2013
DOI: 10.1016/j.ejps.2013.02.006
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The applications of Vitamin E TPGS in drug delivery

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Cited by 448 publications
(286 citation statements)
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“…[18][19][20][21] Other than being an excellent emulsifier, TPGS itself has been reported to have anticancer efficacy because of its function as an inhibitor of P-glycoprotein to surmount multidrug resistance in tumor cells. [22][23][24] In this work, the TPGS-b-PCL copolymer was synthesized and characterized. The genistein-loaded NPs were prepared with a modified nanoprecipitation method instead of solvent extraction/evaporation method and characterized.…”
Section: Introductionmentioning
confidence: 99%
“…[18][19][20][21] Other than being an excellent emulsifier, TPGS itself has been reported to have anticancer efficacy because of its function as an inhibitor of P-glycoprotein to surmount multidrug resistance in tumor cells. [22][23][24] In this work, the TPGS-b-PCL copolymer was synthesized and characterized. The genistein-loaded NPs were prepared with a modified nanoprecipitation method instead of solvent extraction/evaporation method and characterized.…”
Section: Introductionmentioning
confidence: 99%
“…In the present study, as shown above, the incorporation of nicotine in both lamellar and cubic phases enhanced the in vitro permeation and penetration in the skin. A possible explanation may be the action of Vitamin E-TPGS and IPM as penetration enhancers (Guo et al, 2013;Aggarwal, Goindi, Mehta, 2012;Engelbrecht et al, 2012). Indeed, it has been reported that Vitamin E acts as a permeation enhancer by intercalating within the lipid bilayer region of the SC, promoting changes of membrane permeability (Trivedi, Krill, Fort, 1995), while IPM acts as penetration enhancer by introducing phase separation and perturbing the multilamellar lipid assembly (Engelbrecht et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…They are named as modulators and they exert effect by interacting membrane lipids and inhibiting P-glycoprotein (MDR protein) [22,23] . So cell membrane is the very important target of MDR modulators.…”
Section: Discussionmentioning
confidence: 99%