases. Paired lumbar arteries were present as seven pairs in all the cases. The occurrence of the ventral and dorsal branches of the spinal rami observed in the thoracic and lumbar region was higher on the left than on the right. The artery of Adamkiewicz was present in 60% of cases as a single vessel and in 40% of cases as a double vessel. On the dorsal surface of the spinal cord, we found two dorsal spinal arteries in 60% of cases and three in 40% of cases. The presence of the artery of Adamkiewicz and nearly regular segmental blood supplying the thoracolumbar part of the spinal cord in all our studied animals is the reason for using guinea pigs as a simple model of ischemic damage to the thoracolumbar part of the spinal cord.

show abstract

The systemic arterial pattern of the guinea pig: The head, thorax, and thoracic limb

Shively

Stump

1974

Am. J. Anat.

View full text Add to dashboard Cite

The systemic arterial pattern of the guinea pig was studied to determine the arrangement of the major arterial trunks and their branches. Fifty-nine specimens were examined by dissection, angiography, and corrosion casting. The arterial arrangement was found to resemble a typical mammalian pattern, although some exceptions were noted. For example, the internal carotid arteries were small and of questionable significance in the cerebral blood supply. Instead, a major portion of the blood supply to the brain appeared to be provided by the internal ophthalmic arteries. In the thoracic region, large dorsal scapular arteries originated and were distributed in part to the large fat pad in the dorsal cervical region. Also, each vertebral artery arose as two separate rami that anastomosed a few millimeters from their origin. The arterial pattern of the thoracic limb presented no unusual features.Although the guinea pig is used in many phases of biomedical research, relatively little has been reported concerning its gross morphology in general and the arterial pattern in particular. Potter et al. ('58) mapped the general arterial and venous pattern using dissection as their investigative method. Froger's study ('66) included the head, thorax, and thoracic limb. His investigative techniques included dissection, angiography, and corrosion casting. A similar study by Favre ('67) was limited to the abdomen, pelvis, and pelvic limb. Dissection studies of the abdominal aorta and its branches have been reported recently by Perneczky ('69) and in a n earlier dissertation by Luther ('23). More specific investigations include a study of the arterial supply to the mandible by Boyd et al. ('67) using dissection and corrosion casting, and a dissection study of the spinal cord supply by Knox-Macaulay et al. ('60).This study was undertaken due to the scarcity of anatomical information regarding this important research animal and the frequent disagreement of existing references. MATERIALS AND METHODSTwenty-nine males and 30 females of the species Cavia porcellus averaging 800 gm in body weight were used. Eighteen specimens were examined by gross dissection, corrosion casts were made of 13, and 28 were used in angiographic studies.All of the animals were anesthetized by intraperitoneal administration of sodium pentobarbital (Diabutal).' They were heparinized and exsanguinated and the specimens for gross dissection were embalmed with approximately 200 cm3 of 10% formalin solution. They were subsequently injected intra-arterially with red latex solution.Corrosion casts were prepared by injecting exsanguinated animals with colored vinyl acetate s~l u t i o n .~ These specimens were then placed in plastic containers, covered with concentrated HC1, and placed in a fume hood for two days. Tissue debris was washed away under running tap water leaving vinyl casts for subsequent study.Specimens for angiography were prepared by injecting exsanguinated animals with a suspension made of equal volumes of water and barium sulfate (Micropaque...

show abstract

The Arterial Supply to the Spinal Cord of the Guinea Pig

Cited by 12 publications

References 0 publications

Anatomical study of blood supply to the cervical spinal cord in the guinea pig

Anatomical study of blood supply to the cervical spinal cord in the guinea pig

Anatomical study of the arterial blood supply to the thoracolumbar spinal cord in guinea pig

The systemic arterial pattern of the guinea pig: The head, thorax, and thoracic limb

Contact Info

Product

Resources

About