The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats

Goorani, Samaneh; Zhaleh, Mohsen; Zangeneh, Akram; Koohi, Mohammad Kazem; Rashidi, Khodabakhsh; Moradi, Rohallah; Zangeneh, Mohammad Mahdi

doi:10.1007/s00580-018-2852-9

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…During the establishment of the GU model, acetic acid inflicted damage on gastric mucosal tissues and cells, leading to inflammation. As the number of damaged cells increased, more immune cells were stimulated to release inflammatory factors, resulting in chronic inflammation that expedited ulcer formation [ 39 , 40 , 41 ]. In addition, excessive reactive oxygen species (ROS) played a significant role in accelerating GU formation.…”

Section: Discussionmentioning

confidence: 99%

Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats

Zhang,

Xu,

Chen

et al. 2024

Molecules

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Dendrobium officinale is an important edible and medicinal plant, with the Dendrobium officinale polysaccharide (DOP) being its primary active constituent, known for its diverse biological activities. In this study, DOP was extracted and characterized for its structural properties. The potential of DOP to ameliorate gastric ulcers (GUs) was investigated using an acetic-acid-induced GU model in rats. The results demonstrated that DOP exerted a multifaceted protective effect against GU, mitigating the deleterious impact on food intake and body weight in rats. DOP exhibited its protective action by attenuating cellular damage attributed to oxidative stress and inflammatory reactions mediated by enhanced activities of SOD, GSH, and GSH-PX, coupled with a downregulation in the expression of pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α. Furthermore, DOP effectively inhibited apoptosis in gastric mucosa cells of acetic-acid-induced GU rat models and facilitated the self-repair of damaged tissues. Remarkably, the DOP-200 and DOP-400 groups outperformed omeprazole in reducing the expression of IL-6 and malondialdehyde (MDA) in tissues, as well as IL-1β, IL-6, and TNF-α in serum. These groups also exhibited an improved expression of SOD in tissues and SOD, GSH, and GSH-PX in serum. A Western blot analysis of gastric mucosa demonstrated that the DOP-200 and DOP-400 groups significantly reduced the expression of NF-κBp65, phosphorylated NF-κBp65, FoxO3a, and Bim. The observed antagonism to GU appeared to be associated with the NF-κB cell pathway. Additionally, qRT-PCR results indicate that DOP reduced the mRNA transcription levels of IL-6, and TNF-α, which shows that the healing of GU is related to the reduction in the inflammatory reaction by DOP. However, the expression of EGF and VEGF decreased, suggesting that the mechanism of DOP inhibiting GU may not be directly related to EGF and VEGF, or there is an uncertain competitive relationship between them, so further research is needed.

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Section: Discussionmentioning

confidence: 99%

Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats

Zhang,

Xu,

Chen

et al. 2024

Molecules

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“…Sonuçta G. glabra'nın tüm dozlarda omeprazolle eşit düzeyde gastrik ve duedonal ülseri iyileştirdiği raporlanmıştır ve bitkinin triterpen ve flavonoidlerden zengin olduğu ve gastroduodenal koruyucu etkisinin bu sebeple olduğu öne sürülmüştür. 16 Klinik Çalışmalar: H. pylori testi pozitif olan 60 hasta ile yapılan klinik çalışmada hastalar 2 gruba ayrılmış, ilk gruba metronidazol, amoksisilin, omeprazol ve meyan kökü içeren bir tablet olan D-Reglis (Iran Darouk Pharmaceuticals, İran), ikinci gruba ise meyan kökü yerine bizmut subsalisilat uygulanmıştır. Çalışma sonucunda meyan kökü verilen grubunun eradikasyon oranı %67 iken, verilmeyen grubunun %57 olduğu bulunmuştur.…”

Section: Kimyasal Bileşenlerunclassified

Evaluation of Some Medicinal and Aromatic Plants Used in the Treatment of Peptic Ulcer in Terms of Pharmacognosy: Traditional Review

HESEKİ,

ÇINAR KOÇ,

KONUKLUGİL

2024

J Lit Pharm Sci

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ÖZET Fitoterapi terimi, tıbbi bitkilerin hastalıkların tedavi edilmesi ya da tedaviye yardımcı olması amacıyla kullanılması olarak tanımlanmakta ve günümüzde birçok hastalığın tedavi sürecine destek olmak amacıyla kullanılmaktadır. Peptik ülser, dünya popülasyonunun %5-10'unda yaşam boyunca en az bir kere görülen, mide, duodenum veya özofagusta rastlanan, asit veya pepsinden kaynaklanan bir doku kaybı olarak tanımlanmaktadır. Uygulanan konvansiyonel tedavinin yan etkileri, tedavi maliyeti, Helicobacter pylori'nin antimikrobiyal ilaçlara karşı direnç göstermesi, ülserasyonların tekrarlaması gibi sebeplerden dolayı alternatif tedavi yöntemleri ilgi çekmiş ve tıbbi bitkilerin kullanıldığı tamamlayıcı tedaviler araştırılmaya başlanmıştır. Peptik ülser hastalığının önlemesinde ve/veya tedavi edilmesinde, geleneksel olarak kullanılan bitkiler içinde üzerinde klinik çalışma yapılmış bazı bitkiler Glycyrrhiza glabra, Nigella sativa, Zingiber officinale; üzerinde in vivo çalışma yapılmış bazı bitkiler Allium sativum, Camellia sinensis, Carum carvi, Foeniculum vulgare, Hypericum perforatum, Laurus nobilis, Matricaria chamomilla, Momordica charantia, Melissa officinalis, Mentha piperita, Olea europaea, Thymus vulgaris bu derleme için seçilip değerlendirilmiştir. Bu değerlendirme sonucunda, tıbbi bitkilerin üzerinde yapılan bilimsel araştırmaların sayısında artış olmasına rağmen klinik çalışmalarının kapsamlı şekilde yapılmaması, etki mekanizmalarının aydınlatılmaması, yan etki profillerinin detaylı olarak raporlanmaması gibi eksiklikler nedeniyle tıbbi bitkilerden elde edilen güvenilir preparatların üretilmesinin zorlaştığı belirlenmiştir. Bu eksikliklerin giderilmesiyle birlikte yeni geliştirilecek preparat ve ilaçların hem doğal kaynaklı ilaç hammaddeleri hakkındaki çalışmalara hem de insan sağlığına önemli ölçüde etkisi olacağı düşünülmektedir.Anah tar Ke li me ler: Fitoterapi; tibbi bitkiler; peptik ülser ABS TRACT The term phytotherapy is defined as the use of medicinal plants for the treatment of diseases or to assist treatment and is used today to support the treatment process of many diseases. Peptic ulcer is defined as a tissue loss caused by acid or pepsin, occurring in the stomach, duodenum, or esophagus at least once in a lifetime in 5-10% of the world population. Alternative treatment methods have attracted attention due to the side effects of conventional treatment, cost of treatment, resistance of Helicobacter pylori to antimicrobial drugs, recurrence of ulcerations and complementary therapies using medicinal plants have begun to be investigated. Some plants that have been clinically studied in the traditionally used plants for the prevention and/or treatment of peptic ulcer disease Glycyrrhiza glabra, Nigella sativa, and Zingiber officinale; some plants on which in vivo studies have been conducted are Allium sativum, Camellia sinensis, Carum carvi, Foeniculum vulgare, Hypericum perforatum, Laurus nobilis, Matricaria chamomilla, Momordica charantia, Melissa officinalis, Mentha piperita, Olea europaea, Thymus ...

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“…[3] In medicine, G. glabra is used due to its splenoprotective, gastroprotective, nephroprotective, hepatoprotective, hematoprotective, immunoprotective, anti-inflammatory, anti-anemic, antioxidant, antibacterial, antifungal, anti-parasitic, antiviral, anticarcinogenic, cutaneous wound healing, oestrogenic, antidepressive, sedative, and neuroprotective effects. [4] In Iranian traditional medicine especially in Kurdish traditional medicine, the people use G. glabra for the treatment of blood disorders such as thrombocytopenia, hemolytic anemia, iron deficiency, hematotoxicity, and sometimes for leukemia. [4][5][6] Recently, the medicinal researchers have synthesized many metallic nanoparticles using medicinal plants for increasing the therapeutic potentials of these plants.…”

Section: Introductionmentioning

confidence: 99%

“…[ 4 ] In Iranian traditional medicine especially in Kurdish traditional medicine, the people use G. glabra for the treatment of blood disorders such as thrombocytopenia, hemolytic anemia, iron deficiency, hematotoxicity, and sometimes for leukemia. [ 4–6 ] Recently, the medicinal researchers have synthesized many metallic nanoparticles using medicinal plants for increasing the therapeutic potentials of these plants. [ 1 ] So, it is supposed that if G. glabra is combined with metallic nanoparticles, the above remedial properties will increase.…”

Section: Introductionmentioning

confidence: 99%

Introducing a novel chemotherapeutic drug formulated by iron nanoparticles for the clinical trial studies

Ahmeda

Wang

et al. 2020

Applied Organom Chemis

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In recent years, the experiments have revealed that plants raise the cytotoxicity and anticancer potentials of iron nanoparticles against several cell lines especially tumor cell lines. In the present study, we formulated a modern drug by iron nanoparticles (FeNPs) containing Glycyrrhiza glabra L leaf for the treatment of acute lymphoblastic leukemia. Characterization of FeNPs was done by TEM, FE-SEM, UV-Vis, and FT-IR. FE-SEM and TEM images revealed an average diameter of 11-18 nm for the nanoparticles. UV-Vis revealed an absorption band at 298 nm that is related to the surface plasmon resonance of FeNPs. FT-IR results offered antioxidant compounds in the nanoparticles were the sources of reducing power, reducing iron ions to FeNPs. MTT assay was used on normal (HUVEC) and acute lymphoblastic leukemia (MOLT-3, CEM/C2, TALL-104, and CCRF-CEM) cell lines for comparing the anti-acute lymphoblastic leukemia properties of FeCl 3 , G. glabra, and FeNPs. Iron nanoparticles had very low cell viability dose-dependently against MOLT-3, CEM/C2, TALL-104, CCRF-CEM cell lines without any cytotoxicity on the HUVEC cell line. The best result of cytotoxicity property of FeNPs against the above cell lines was seen in the case of CCRF-CEM cell line. These nanoparticles can be administrated in humans for the treatment of acute lymphoblastic leukemia after confirming in the in vivo and clinical trials.

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The aqueous extract of Glycyrrhiza glabra effectively prevents induced gastroduodenal ulcers: experimental study on Wistar rats

Cited by 6 publications

References 37 publications

Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats

Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats

Evaluation of Some Medicinal and Aromatic Plants Used in the Treatment of Peptic Ulcer in Terms of Pharmacognosy: Traditional Review

Introducing a novel chemotherapeutic drug formulated by iron nanoparticles for the clinical trial studies

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