The area postrema in hindbrain is a central player for regulation of drinking behavior in Japanese eels

Nobata, Shigenori; Takei, Yoshiyuki

doi:10.1152/ajpregu.00056.2011

Cited by 22 publications

(10 citation statements)

References 42 publications

(64 reference statements)

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“…Thus, they serve as a window for the brain to receive chemical information, such as hormones from blood. In fact, electric lesioning of the AP impaired Ang II-induced drinking (Nobata and Takei, 2011). These data strongly suggest that Ang II acts on the AP to induce reflex swallowing, and not thirst-motivated drinking behavior (Fig.…”

Section: Differences In Regulation Of Drinkingmentioning

confidence: 66%

From Aquatic to Terrestrial Life: Evolution of the Mechanisms for Water Acquisition

Takei

2015

Zoological Science

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It is generally accepted that ancient fishes first experienced freshwater (FW), and then variably by lineage moved onto the land or re-entered the seas during evolution. As both land and sea are desiccating environments, animals must change their strategies for body fluid regulation from protecting against overhydration in FW to coping with dehydration in seawater (SW) or on land. The evolution of the mechanisms for acquisition of water surely must have accompanied these dramatic environmental changes. The major route for water acquisition is by oral drinking in terrestrial tetrapods (represented here by mammals) and in SW fishes (represented by teleosts as they are dehydrated in SW), but the regulation is contrasting between the two groups; mechanisms inducing thirst have developed in mammals, whereas inhibitory mechanisms are dominant in marine teleosts as observed in FW teleosts. Thus, the apparent difference was found not between hydrating and dehydrating habitat, but rather between terrestrial and aquatic habitats. This contrast is also reflected in regulatory hormones; dipsogenic hormones such as angiotensin II play pivotal roles in water homeostasis in mammals, whereas antidipsogenic hormones such as atrial natriuretic peptide are essential in teleosts. Imbibed water becomes body fluid only after absorption by the intestine, and there is a distinct difference in the mechanisms for water absorption between mammals and teleosts. Like regulation of drinking, we found that the inhibitory mechanisms are dominant for intestinal water absorption in teleosts. In the initial part of this short review, interesting differences in the body fluid regulation between mammals and teleosts are introduced, particularly with regard to water acquisition (drinking and intestinal absorption). Then an attempt was made to discuss the evolution of the mechanisms from the two perspectives; transitions from aquatic to terrestrial habitats and from hydrating (FW) to dehydrating (land and SW) habitats.

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Section: Differences In Regulation Of Drinkingmentioning

confidence: 66%

From Aquatic to Terrestrial Life: Evolution of the Mechanisms for Water Acquisition

Takei

2015

Zoological Science

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“…A higher plasma osmolality could be an indicator for an on-setting hypovolemia, which concentrates the blood plasma and could therefore trigger drinking. This mechanism would function as a feedback loop between endogeneous and exogeneous water additions to the stomach, likely via the action of angiostenin II, a strong dipsogen, which acts on the area postrema, as part of the renin-angiostenin system [21], [22]. The result is a combination of endogeneous and exogeneous, postprandial water additions to the stomach, which Bucking and Wood [10] considered a likely explanation for their results.…”

Section: Discussionmentioning

confidence: 97%

Isoenergetic Replacement of Fat by Starch in Diets for African Catfish (Clarias gariepinus): Effect on Water Fluxes in the Gastro Intestinal Tract

et al. 2013

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The effect of an isoenergetic replacement of dietary fat by starch, on chyme characteristics and water fluxes in the gastro intestinal tract (GIT) was assessed. Adult African catfish (Clarias gariepinus) were fed a starch (SD) or fat (FD) diet and groups of fish were dissected at 2, 5 and 8 h after the consumption of a single meal. Chyme was collected quantitatively and was analysed for osmolality and dry matter (DM) content. Postprandial water fluxes were calculated, while using yttrium oxide (Y2O3) as an inert marker to account for the absorption of DM along the GIT. The largest differences in chyme characteristics between diets were observed in the stomach and decreased towards subsequent compartments. A high initial osmotic pressure was measured in the stomach for both diets (up to 498±2 mOsm kg−1) and was likely the driver for the endogeneous water influx to this compartment. Large additions of water were recorded to the stomach and proximal intestine for both diets and absorption of water took place in the mid- and distal intestine. Interestingly, the dietary treatment had an impact on water balance in the stomach and proximal intestine of the fish, but not in the mid- and distal intestine. A strong complementary relationship suggested that 59% of the water fluxes in the proximal intestine could be explained by previous additions to the stomach. Therefore, a higher dietary inclusion of starch led to a shift in water additions from the proximal intestine to the stomach. However, the sum of water additions to the GIT was not different between diets and was on average 6.52±0.85 ml water g−1 DM. The interactions between osmoregulation and digestion, in the GIT of fed freshwater fish, deserve further attention in future research.

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“…Studies on ghrelin have focused extensively on its role in energy balance, but the effects of ghrelin on body fluid homeostasis have received far less attention. Studies in non-mammalian species (Kozaka et al 2003;Tachibana et al 2006;Nobata & Takei, 2011) and in rats (Hashimoto et al 2007(Hashimoto et al , 2010Mietlicki et al 2009) have shown that central administration of ghrelin reduces water intake in a variety of dipsogenic conditions. The behavioural regulation of fluid balance, however, involves both water intake and salt intake.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin reduces hypertonic saline intake in a variety of natriorexigenic conditions

Mietlicki

Daniels

2011

Experimental Physiology

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Ghrelin is a gut peptide that has been studied extensively for its role in food intake and energy balance. More recent studies show that ghrelin reduces water intake in rats and some nonmammalian species. Despite the importance of the regulation of NaCl intake in body fluid homeostasis, the effects of ghrelin on saline intake have not been investigated. Accordingly, we tested the effect of ghrelin on water and 1.8% NaCl intake in two-bottle test conditions with the following five stimuli that increase hypertonic saline intake: central angiotensin II administration; 24 h fluid deprivation; water deprivation followed by partial rehydration; dietary sodium deficiency; and polyethylene glycol administration combined with dietary sodium deficiency. We found that ghrelin attenuated saline intake stimulated by angiotensin II, by water deprivation followed by partial rehydration and by dietary sodium deficiency. We did not detect an effect of ghrelin on saline intake after 24 h fluid deprivation without partial rehydration or after the combination of polyethylene glycol and dietary sodium deficiency. The finding that ghrelin reduced hypertonic saline intake in some, but not all, natriorexigenic conditions mirrors the previously published findings that in one-bottle tests of drinking, ghrelin reduces water intake in only some conditions. The results provide evidence for a new role for ghrelin in the regulation of body fluid homeostasis.

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The area postrema in hindbrain is a central player for regulation of drinking behavior in Japanese eels

Cited by 22 publications

References 42 publications

From Aquatic to Terrestrial Life: Evolution of the Mechanisms for Water Acquisition

From Aquatic to Terrestrial Life: Evolution of the Mechanisms for Water Acquisition

Isoenergetic Replacement of Fat by Starch in Diets for African Catfish (Clarias gariepinus): Effect on Water Fluxes in the Gastro Intestinal Tract

Ghrelin reduces hypertonic saline intake in a variety of natriorexigenic conditions

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