The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-β1 signaling pathway

Yao, Yao; Yang, Jie; Wang, Dawei; Zhou, Fengjiao; Cai, Xueting; Lü, Wei; Hu, Chunping; Gu, Zhenhua; Qian, Shan; Guan, Xiaoxiang; Cao, Peng

doi:10.1016/j.phymed.2013.06.004

Cited by 20 publications

(26 citation statements)

References 22 publications

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“…The TGF-β signaling pathway was shown to be involved in renal damage (67–69). TGF-β-induced renal damage has been associated with: i) tubular cell death (68,70,71); ii) epithelial mesenchymal transition (72,73); and iii) fibroblast proliferation (74,75).…”

Section: Discussionmentioning

confidence: 99%

Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation

Yiang

Chou

et al. 2014

Molecular Medicine Reports

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Acetaminophen (APAP), is a safe analgesic and antipyretic drug at therapeutic dose, and is widely used in the clinic. However, high doses of APAP can induce hepatotoxicity and nephrotoxicity. Most studies have focused on high-dose APAP-induced acute liver and kidney injury. So far, few studies have investigated the effects of the therapeutic dose (1/10 of the high dose) or of the low dose (1/100 of the high dose) of APAP on the cells. The aim of this study was to investigate the cellular effects of therapeutic- or low-dose APAP treatment on hepatoma cells and kidney fibroblasts. As expected, high-dose APAP treatment inhibited while therapeutic and low-dose treatment did not inhibit cell survival of kidney tubular epithelial cells. In addition, therapeutic-dose treatment induced an increase in the H2O2 level, activated the caspase-9/-3 cascade, and induced cell apoptosis of hepatoma cells. Notably, APAP promoted fibroblast proliferation, even at low doses. This study demonstrates that different cellular effects are exerted upon treatment with different APAP concentrations. Our results indicate that treatment with the therapeutic dose of APAP may exert an antitumor activity on hepatoma, while low-dose treatment may be harmful for patients with fibrosis, since it may cause proliferation of fibroblasts.

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Section: Discussionmentioning

confidence: 99%

Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation

Yiang

Chou

et al. 2014

Molecular Medicine Reports

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“…Increasing evidence supports that LT could suppress high glucose-induced vascular inflammatory process via inhibition of reactive oxygen species (ROS) and NF-jB activation in human umbilical vein endothelial cells [19]. In addition, the aqueous extract of LT was found to reduce streptozotocin-induced diabetic renal damage [20]. In this current study, we aimed to investigate the protective effect of LT on DR.…”

Section: Introductionmentioning

confidence: 94%

“…The contents of caffeic acid, luteolin-7-O-b-D glucoside and rosmarinic acid in LT were measured by a Waters Acquity UPLC system coupled with a Waters Micromass Quattro Premier tandem quadrupole mass spectrometer as described in the previous studies [20,21].…”

Section: Uplc/ms Analysismentioning

confidence: 99%

The protective effects of lycopus lucidus turcz in diabetic retinopathy and its possible mechanisms

Liu

Bhuvanagiri

2019

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of the present study was to investigate the effect of Lycopus lucidus Turcz (LT) on diabetic retinopathy (DR) and its underlying mechanisms. SD rats and human retinal microvascular endothelial cells (HRECs) were applied for establishment DR model. HE and TUNEL staining were used to evaluate the pathological changes and apoptosis of retinal ganglion cells. Additionally, retinal vessels were detected by immunofluorescence staining with CD31 and VEGF. The function of BRB was observed using Evans blue. Moreover, the oxidative stress, inflammation and angiogenesis associated factors were measured respectively. The expression of p38-MAPK/NF-jB signalling proteins were detected by Western blot. The results demonstrated that pathological changes and retinal optic disc cells apoptosis in retinas of diabetic rats, both of which were reduced in the LT-treated group. And LT treatment attenuated the levels of oxidative stress, inflammation and angiogenesis factors. Importantly, the expression levels of p-p38, pERK , p-JNK and NF-jB were decreased. After treatment with TNF-a combined with LT, the levels of inflammatory factors were decreased but higher than the negative control. Taken together, the results suggested that LT treatment is of therapeutic benefit by ameliorating oxidative stress, inflammation and angiogenesis of DR via p38-MAPK/NF-jB signaling pathway.

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“…Researchers have showed that luteolin exhibits anti-inflammatory, antioxidant, and anti-carcinogenic activities [16–18]. Recent studies have shown that luteolin has a renal protective effect via attenuation of oxidative stress and inflammation in cisplatin-induced AKI in animals [19,20]. …”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice

Xin

et al. 2016

Med Sci Monit

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BackgroundSepsis can cause serious acute kidney injury in bacterium-infected patients, especially in intensive care patients. Luteolin, a bioactive flavonoid, has renal protection and anti-inflammatory effects. This study aimed to investigate the effect and underlying mechanism of luteolin in attenuating lipopolysaccharide (LPS)-induced renal injury.Material/MethodsICR mice were treated with LPS (25 mg/kg) with or without luteolin pre-treatment (40 mg/kg for three days). The renal function, histological changes, degree of oxidative stress, and tubular apoptosis in these mice were examined. The effects of luteolin on LPS-induced expression of renal tumor necrosis factor-α (TNF-α), NF-κB, MCP-1, ICAM-1, and cleaved caspase-3 were evaluated.ResultsLPS resulted in rapid renal damage of mice, increased level of blood urea nitrogen (BUN), and serum creatinine (Scr), tubular necrosis, and increased oxidative stress, whereas luteolin pre-treatment could attenuate this renal damage and improve the renal functions significantly. Treatment with LPS increased TNF-α, NF-κB, IL-1β, cleaved caspase-3, MCP-1, and ICAM-1 expression, while these disturbed expressions were reversed by luteolin pre-treatment.ConclusionsThese results indicate that luteolin ameliorates LPS-mediated nephrotoxicity via improving renal oxidant status, decreasing NF-κB activation and inflammatory and apoptosis factors, and then disturbing the expression of apoptosis-related proteins.

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The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-β1 signaling pathway

Cited by 20 publications

References 22 publications

Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation

Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation

The protective effects of lycopus lucidus turcz in diabetic retinopathy and its possible mechanisms

Protective Effects of Luteolin on Lipopolysaccharide-Induced Acute Renal Injury in Mice

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