The Arg194Trp Polymorphism in the X-ray Repair Cross-Complementing Group 1 Gene as a Potential Risk Factor of Oral Cancer: A Meta-Analysis

Zhou, Chengcheng; Zhou, Yu; Li, Jing; Zhang, Yuan; Jiang, Lu; Zeng, Xin; Feng, Xiaodong; Wang, Zhi

doi:10.1620/tjem.219.43

Cited by 25 publications

(14 citation statements)

References 21 publications

(30 reference statements)

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“…Definition of asthma cases was not totally uniform, and the observed associations may simply be due to heterogeneity. In addition, the studies with small sample size appear to overestimate the true association due to the lack of sufficient power to detect such an association (40). Publication bias was also considered as a possible limitation in our study.…”

Section: Discussionmentioning

confidence: 90%

Association between Angiotensin-Converting Enzyme I/D Polymorphism and Asthma Risk: A Meta-Analysis Involving 11,897 Subjects

et al. 2012

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Section: Discussionmentioning

confidence: 90%

Association between Angiotensin-Converting Enzyme I/D Polymorphism and Asthma Risk: A Meta-Analysis Involving 11,897 Subjects

et al. 2012

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“…In particular, the codon 194 polymorphism (exon 6, base 26304 C to T, Arg to Trp) occurs in evolutionarily conserved regions, suggesting a potential functional significance. Supporting this, there are accumulating clinical researches on relations of XRCC1 polymorphisms to cancer susceptibility [22,23]. Increased susceptibility to apoptosis is implicated in the pathophysiology of AD [24].…”

Section: Introductionmentioning

confidence: 91%

Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese

Qian

Chen

et al. 2010

Journal of the Neurological Sciences

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“…The effect of changes in DNA repair genes, such as XRCC1 gene has been investigated in growing studies to elucidate possible susceptibility to various types of cancers (18,19). In the current study, the impact of XRCC1 194 C > T and 399 G > A polymorphisms were examined on the risk of differentiated thyroid carcinoma in Iranian-Azeri patients.…”

Section: Discussionmentioning

confidence: 99%

Association of Arg194Trp and Arg399Gln Polymorphisms of XRCC1 Gene and Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients

et al. 2017

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Background: The thyroid cancer (TC) is one of endocrine malignancies which contributes to more than 50% of all deaths from endocrine cancers. Gene polymorphisms including DNA repair genes such as XRCC1 (X-ray repair cross-complementing group 1) gene are thought to modify DNA repair capacity and relate to cancer risk. Objectives: The aim of the study was to detect the association between XRCC1 polymorphisms and increased risk of thyroid carcinoma among Iranian-Azeri patients. Methods: This case-control study was performed on 114 differentiated thyroid carcinoma patients and 91 normal control subjects. Single nucleotide polymorphisms (SNPs) of 194 C > T and 399 G > A of XRCC1 gene were genotyped by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP). Results: In the present study, polymorphism at codon 194 of the XRCC1 gene was not found in case and control groups (P = NC (not calculated). All of the case and control subjects were 194C/C. Unlike 399 G > A genotype (P < 0.001, OR = 0.184, CI = 0.09 -0.372), there was a positive association for 399G/G (P < 0.001, OR = 3.304, CI = 1.624 -6.780) and 399 A/A (P < 0.001, OR = 14.143, CI = 1.861 -296.277) genotypes with differentiated thyroid carcinoma. The frequency of variant 399 A allele among the cases was slightly higher than that in controls (P = 0.269, OR = 0.798, CI = 0.535 -1.190). Conclusions: Based on these results, the XRCC1 399 G > A genotype could be used as a useful molecular biomarker to predict genetic susceptibility for differentiated thyroid carcinoma in Iranian-Azeri patients.

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The Arg194Trp Polymorphism in the X-ray Repair Cross-Complementing Group 1 Gene as a Potential Risk Factor of Oral Cancer: A Meta-Analysis

Cited by 25 publications

References 21 publications

Association between Angiotensin-Converting Enzyme I/D Polymorphism and Asthma Risk: A Meta-Analysis Involving 11,897 Subjects

Association between Angiotensin-Converting Enzyme I/D Polymorphism and Asthma Risk: A Meta-Analysis Involving 11,897 Subjects

Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese

Association of Arg194Trp and Arg399Gln Polymorphisms of XRCC1 Gene and Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients

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