The arrangement of chromatin in the interphase nucleus with reference to cell differentiation and repression in higher organisms

Harrisson, C.M.H.

doi:10.1016/s0040-8166(71)80001-0

Cited by 10 publications

(2 citation statements)

References 59 publications

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“…DNA methylation has been implied in regulation of gene transcription already in the late 60s (Harrisson, 1971 ; Scarano, 1971 ; Holliday and Pugh, 1975 ; Riggs, 1975 ) and often still is; although it has become clear that it likely plays a much less general role than believed originally. But why has DNA methylation become the one epigenomic mark most frequently connected to epigenetic gene silencing in the first place?…”

Section: General Concepts For Potential Functions Of Dna Modificationmentioning

confidence: 99%

DNA-Methylation: Master or Slave of Neural Fate Decisions?

Stricker

Götz

2018

Front. Neurosci.

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The pristine formation of complex organs depends on sharp temporal and spatial control of gene expression. Therefore, epigenetic mechanisms have been frequently attributed a central role in controlling cell fate determination. A prime example for this is the first discovered and still most studied epigenetic mark, DNA methylation, and the development of the most complex mammalian organ, the brain. Recently, the field of epigenetics has advanced significantly: new DNA modifications were discovered, epigenomic profiling became widely accessible, and methods for targeted epigenomic manipulation have been developed. Thus, it is time to challenge established models of epigenetic gene regulation. Here, we review the current state of knowledge about DNA modifications, their epigenomic distribution, and their regulatory role. We will summarize the evidence suggesting they possess crucial roles in neurogenesis and discuss whether this likely includes lineage choice regulation or rather effects on differentiation. Finally, we will attempt an outlook on how questions, which remain unresolved, could be answered soon.

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Section: General Concepts For Potential Functions Of Dna Modificationmentioning

confidence: 99%

DNA-Methylation: Master or Slave of Neural Fate Decisions?

Stricker

Götz

2018

Front. Neurosci.

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“…The location of the centromeres during interphase varies from report to report : some reports suggest association with the nuclear envelope (3,17) and some do not (1,7,9). In animal cells, the association of kinetochores with the nuclear membrane has been suggested by autoradiography at the light microscopic level (5) . However, the lack ofa specific means for the detection of centromeres in interphase cells prevented analysis of these organelles, especially in animal cells .…”

mentioning

confidence: 99%

Distribution of kinetochore (centromere) antigen in mammalian cell nuclei.

Möroi¹,

Hartman²,

Nakane³

et al. 1981

The Journal of Cell Biology

141

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Antigens associated with mammalian centromeres were localized at the light and electron microscopic levels using the peroxidase-labeled antibody method. The antibody used was of a type naturally occurring in the sera of patients with scleroderma . At the light microscopic level, it reacts specifically with the centromere regions of chromosomes in a variety of mammalian species and strains in discrete foci in interphase nuclei . We find that the number of foci approximates the number of chromosomes present in the various cell types . At the ultrastructural level, the antigenic foci are confirmed to lie in the kinetochore regions of each chromosome . In interphase nuclei, the antigenic foci were usually associated either with the inner surfaces of the nuclear envelope or with the nucleoli. These observations indicate that the centromere regions of the chromosomes in interphase are not randomly distributed within the nucleus but are usually fixed either to the inner surface of the nuclear envelope or to nucleoli .

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Cell Death and Reduced Proliferative Rate

ScottJr.

1977

Handbook of Teratology

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The arrangement of chromatin in the interphase nucleus with reference to cell differentiation and repression in higher organisms

Cited by 10 publications

References 59 publications

DNA-Methylation: Master or Slave of Neural Fate Decisions?

DNA-Methylation: Master or Slave of Neural Fate Decisions?

Distribution of kinetochore (centromere) antigen in mammalian cell nuclei.

Cell Death and Reduced Proliferative Rate

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