The arcuate fasciculus network and verbal deficits in psychosis

Kenney, Joanne; McPhilemy, Genevieve; Scanlon, Cathy; Najt, Pablo; McInerney, Shane; Arndt, Sophia; Scherz, Elisabeth; Byrne, Fintan; Leemans, Alexander; Jeurissen, Ben; Hallahan, Brian; McDonald, Colm; Cannon, Dara M.

doi:10.1515/tnsci-2017-0018

Cited by 5 publications

(4 citation statements)

References 60 publications

(75 reference statements)

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“…Additionally, studies reported syntactic deficits in patients with primary progressive aphasia after damage of arcuate fasciculus suggesting that the role of this tract is not limited to single word processing (Wilson, Galantucci, Tartaglia, & Gorno‐Tempini, ). More recently, studies suggested a possible correlation between right hemisphere arcuate fasciculus abnormalities and deficit in VF in psychosis (Kenney et al, ).…”

Section: Discussionmentioning

confidence: 99%

White matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease

Costentin

Derrey

Gérardin

et al. 2019

Human Brain Mapping

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Decline of verbal fluency (VF) performance is one of the most systematically reported neuropsychological adverse effects after subthalamic nucleus deep brain stimulation (STN‐DBS). It has been suggested that this worsening of VF may be related to a microlesion due to the electrode trajectories. We describe the disruption of surrounding white matter tracts following electrode implantation in Parkinson's disease (PD) patients with STN‐DBS and assess whether damage of fiber pathways is associated with VF impairment after surgery. We retrospectively analyzed 48 PD patients undergoing bilateral STN DBS. The lesion mask along the electrode trajectory transformed into the MNI 152 coordinate system, was compared with white matter tract atlas in Tractotron software, which provides a probability and proportion of fibers disconnection. Combining tract‐ and atlas‐based analysis reveals that the trajectory of the electrodes intersected successively with the frontal aslant tract, anterior segment of arcuate tract, the long segment of arcuate tract, the inferior longitudinal fasciculus, the superior longitudinal fasciculus, the anterior thalamic radiation, and the fronto striatal tract. We found no association between the proportion fiber disconnection and the severity of VF impairment 6 months after surgery. Our findings demonstrated that microstructural injury associated with electrode trajectories involved white matter bundles implicated in VF networks.

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Section: Discussionmentioning

confidence: 99%

White matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease

Costentin

Derrey

Gérardin

et al. 2019

Human Brain Mapping

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“…While DTI-based fiber tractography (Mori et al 1999;Basser et al 2000) is still the most widely used approach in a clinical setting, there are nowadays more accurate approaches to compute fiber orientations, such as those based on spherical deconvolution approaches (Tournier et al 2007;Dell'Acqua et al 2010;Tax et al 2014;Jeurissen et al 2019). In regions with crossing fiber configurations, these advanced tractography techniques have been shown to provide more reliable reconstructions of white matter fiber pathways (Jeurissen et al 2011;De Schotten et al 2011;Thiebaut de Schotten et al 2012;Rojkova et al 2016;Kenney et al 2017). In this context, scalar measures derived from DTI, such as the mean diffusivity or the FA used in this work, are also non-specific in regions with multiple crossing fiber pathways and are prone to partial volume effects (Vos et al 2011(Vos et al , 2012Jeurissen et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

et al. 2019

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Aggression after military deployment is a common occurrence in veterans. Neurobiological research has shown that aggression is associated with a dysfunction in a network connecting brain regions implicated in threat processing and emotion regulation. However, aggression may also be related to deficits in networks underlying communication and social cognition. The uncinate and arcuate fasciculi are integral to these networks, thus studying potential abnormalities in these white matter connections can further our understanding of anger and aggression problems in military veterans. Here, we use diffusion tensor imaging tractography to investigate white matter microstructural properties of the uncinate fasciculus and the arcuate fasciculus in veterans with and without anger and aggression problems. A control tract, the parahippocampal cingulum was also included in the analyses. More specifically, fractional anisotropy (FA) estimates are derived along the trajectory from all fiber pathways and compared between both groups. No between-group FA differences are observed for the uncinate fasciculus and the cingulum, however parts of the arcuate fasciculus show a significantly lower FA in the group of veterans with aggression and anger problems. Our data suggest that abnormalities in arcuate fasciculus white matter connectivity that are related to self-regulation may play an important role in the etiology of anger and aggression in military veterans.

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“…Nevertheless, results of the hierarchal regression analysis indicated an association between total CRI and right pars orbitalis, a region whose functional role is still debated. Some indications of the relationship between right pars orbitalis and verbal learning and fluency has been found in patients in early stages of psychotic illness, but not in controls (Kenney et al, 2017). While there is a gap in studies considering pars orbitalis in the non-dominant hemisphere, studies including the right inferior frontal gyrus -area within which lays pars orbitalis -has been shown to be vulnerable to different types of dementia and thus might benefit from lifestyle activities or interventions (Schroeter et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Relationship between lifestyle proxies of cognitive reserve and cortical regions in older adults

Šneidere,

Zdanovskis,

Mondini

et al. 2024

Front. Psychol.

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IntroductionWith the rapid increase in the population over 65 years old, research on healthy aging has become one of the priorities in the research community, looking for a cost-effective method to prevent or delay symptoms of mild cognitive disorder or dementia. Studies indicate that cognitive reserve theory could be beneficial in this regard. The aim of this study was to investigate the potential relationship between lifestyle socio-behavioral proxies of cognitive reserve and cortical regions in adults with no subjective cognitive decline.MethodsOverall, 58 participants, aged 65–85 years, were included in the data analysis (M = 71.83, SD = 5.02, 20.7% male). Cognitive reserve proxies were measured using the Cognitive Reserve Index questionnaire, while cortical volumes were obtained with the Siemens 1.5 T Avanto MRI scanner and further mapped using the Desikan-Killiany-Tourville (DKT) Atlas. Estimated intracranial volume and age were used as covariates.ResultsThe results indicated that higher occupational complexity was associated with larger cortical volume in the left middle temporal gyrus, the left and right inferior temporal gyrus, and the left inferior parietal lobule, while a combined proxy (the total CRI score) showed a positive relationship with the volume of left middle temporal gyrus and inferior parietal lobule, and pars orbitalis in the right hemisphere.DiscussionThese results might indicate that more complex occupational activities and overall more intellectually and socially active life-style could contribute to better brain health, especially in regions known to be more vulnerable to Alzheimer’s disease.

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The arcuate fasciculus network and verbal deficits in psychosis

Cited by 5 publications

References 60 publications

White matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease

White matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease

Regions of white matter abnormalities in the arcuate fasciculus in veterans with anger and aggression problems

Relationship between lifestyle proxies of cognitive reserve and cortical regions in older adults

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