The arterial circle of Willis of the mouse helps to decipher secrets of cerebral vascular accidents in the human

Okuyama, Shuhei; Okuyama, Jun; Okuyama, Junko; Tamatsu, Yuichi; Shimada, Kazuyuki; Hoshi, Hajime; Iwai, Junichi

doi:10.1016/j.mehy.2003.12.055

Cited by 28 publications

(24 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1A, B). Within the posterior portion of the cW, a PComA connection to the vertebral-basilar circulation was not identified in control embryos, consistent with the known absence or hypoplastic PComA in mice (Okuyama et al, 2004). In E13.5 control embryos, AComA segments were well-visualized (Fig.…”

Section: Resultssupporting

confidence: 70%

“…Large variations in cW organization exist among mammalian species, and in humans, suboptimal cW formation is a risk factor for ischemia and stroke in the setting of occlusive carotid artery disease (Barone et al, 1993; Hoksbergen et al, 2003; Profice et al, 2011). In contrast to the human cW with a normally preserved anterior communicating artery (AComA) and posterior communicating arteries (PComA, linking anterior and posterior cerebral circulation), the cW in mice typically lacks PComAs thereby rendering two discrete vascular distributions: the internal carotid artery (ICA)/anterior and basilar artery (BA)/posterior domains (Okuyama et al, 2004; Proweller et al, 2007). Therefore, mice largely rely on the critical AComA to maintain inter-hemispheric tissue perfusion within the anterior cerebrum.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Yang

Banerjee

Proweller

2013

Developmental Biology

View full text Add to dashboard Cite

The circle of Willis (cW) is a major arterial collateral structure interconnecting hemispheric circulation within the brain, and in humans, anatomical variation of the cW is linked to stroke risk. Our prior studies in adult mice deficient in vascular smooth muscle cell (vSMC) Notch signaling revealed altered cerebroarterial maturation and patterning, including an anatomically incompetent cW similar to human variants. However, a developmental dependency on Notch signaling for cW formation in this model remained uncharacterized. Through temporospatial embryonic analyses, we now demonstrate that cW assembly is a pre-natal process highly sensitive to vSMC Notch signals, whose absence results in delayed nascent vascular plexus formation and under-development of the cW including the key anterior communicating artery (AComA) interconnecting anterior forebrain circulation. Mutant embryos additionally feature reduced vSMC coverage, non-uniform calibers and asymmetric branching at bifurcations of the major proximal cerebral arteries. At the cellular level, a notable reduction in vascular endothelial cell proliferation exists in the region of AComA assembly despite the presence of Vegfa. Furthermore, Notch signaling-deficient vSMCs in developing cerebral vessels feature reduced Pdgfrβ and Jagged1 levels and impaired proliferation. These collective findings in the embryonic brain support studies in adult animals demonstrating a reliance on intact vSMC Notch signaling for optimal neovascular responses to angiogenic stimuli. Importantly, the new data provide unique insights into the native formation of the cW and underscore a pioneering developmental role for vSMC Notch signaling in regulating temporospatial assembly of the clinically relevant cW.

show abstract

Section: Resultssupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Yang

Banerjee

Proweller

2013

Developmental Biology

View full text Add to dashboard Cite

show abstract

“…CBF values were compared between WT, ATX, and CAT-treated ATX mice, in animals with similar HRs (409 Ϯ 10, 423 Ϯ 10, and 438 Ϯ 7 beats/min, respectively) during acquisitions. CBF was measured in a region supplied by the MCA, while arterial function/structure was assessed in the PCA, but both arteries derive from the internal carotid and form an independent domain in the circle of Willis of the mouse brain (35).…”

Section: Methodsmentioning

confidence: 99%

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr^−/−:hApoB^+/+ mice and improves cerebral blood flow

Bolduc

Baraghis

Duquette

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Endothelial dysfunction and oxidative stress contribute to the atherosclerotic process that includes stiffening of large peripheral arteries. In contrast, our laboratory previously reported a paradoxical increase in cerebrovascular compliance in LDLr(-/-):hApoB(+/+) atherosclerotic (ATX) mice (7). We hypothesized that prevention of cerebral artery endothelial dysfunction with a chronic dietary antioxidant intake would normalize the changes in cerebral artery wall structure and biomechanics and prevent the decline in basal cerebral blood flow associated with atherosclerosis. Three-month-old ATX mice were treated, or not, for 3 mo with the polyphenol (+)-catechin (CAT; 30 mg·kg(-1)·day(-1)) and compared with wild-type controls. In isolated, pressurized cerebral arteries from ATX mice, CAT prevented endothelial dysfunction (deterioration of endothelium-dependent, flow-mediated dilations; P < 0.05), the inward hypertrophic structural remodeling (increase in the wall-to-lumen ratio; P < 0.05), and the rise in cerebrovascular compliance (rightward shift of the stress-strain curve measured in passive conditions, reflecting mechanical properties of the arterial wall; P < 0.05). Doppler optical coherence tomography imaging in vivo confirmed these findings, showing that cerebral compliance was higher in ATX mice and normalized by CAT (P < 0.05). CAT also prevented basal cerebral hypoperfusion in ATX mice (P < 0.05). Active remodeling of the cerebrovascular wall in ATX mice was further suggested by the increase (P < 0.05) in pro-metalloproteinase-9 activity, which was normalized by CAT. We conclude that, by preserving the endothelial function, a chronic treatment with CAT prevents the deleterious effect of severe dyslipidemia on cerebral artery wall structure and biomechanical properties, contributing to preserving resting cerebral blood flow.

show abstract

“…Two notable examples of these anastomoses are the circle of Willis in the brain (Gray 2005), the patellar anastomosis around the knee joint (Scapinelli 1968;Gray 2005) and the arterial supply to the hand (Gray 2005). In both cases, the conventional bifurcating network of blood vessels is supplemented by cross-linking vessels that allow flow to be redirected and maintained in the event of blockage, although whether this has evolved as a redundancy or as a form of manifold to pool and distribute flow is unclear Okuyamaa et al 2006). Several engineering studies on self-healing materials Wang et al 2006;Toohey et al 2007) have used an interconnected grid of channels which provides extensive redundancy of flow paths because they are effectively porous media.…”

Section: Interconnectionmentioning

confidence: 99%

Biomimetic reliability strategies for self-healing vascular networks in engineering materials

Williams

Trask

Knights

et al. 2007

J. R. Soc. Interface.

108

View full text Add to dashboard Cite

Self-healing via a vascular network is an active research topic, with several recent publications reporting the application and optimization of these systems. This work represents the first consideration of the probable failure modes of a self-healing system as a driver for network design. The critical failure modes of a proposed self-healing system based on a vascular network were identified via a failure modes, effects and criticality analysis and compared to those of the human circulatory system. A range of engineering and biomimetic design concepts to address these critical failure modes is suggested with minimum system mass the overall design driver for high-performance systems. Plant vasculature has been mimicked to propose a segregated network to address the risk of fluid leakage. This approach could allow a network to be segregated into six separate paths with a system mass penalty of only approximately 25%. Fluid flow interconnections that mimic the anastomoses of animal vasculatures can be used within a segregated network to balance the risk of failure by leakage and blockage. These biomimetic approaches define a design space that considers the existing published literature in the context of system reliability.

show abstract

The arterial circle of Willis of the mouse helps to decipher secrets of cerebral vascular accidents in the human

Cited by 28 publications

References 27 publications

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr^−/−:hApoB^+/+ mice and improves cerebral blood flow

Biomimetic reliability strategies for self-healing vascular networks in engineering materials

Contact Info

Product

Resources

About

The arterial circle of Willis of the mouse helps to decipher secrets of cerebral vascular accidents in the human

Cited by 28 publications

References 27 publications

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Regulation of pre-natal circle of Willis assembly by vascular smooth muscle Notch signaling

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr−/−:hApoB+/+ mice and improves cerebral blood flow

Biomimetic reliability strategies for self-healing vascular networks in engineering materials

Contact Info

Product

Resources

About

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr^−/−:hApoB^+/+ mice and improves cerebral blood flow