The Arabidopsis RNA-Binding Protein FCA Requires a Lysine-Specific Demethylase 1 Homolog to Downregulate FLC

Liu, Fuquan; Quesada, Vı́ctor; Crevillén, Pedro; Bäurle, Isabel; Świeżewski, Szymon; Dean, Caroline

doi:10.1016/j.molcel.2007.10.018

Cited by 287 publications

(355 citation statements)

References 65 publications

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“…Our data support such a two-phase transition and suggest that RCD1 functions in the transition from inflorescence production to flower production, perhaps through control of FLC expression. FLC expression is controlled on many levels, including epigenetic modification of chromatin (Dennis and Peacock, 2007), transcriptional activation , and mRNA processing (Liu et al, 2007;Xing et al, 2008). Poly(ADP-ribosyl)ation has been implicated in all three of these processes in other systems (Hakme et al, 2008;Ji and Tulin, 2009;Quenet et al, 2009); therefore, it is difficult to assign RCD1 a specific function in the control of FLC expression without further experimentation.…”

Section: Control Of Reproductive Growth By Rcd1 and Sro1mentioning

confidence: 99%

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

2009

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RADICAL-INDUCED CELL DEATH1 (RCD1) and SIMILAR TO RCD ONE1 (SRO1) are the only two proteins encoded in the Arabidopsis (Arabidopsis thaliana) genome containing both a putative poly(ADP-ribose) polymerase catalytic domain and a WWE protein-protein interaction domain, although similar proteins have been found in other eukaryotes. Poly(ADP-ribose) polymerases mediate the attachment of ADP-ribose units from donor NAD + molecules to target proteins and have been implicated in a number of processes, including DNA repair, apoptosis, transcription, and chromatin remodeling. We have isolated mutants in both RCD1 and SRO1, rcd1-3 and sro1-1, respectively. rcd1-3 plants display phenotypic defects as reported for previously isolated alleles, most notably reduced stature. In addition, rcd1-3 mutants display a number of additional developmental defects in root architecture and maintenance of reproductive development. While single mutant sro1-1 plants are relatively normal, loss of a single dose of SRO1 in the rcd1-3 background increases the severity of several developmental defects, implying that these genes do share some functions. However, rcd1-3 and sro1-1 mutants behave differently in several developmental events and abiotic stress responses, suggesting that they also have distinct functions. Remarkably, rcd1-3; sro1-1 double mutants display severe defects in embryogenesis and postembryonic development. This study shows that RCD1 and SRO1 are at least partially redundant and that they are essential genes for plant development.

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Section: Control Of Reproductive Growth By Rcd1 and Sro1mentioning

confidence: 99%

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

2009

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“…Thus, FCA and FPA, two proteins with RRM-type RNA-binding domains, control 3′-end formation and alternative polyadenylation of antisense RNAs at the FLC locus (35,36). FCA regulation of FLC requires FLD, a histone demethylase, linking RNA processing to chromatin changes (37). FCA also interacts with the mRNA 3′-end processing factor FY, and this interaction is required for FLC down-regulation (38).…”

Section: Resultsmentioning

confidence: 99%

MSI4/FVE interacts with CUL4–DDB1 and a PRC2-like complex to control epigenetic regulation of flowering time in Arabidopsis

Pazhouhandeh

Molinier

Berr

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

157

161

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Flowering at the right time is crucial to ensure successful plant reproduction and seed yield and is dependent on both environmental and endogenous parameters. Among the different pathways that impinge on flowering, the autonomous pathway promotes floral transition independently of day length through the repression of the central flowering repressor FLOWERING LOCUS C (FLC). FLC blocks floral transition by repressing flowering time integrators such as FLOWERING LOCUS T (FT). MSI4/FVE is a key regulator of the autonomous pathway that reduces FLC expression. Here we report that the MSI4 protein is a DDB1 and CUL4-associated factor that represses FLC expression through its association with a CLF-Polycomb Repressive Complex 2 (PRC2) in Arabidopsis. Thus, the lack of MSI4 or decreased CUL4 activity reduces H3K27 trimethylation on FLC, but also on its downstream target FT, resulting in increased expression of both genes. Moreover, CUL4 interacts with FLC chromatin in an MSI4-dependant manner, and the interaction between MSI4 and CUL4-DDB1 is necessary for the epigenetic repression of FLC. Overall our work provides evidence for a unique functional interaction between the cullin-RING ubiquitin ligase (CUL4-DDB1 MSI4 ) and a CLF-PRC2 complex in the regulation of flowering timing in Arabidopsis.I n the model plant Arabidopsis thaliana, floral transition is regulated by changes in day length and exposure of plants to long periods of low temperature by two well-defined genetic pathways, called photoperiod and vernalization, respectively (reviewed in refs. 1-3). In addition to environmentally controlled pathways, the gibberellic acid-dependent and the autonomous pathways are controlled by internal cues, ensuring flowering independently of external signals. However, input signals that might control the activities of these pathways are currently unknown. These different pathways converge to regulate several target genes at the transcriptional level, resulting in a complex network of flowering-time regulation. Among target genes, FLOWERING LOCUS C (FLC) encodes a MADS-box transcription factor, which quantitatively blocks the floral transition by repressing the expression of the floral integrator genes SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1/AGAMOUS-LIKE 20 (SOC1/AGL20) and FLOWERING LOCUS T (FT). FLC transcriptional regulation is at the convergence of the vernalization pathway that represses FLC after exposure to low temperatures and the autonomous pathway, which constitutively represses FLC (2, 3). In turn, FLC repression results in floral integrator (i.e., FT and SOC1/AGL20) activation, leading to the induction of expression of floral-primordium-identity genes such as APETALA 1 (AP1) and LEAFY (LFY) and floralorgan-identity genes such as AGAMOUS (AG) and AP3, promoting the transition from a vegetative to an inflorescence meristem (1-3).Mutants in the autonomous pathway flower very late when grown under either long-day (LD) or short-day (SD) photoperiods (4). Cloning of the autonomous pathway gene FVE (5, 6) revealed a WD40 ...

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“…The autonomous pathway is comprised of a series of activities linking RNA processing of the FLC antisense transcripts with the H3K4 demethylase FLOWERING LOCUS D (Liu et al 2007(Liu et al , 2010 Fig. 2) (Wood et al 2006).…”

Section: Memory Of Winter Involves Polycomb Silencingmentioning

confidence: 99%

Epigenetic Regulation in Plant Responses to the Environment

Baulcombe

Dean

2014

Cold Spring Harbor Perspectives in Biology

211

176

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SUMMARYIn this article, we review environmentally mediated epigenetic regulation in plants using two case histories. One of these, vernalization, mediates adaptation of plants to different environments and it exemplifies processes that are reset in each generation. The other, virus-induced silencing, involves transgenerationally inherited epigenetic modifications. Heritable epigenetic marks may result in heritable phenotypic variation, influencing fitness, and so be subject to natural selection. However, unlike genetic inheritance, the epigenetic modifications show instability and are influenced by the environment. These two case histories are then compared with other phenomena in plant biology that are likely to represent epigenetic regulation in response to the environment. Outline

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The Arabidopsis RNA-Binding Protein FCA Requires a Lysine-Specific Demethylase 1 Homolog to Downregulate FLC

Cited by 287 publications

References 65 publications

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

MSI4/FVE interacts with CUL4–DDB1 and a PRC2-like complex to control epigenetic regulation of flowering time in Arabidopsis

Epigenetic Regulation in Plant Responses to the Environment

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