The aqueous Triton X-100 – dodecyltrimethylammonium bromidemicellar mixed system. Experimental results and thermodynamic analysis

Serafini, Patricio; Fernández-Leyes, Marcos D.; Sánchez, Félix; Pereyra, Rodolfo G.; Schulz, Erica P.; Durand, Guillermo; Schulz, Pablo C.; Ritacco, Hernán

doi:10.1016/j.colsurfa.2018.09.027

Cited by 11 publications

(11 citation statements)

References 49 publications

(86 reference statements)

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“…The hydrodynamic radius of the 5 mM TTAB in aqueous solution is obtained to be in the range of 3.8–5.7 nm with a zeta potential of 16.35 ± 0.73 mV. These values are in good agreement with those reported earlier. , Similarly, the values of the hydrodynamic radius of 1 mM TX-100 (7.3–9.4) nm is in close agreement with that reported earlier. The mixed micelles of TTAB and TX-100 are observed to be smaller (2.7–4.1 nm) than the individual TTAB or TX-100 micelles .…”

Section: Resultssupporting

confidence: 91%

“…These values are in good agreement with those reported earlier. 15,60 Similarly, the values of the hydrodynamic radius of 1 mM TX- 15 The partitioning of kanamycin, gentamicin, azithromycin, or erythromycin in TTAB or TX-100 micelles either does not result in a significant variation in the hydrodynamic radius or leads to the strengthening of the micelles as reflected by the small d H upon drug partitioning (Table 3).…”

Section: ■ Introductionmentioning

confidence: 99%

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Correlating the Properties of Antibiotics with the Energetics of Partitioning in Colloidal Self-Assemblies and the Effect on the Binding of a Released Drug with a Target Protein

Judy

Kishore

2021

Langmuir

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The bioavailability of drugs and the monitoring of efficient dosage requires drug delivery through suitable vehicles. The partitioning characteristics of the drugs in the delivery vehicles is determined by their molecular features and structure. A quantitative understanding of the partitioning of drugs into delivery media and its subsequent release and binding to the target protein is essential to deriving guidelines for rational drug design. We have studied the partitioning of aminoglycosides and macrolide antibiotic drugs kanamycin, gentamicin, azithromycin, and erythromycin in cationic, nonionic, and the mixture of cationic and nonionic self-assemblies. The quantitative aspects of drug partitioning followed by the monitoring of its interaction with target model protein bovine serum albumin on subsequent release have been performed by using a combination of spectroscopy and high-sensitivity calorimetry. The mechanisms of partitioning have been analyzed on the basis of the values of standard molar enthalpy, entropy, the Gibbs free-energy change, and stoichiometry of interaction. The integrity of the binding sites and the effects of the components of the self-assemblies and the released drug on the serum albumin were analyzed by using differential scanning calorimetry and circular dichroism spectroscopy. The thermodynamic signatures of drug partitioning and subsequent binding to target protein have enabled an in-depth correlation of the structure− property−energetics relationships which are crucial for the broader objective of rational drug design.

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Section: Resultssupporting

confidence: 91%

Section: ■ Introductionmentioning

confidence: 99%

Correlating the Properties of Antibiotics with the Energetics of Partitioning in Colloidal Self-Assemblies and the Effect on the Binding of a Released Drug with a Target Protein

Judy

Kishore

2021

Langmuir

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“…This negative deviation indicates the existence of interactions between two surfactants in the mixed aggregates. The addition of small amounts of TX100 led to a reduction in the electrostatic self-repulsion between the rhamnolipids head groups [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic Solubilization of Phenanthrene by Mixed Micelles Composed of Biosurfactants and a Conventional Non-Ionic Surfactant

Liu

Wang

2020

Molecules

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This study investigated the solubilization capabilities of rhamnolipids biosurfactant and synthetic surfactant mixtures for the application of a mixed surfactant in surfactant-enhanced remediation. The mass ratios between Triton X-100 and rhamnolipids were set at 1:0, 9:1, 3:1, 1:1, 1:3, and 0:1. The ideal critical micelle concentration values of the Triton X-100/rhamnolipids mixture system were higher than that of the theoretical predicted value suggesting the existence of interactions between the two surfactants. Solubilization capabilities were quantified in term of weight solubilization ratio and micellar-water partition coefficient. The highest value of the weight solubilization ratio was detected in the treatment where only Triton X-100 was used. This ratio decreased with the increase in the mass of rhamnolipids in the mixed surfactant systems. The parameters of the interaction between surfactants and the micellar mole fraction in the mixed system have been determined. The factors that influence phenanthrene solubilization, such as pH, ionic strength, and acetic acid concentration have been discussed in the paper. The aqueous solubility of phenanthrene increased linearly with the total surfactant concentration in all treatments. The mixed rhamnolipids and synthetic surfactants showed synergistic behavior and enhanced the solubilization capabilities of the mixture, which would extend the rhamnolipids application.

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“…The high surfactant regime range is 400-650 µg L −1 [3], while surfactants with concentrations of 800 µg L −1 and above are observed in natural slicks [14]. Surfactants exert wave-damping effects on ocean surfaces, even at low concentrations (50-300 µg L −1 ) [15,16], and are also known to form micelles in bulk water.…”

Section: Introductionmentioning

confidence: 99%

“…The formation of micelles by surfactants occurs when the surfactant molecules at a particular concentration can no longer accumulate in the monolayer at the surface [16]. Since surfactants prefer to adsorb to liquid surfaces, they lower the surface tension of the liquid [17].…”

Section: Introductionmentioning

confidence: 99%

Effects of Natural and Artificial Surfactants on Diffusive Boundary Dynamics and Oxygen Exchanges across the Air–Water Interface

Adenaya

Haack

Stolle

et al. 2021

Oceans

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Comparing measurements of the natural sea surface microlayer (SML) and artificial surface films made of Triton-X-100 and oleyl alcohol can provide a fundamental understanding of diffusive gas fluxes across the air–water boundary layers less than 1 mm thick. We investigated the impacts of artificial films on the concentration gradients and diffusion of oxygen (O2) across the SML, the thickness of the diffusive boundary layer (DBL), and the surface tension levels of natural seawater and deionized water. Natural and artificial films led to approximately 78 and 81% reductions in O2 concentration across the surfaces of natural seawater and deionized water, respectively. The thicknesses of the DBL were 500 and 350 µm when natural SML was added on filtered and unfiltered natural seawater, respectively, although the DBL on filtered seawater was unstable, as indicated by decreasing thickness over time. Triton-X-100 and oleyl alcohol at a concentration of 2000 µg L−1 in deionized water persistently increased the DBL thickness values by 30 and 26% over a period of 120 min. At the same concentration, Triton-X-100 and oleyl alcohol decreased the surface tension of deionized water from ~72 mN m−1 to 48 and 38 mN m−1, respectively; 47% recovery was recorded after 30 min with Triton-X-100, although low surface tension persisted for 120 min with oleyl alcohol. The critical micelle concentration values of Triton-X-100 ranged between 400 and 459 µg L−1. We, therefore, suggest that Triton-X-100 resembles natural SML because the reduction and partial recovery of the surface tension of deionized water with the surfactant resembles the behavior observed for natural slicks. Temperature and salinity were observed to linearly decrease the surface tension levels of natural seawater, artificial seawater, and deionized water. Although several factors leading to O2 production and consumption in situ are excluded, experiments carried out under laboratory-controlled conditions are useful for visualizing fine-scale processes of O2 transfer from water bodies through the surface microlayer.

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The aqueous Triton X-100 – dodecyltrimethylammonium bromidemicellar mixed system. Experimental results and thermodynamic analysis

Cited by 11 publications

References 49 publications

Correlating the Properties of Antibiotics with the Energetics of Partitioning in Colloidal Self-Assemblies and the Effect on the Binding of a Released Drug with a Target Protein

Correlating the Properties of Antibiotics with the Energetics of Partitioning in Colloidal Self-Assemblies and the Effect on the Binding of a Released Drug with a Target Protein

Synergistic Solubilization of Phenanthrene by Mixed Micelles Composed of Biosurfactants and a Conventional Non-Ionic Surfactant

Effects of Natural and Artificial Surfactants on Diffusive Boundary Dynamics and Oxygen Exchanges across the Air–Water Interface

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