The Arrested Development of Golden Rice: The Scientific and Social Challenges of A Transgenic Biofortified Crop

Lee, Hye-Jin; Krimsky, Sheldon

doi:10.11114/ijsss.v4i11.1941

Cited by 6 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consumption of orange cassava showed a small but significant increase in retinol and β‐carotene concentrations in plasma of Kenyan children compared to controls eating white cassava (Talsma et al ., ). Attempts at undertaking similar trials for Golden Rice have met with voracious criticism, which even led to retraction of the paper on which the claims of bioefficacy were based (Tang et al ., ; Lee & Krimsky, ).…”

Section: How Successful Has Metabolic Engineering Been In Biofortificmentioning

confidence: 99%

“…Rice biofortification in provitamin A is, of course, the prime example of this. However, the alternative of conventional breeding of biofortified rice has had little success for iron and folate, and no success with enrichment of provitamin A, although zinc‐enriched varieties of rice have been released (Lee & Krimsky, ).…”

Section: Biofortification To Address Deficiency Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Medicine is not health care, food is health care: plant metabolic engineering, diet and human health

Martin

2017

New Phytologist

105

View full text Add to dashboard Cite

Contents 699I.699II.700III.700IV.706V.707VI.714714References714 Summary Plants make substantial contributions to our health through our diets, providing macronutrients for energy and growth as well as essential vitamins and phytonutrients that protect us from chronic diseases. Imbalances in our food can lead to deficiency diseases or obesity and associated metabolic disorders, increased risk of cardiovascular diseases and cancer. Nutritional security is now a global challenge which can be addressed, at least in part, through plant metabolic engineering for nutritional improvement of foods that are accessible to and eaten by many. We review the progress that has been made in nutritional enhancement of foods, both improvements through breeding and through biotechnology and the engineering principles on which increased phytonutrient levels are based. We also consider the evidence, where available, that such foods do enhance health and protect against chronic diseases.

show abstract

Section: How Successful Has Metabolic Engineering Been In Biofortificmentioning

confidence: 99%

Section: Biofortification To Address Deficiency Diseasesmentioning

confidence: 99%

Medicine is not health care, food is health care: plant metabolic engineering, diet and human health

Martin

2017

New Phytologist

105

View full text Add to dashboard Cite

show abstract

“…Another research group in Japan found that compared to single introduction of individual genes, introduction of multiple iron homeostasis genes is more effective for iron biofortification (Masuda et al, ). However, widespread skepticism about transgenic food limits the promotion of transgenic high‐iron rice worldwide (Davidsson, ; Lee & Krimsky, ; Taheri, Azadi, & D’Haese, ).…”

Section: Ways To Improve Low Iron Levelsmentioning

confidence: 99%

Iron homeostasis in the human body and nutritional iron deficiency and solutions in China

et al. 2018

View full text Add to dashboard Cite

Iron is one of the most abundant metals on earth and is essential to most life forms. Its level is tightly regulated, since iron does not have an excretion regulation pathway, and a high toxicity of free iron can lead to tissue damage. The purpose of this review is to summarize recent knowledge, allowing a better comprehension of iron homeostasis in human body. Two main iron regulation systems including iron‐regulatory protein (IRP)–iron‐responsive element (IRE) system, and hypoxia‐inducible factor (HIF) system are highlighted. Dietary factors which impact iron absorption in human body are discussed. China has experienced rapid economic growth over the past few decades, however, significant nutritional problems remain, especially iron deficiency. Therefore, another focus of the review article is to trace the cause of iron deficiency in China and propose some possible solutions: improving dietary diversity, food iron fortification, increasing the intake of iron nutritional supplements, and iron biofortification. Practical applications Our review focuses on iron metabolism, the regulation of iron homeostasis in the human body, and how dietary food intake impacts iron absorption and metabolism, to provide an updated summary of the iron research. Iron deficiency in China and the potential reasons are discussed. One of the reasons might be related to a large amount of plant foods. We summarize recent reports of iron deficiency in China and suggest solutions to alleviate dietary iron deficiency.

show abstract

“…For instance, Golden Rice, a transgenic rice variety with enhanced pro-vitamin A to help alleviate vitamin A deficiency in developing countries, has both benefitted and suffered from media coverage. Also, the media has partly influenced the rice's current regulatory status, a regulatory limbo [44]. For as sensitive an issue as agricultural biotechnology, the media can sway the direction of public perception with unsubstantiated advocate, neutral and fair coverage or sensationalized disapproval.…”

Section: Building Public Awareness About Agricultural Biotechnologymentioning

confidence: 99%

Capacity Building for Agricultural Biotechnology in Developing Countries

Lee¹

2018

TOASJ

Self Cite

View full text Add to dashboard Cite

Introduction:Agricultural biotechnology holds a unique position in formulating food and trade policies due to its conflicting aspects: its potential to improve food security especially in developing countries, and the intense debates over its risks and unknown impacts on human health and the environment. Agricultural biotechnology, nevertheless, has been widely utilized to help enhance food security with its extensive applications.Explanation:The technology is knowledge-resource intensive, therefore reinforcing a gap between developed and developing countries. One of the critical determinants of availability and accessibility of the technology is a developing country’s own capacity. Developing countries that wish to benefit the technology should build sufficient capacity. The current study intends to review the concepts of capacity building in agricultural biotechnology, and identify areas frequently considered in need of capacity building; coordinating partnerships, making financial commitment, setting priorities, establishing a regulatory system, and building public awareness.Conclusion:While each area has its own territory, they juxtapose on one another to some extends, which can act as a virtuous or vicious cycle to facilitate or obstruct capacity building. Programs for successful capacity building in agricultural biotechnology should consider this nature.

show abstract

The Arrested Development of Golden Rice: The Scientific and Social Challenges of A Transgenic Biofortified Crop

Cited by 6 publications

References 11 publications

Medicine is not health care, food is health care: plant metabolic engineering, diet and human health

Medicine is not health care, food is health care: plant metabolic engineering, diet and human health

Iron homeostasis in the human body and nutritional iron deficiency and solutions in China

Capacity Building for Agricultural Biotechnology in Developing Countries

Contact Info

Product

Resources

About