“The archeologist's career ended in ruins”: Hemispheric differences in pun comprehension in autism

Kana, Rajesh K.; Wadsworth, Heather M.

doi:10.1016/j.neuroimage.2012.04.034

Cited by 33 publications

(21 citation statements)

References 60 publications

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“…This is an important finding that not only reflects the literature in general, but also has implications for processing style and task difficulty in ASD participants. This supports many previous studies reporting atypical lateralization of language regions in ASD [Dawson et al, 1986;Eyler et al, 2012;Flagg et al, 2005;Gage et al, 2009;Herbert et al, 2002Herbert et al, , 2004Kana & Wadsworth, 2012;Kleinhans et al, Figure 4. (A) Between-group differences in brain activity during language tasks with equal group performance.…”

Section: Discussionsupporting

confidence: 91%

“…Importantly, additional analyses based on task performance indicate that increased RIFG and RSTG activity (but not left hemisphere hypo-activity) was consistently seen in language processing tasks in which the ASD group performed worse than the TD group. This is significant given that previous literature has been inconsistent, associating altered lateralization with poorer [e.g., Dawson et al, 1986], equivalent [e.g., Kana & Wadsworth, 2012;Saban-Bezalel & Mashal, 2015], and better [Redcay & Courchesne, 2008] language outcomes. However, the study that linked increased RH activation to superior language functioning [Redcay & Courchesne, 2008] examined toddlers with ASD, while others have focused primarily on older children and adults.…”

Section: Discussionmentioning

confidence: 96%

“…Findings from these studies have led to a few emerging hypotheses regarding the cortical bases of language dysfunction in ASD. These hypotheses include an increased reliance on regions involved in visual/visuospatial coding during language processing [Kana, Keller, Cherkassky, Minshew, & Just, 2006;Samson, Mottron, Soulieres, & Zeffiro, 2012], altered functional lateralization of the language network [Kana & Wadsworth, 2012;Mason, Williams, Kana, Minshew, & Just, 2008], and decreased frontal along with increased posterior language activation [Harris et al, 2006;Just, Cherkassky, Keller, & Minshew, 2004]. Nevertheless, inconsistent findings and differences in language paradigms used across studies render it unclear as to whether a dominant, reliable neural characterization of language processing exists in ASD, and further whether or not these neural differences directly relate to poorer language outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…Altered asymmetry of the language association cortex has been reported in individuals with ASD at both structural [e.g., Gage et al, 2009;Herbert et al, 2002, Herbert et al, 2004 and functional levels [e.g., Kana & Wadsworth, 2012;Kleinhans, Muller, Cohen, & Courchesne, 2008;Tesink et al, 2009]. For example, toddlers with ASD were shown to have significantly greater right hemisphere (RH) activation, relative to control participants, in a speech perception task [Eyler, Pierce, & Courchesne, 2012;Redcay & Courchesne, 2008] suggesting early origins of hemispheric differences.…”

Section: Introductionmentioning

confidence: 99%

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Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

et al. 2016

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Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N = 328; TD: N = 324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. Autism Res 2016, 9: 1046-1057. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

et al. 2016

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“…Deficits in integrating the spoken word with non-verbal communication (Kana 2012), poor recognition and interpretation of facial expressions, low self-esteem, inability to resolve conflict and poor recognition of likely consequences can contribute to social isolation, manipulation, exploitation and maltreatment of the individual.…”

Section: Socially Inap Propriate Behaviourmentioning

confidence: 99%

Autism spectrum disorder in adults: clinical features and the role of the psychiatrist

Garland

O'Rourke

Robertson

2013

Adv. psychiatr. treat

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SummaryAutism spectrum disorders (ASDs) are lifelong conditions. Although not all adults with ASD require psychiatric input, general adult psychiatrists increasingly find themselves responsible for the care of adults with the disorder. This may present a new and unique challenge to them. Here, we summarise the core clinical features of ASD; discuss appropriate diagnostic practice; review the principles of management; and identify key educational, social care and voluntary services for adults with ASD in the UK.

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The Impact of Reading Intervention on Brain Responses Underlying Language in Children With Autism

2015

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Deficits in language comprehension have been widely reported in children with autism spectrum disorders (ASD), with behavioral and neuroimaging studies finding increased reliance on visuospatial processing to aid in language comprehension. However, no study to date, has taken advantage of this strength in visuospatial processing to improve language comprehension difficulties in ASD. This study used a translational neuroimaging approach to test the role of a visual imagery-based reading intervention in improving the brain circuitry underlying language processing in children with ASD. Functional magnetic resonance imaging (MRI), in a longitudinal study design, was used to investigate intervention-related change in sentence comprehension, brain activation, and functional connectivity in three groups of participants (age 8-13 years): an experimental group of ASD children (ASD-EXP), a wait-list control group of ASD children (ASD-WLC), and a group of typically developing control children. After intervention, the ASD-EXP group showed significant increase in activity in visual and language areas and right-hemisphere language area homologues, putamen, and thalamus, suggestive of compensatory routes to increase proficiency in reading comprehension. Additionally, ASD children who had the most improvement in reading comprehension after intervention showed greater functional connectivity between left-hemisphere language areas, the middle temporal gyrus and inferior frontal gyrus while reading high imagery sentences. Thus, the findings of this study, which support the principles of dual coding theory [Paivio 2007], suggest the potential of a strength-based reading intervention in changing brain responses and facilitating better reading comprehension in ASD children.

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“The archeologist's career ended in ruins”: Hemispheric differences in pun comprehension in autism

Cited by 33 publications

References 60 publications

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

Autism spectrum disorder in adults: clinical features and the role of the psychiatrist

The Impact of Reading Intervention on Brain Responses Underlying Language in Children With Autism

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