The Arbuscular Mycorrhizal Fungus Glomus viscosum Improves the Tolerance to Verticillium Wilt in Artichoke by Modulating the Antioxidant Defense Systems

Villani, Alessandra; Tommasi, Franca; Paciolla, Costantino

doi:10.3390/cells10081944

Cited by 27 publications

(22 citation statements)

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“…Oxidative stress is typically caused by an imbalance between prooxidants and antioxidants, contributing to gut diseases, consequently, intestinal barrier dysfunction [ 19 , 42 ]. The overproduction of ROS or decreased antioxidant capacity usually caused oxidative stress, leading to severe cell injury and/or cell death in humans or animals [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

et al. 2021

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Deoxynivalenol (DON) is a threatening mycotoxin primarily present in the agricultural environment, especially in food commodities and animal forages, and exerts significant global health hazards. Lycopene (LYC) is a potent antioxidant carotenoid mainly present in tomatoes and other fruits with enormous health benefits. The present study was designed to ascertain whether LYC could protect DON-induced intestinal epithelium oxidative injury by regulating Keap1/Nrf2 signaling in the intestine of mice. A total of forty-eight mice were randomly distributed into four groups (n = 12), Control (CON), 10 mg/kg BW LYC, 3 mg/kg BW DON, and 3 mg/kg DON + 10 mg/kg LYC BW (DON + LYC). The experimental groups were treated by intragastric administration for 11 days. Our results showed that LYC significantly increased average daily feed intake (ADFI), average daily gain (ADG), and repaired intestinal injury and barrier dysfunction, as evident by increased trans-epithelial electrical resistance (TEER) and decreased diamine oxidase (DAO) activity, as well as up-regulated tight junction proteins (occludin, claudin-1) under DON exposure. Furthermore, LYC treatment stabilized the functions of intestinal epithelial cells (Lgr5, PCNA, MUC2, LYZ, and Villin) under DON exposure. Additionally, LYC alleviated DON-induced oxidative stress by reducing ROS and MDA accumulation and enhancing the activity of antioxidant enzymes (CAT, T-SOD, T-AOC, and GSH-Px), which was linked with the activation of Nrf2 signaling and degradation of Keap1 expression. Conclusively, our findings demonstrated that LYC protects intestinal epithelium from oxidative injury by modulating the Keap1/Nrf2 signaling pathway under DON exposure. These novel findings could lead to future research into the therapeutic use of LYC to protect the DON-induced harmful effects in humans and/or animals.

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Section: Discussionmentioning

confidence: 99%

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

et al. 2021

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“…Activity staining was performed by incubating the gels in specific buffers. APX, CAT, GR were detected as described by Paciolla et al (2016), DHAR according to Loi et al (2020a, b) while SOD by Villani et al (2021). For POD activity staining, the gel was incubated in Tris-acetate 0.1 M, pH 5 containing H 2 O 2 0.32 mM and 1-methoxynaphthol 1 mM.…”

Section: Native-pagementioning

confidence: 99%

Cell death induced by mycotoxin fumonisin B1 is accompanied by oxidative stress and transcriptional modulation in Arabidopsis cell culture

et al. 2022

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Key message Fumonisin B1 induces rapid programmed cell death in Arabidopsis cells, oxidative and nitrosative bursts, and differentially modulates cell death responsive genes. Glutathione is the main antioxidant involved in the stress response. Abstract Fumonisin B1 (FB1) is a fungal toxin produced by Fusarium spp. able to exert pleiotropic toxicity in plants. FB1 is known to be a strong inducer of the programmed cell death (PCD); however, the exact mechanism underling the plant–toxin interactions and the molecular events that lead to PCD are still unclear. Therefore, in this work, we provided a comprehensive investigation of the response of the model organism Arabidopsis thaliana at the nuclear, transcriptional, and biochemical level after the treatment with FB1 at two different concentrations, namely 1 and 5 µM during a time-course of 96 h. FB1 induced oxidative and nitrosative bursts and a rapid cell death in Arabidopsis cell cultures, which resembled a HR-like PCD event. Different genes involved in the regulation of PCD, antioxidant metabolism, photosynthesis, pathogenesis, and sugar transport were upregulated, especially during the late treatment time and with higher FB1 concentration. Among the antioxidant enzymes and compounds studied, only glutathione appeared to be highly induced in both treatments, suggesting that it might be an important stress molecule induced during FB1 exposure. Collectively, these findings highlight the complexity of the signaling network of A. thaliana and provide information for the understanding of the physiological, molecular, and biochemical responses to counteract FB1-induced toxicity.

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“…Vì vậy, việc sử dụng các biện pháp thân thiện với môi trường để bảo vệ mùa màng chống lại côn trùng gây hại và các tác nhân gây bệnh đã và đang thu hút được nhiều nghiên cứu quan tâm. Trong đó, nấm rễ AM được xem như một nhân tố kiểm soát sinh học đối với nhiều tác nhân gây bệnh quan trọng trên thực vật như Verticillium dahlia, Phytophthora parasitica, Fusarium oxysporum, Phythium aphanidermatum, Neonectria ditissima, Potato virus Y (PVY), Tobacco mosaic virus (TMV), Cucumber green mottle mosaic virus (CGMMV) và bệnh tuyến trùng nematodes [59][60][61].…”

Section: E Nấm Am Và Tác Nhân Gây Bệnhunclassified

“…Nấm rễ AM còn cho thấy có khả năng đối kháng tốt với nấm gây bệnh héo rũ Verticillium spp. Loại nấm này có đa dạng ở các loại cây chủ và gây chết đối với các cây chủ của nó [59,61]. Các chủng nấm Glomus etunicatum, G. intraradices và G. versiforme đều được chứng minh là có khả năng làm giảm mức độ nghiêm trọng của bệnh héo rũ trên cây bông do nấm V. dahlia [65].…”

Section: E Nấm Am Và Tác Nhân Gây Bệnhunclassified

“…Nghiên cứu này cho thấy, cây bông ở nghiệm thức có chủng nấm G. intraradices làm giảm ở mức thấp nhất tỉ lệ nghiêm trọng của bệnh (mức độ nghiêm trọng của bệnh được tính dựa trên chỉ số của tổng số lá bị bệnh héo, úa, hoại tử trên tổng số lá của mỗi cây) so với cây ở nghiệm thức đối chứng không chủng nấm rễ và các nghiệm thức chủng nấm rễ G. etunicatum và G. versiforme [65]. Villani et al [61] cũng chứng minh rằng khi có sự hiện diện của nấm rễ AM G. viscosum, mức độ nghiêm trọng của bệnh héo rũ do nấm V. dahlia giảm trên cây atisô (Cynara scolymus L.). Ở nghiệm thức có chủng nấm rễ V. dahlia, mức độ nghiêm trọng của bệnh trên lá cây đạt 3,9, trong khi ở nghiệm thức chủng nấm rễ và nấm bệnh chỉ đạt 1,6 (thang mức độ nghiêm trọng của bệnh là từ 0-4, trong đó 0: không có triệu chứng héo; 1: lá úa giữa các gân lá ở các lá phía dưới; 2: hoại tử trung bình và làm rụng lá phía dưới; 3: hoại tử lá nghiêm trọng và rụng lá; và 4: rụng lá nghiêm trọng kèm theo còi cọc, úa lá và hoại tử các lá còn lại) [61].…”

Section: E Nấm Am Và Tác Nhân Gây Bệnhunclassified

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Potential Benefits of Arbuscular Mycorrhiza Fungi in Sustainable Agricultural Cultivation

Hai

Huynh

2022

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The Arbuscular Mycorrhiza fungi have a mutualistic relationship with 80% of terrestrial plants. Arbuscular Mycorrhiza fungi are considered as a biofertilizer source because of their positive effects on plant growth andproductivity They can help to reduce the amount of chemical fertilizers by up to 50% due to their ability in enhancing crops to uptake mineral nutrients efficently such as nitrogen, phosphorus, potassium, calcium, zinc. . . thereby increasing crop yield. Moreover, this endosymbiotic fungus also shows its potential as a biopesticide due to its ability to biologically antagonize a wide range of fungi, viruses, and nematodes, which cause diseases on plants. Besides, Arbuscular Mycorrhiza fungi also help plants to resist to abiotic streeses such as drought, salinity, and toxicity of heavy metals. The glomalin compound secreted by mycorrhizal fungi has the ability tobind tiny soil particles together to form a stable soil structure and aggregates, helping to improve soil qualitỵ Thus, Arbuscular Mycorrhiza fungi have a high use potential in sustainable agricultural development under the context of climate change such as drought, salinity intrusion.

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The Arbuscular Mycorrhizal Fungus Glomus viscosum Improves the Tolerance to Verticillium Wilt in Artichoke by Modulating the Antioxidant Defense Systems

Cited by 27 publications

References 87 publications

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling

Cell death induced by mycotoxin fumonisin B1 is accompanied by oxidative stress and transcriptional modulation in Arabidopsis cell culture

Potential Benefits of Arbuscular Mycorrhiza Fungi in Sustainable Agricultural Cultivation

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