The applications of polysaccharides in dentistry

Yang, Zhijing; Liu, Weiwei; Liu, Huimin; Li, Rong; Lu, Chao; Kan, Shaoning; Hao, Ming; Wang, Dongxu

doi:10.3389/fbioe.2022.970041

Cited by 3 publications

(2 citation statements)

References 97 publications

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“…157,158 PRP is the best source of natural growth factors, without the risk of disease transmission and rejection. 159 This technique has been clinically verified and is approaching maturity. So far, PRP treatment has been performed by This journal is © The Royal Society of Chemistry 2023 traditional injection.…”

Section: Osteoarthritismentioning

confidence: 94%

Transdermal drug delivery via microneedles for musculoskeletal systems

Zheng¹,

Xie²,

Ling³

et al. 2023

J. Mater. Chem. B

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Section: Osteoarthritismentioning

confidence: 94%

Transdermal drug delivery via microneedles for musculoskeletal systems

Zheng¹,

Xie²,

Ling³

et al. 2023

J. Mater. Chem. B

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“…In addition, there are many advantages of polysaccharides, including good biodegradability and biocompatibility and few side effects [ 17 , 18 ]. Polysaccharides are utilized extensively in the food and pharmaceutical industries as emulsifiers, adjuvants for vaccines, and materials to treat oral diseases [ 19 , 20 , 21 ]. Therefore, polysaccharides can be regarded as a promising strategy for the prevention and treatment of DM.…”

Section: Introductionmentioning

confidence: 99%

Updated Progress on Polysaccharides with Anti-Diabetic Effects through the Regulation of Gut Microbiota: Sources, Mechanisms, and Structure–Activity Relationships

Zhang,

Wang,

Zhang

et al. 2024

Pharmaceuticals

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Diabetes mellitus (DM) is a common chronic metabolic disease worldwide. The disturbance of the gut microbiota has a complex influence on the development of DM. Polysaccharides are one type of the most important natural components with anti-diabetic effects. Gut microbiota can participate in the fermentation of polysaccharides, and through this, polysaccharides regulate the gut microbiota and improve DM. This review begins by a summary of the sources, anti-diabetic effects and the gut microbiota regulation functions of natural polysaccharides. Then, the mechanisms of polysaccharides in regulating the gut microbiota to exert anti-diabetic effects and the structure–activity relationship are summarized. It is found that polysaccharides from plants, fungi, and marine organisms show great hypoglycemic activities and the gut microbiota regulation functions. The mechanisms mainly include repairing the gut burrier, reshaping gut microbiota composition, changing the metabolites, regulating anti-inflammatory activity and immune function, and regulating the signal pathways. Structural characteristics of polysaccharides, such as monosaccharide composition, molecular weight, and type of glycosidic linkage, show great influence on the anti-diabetic activity of polysaccharides. This review provides a reference for the exploration and development of the anti-diabetic effects of polysaccharides.

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Chitosan as a biomaterial for the prevention and treatment of dental caries: antibacterial effect, biomimetic mineralization, and drug delivery

Qu,

Ma,

et al. 2023

Front. Bioeng. Biotechnol.

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Dental caries is a chronic, progressive disease caused by plaque, influenced by multiple factors and can damage the hard tissues of the teeth. In severe cases, it can also lead to the onset and development of other oral diseases, seriously affecting patients’ quality of life. The creation of effective biomaterials for the prevention and treatment of dental caries has become one of the relentless goals of many researchers, with a focus on inhibiting the production of cariogenic plaque and retaining beneficial bacteria, guiding and promoting the reconstruction of dental hard tissues, and delaying the progression of existing caries. Chitosan is a natural cationic polymer extracted from the shells of crustaceans and shellfish. Since its discovery, chitosan has shown to have various biological functions such as antibacterial, biomimetic mineralization, drug delivery, etc., making it one of the most promising biopolymers for new caries prevention and materials of prostheses. Therefore, this article provides an overview of the anti-caries applications of chitosan, which mainly covers the basic research on the application of chitosan in caries prevention and treatment since 2010, with a focus on categorizing and summarizing the following characteristics of chitosan as a caries prevention material, including its antibacterial effect, biomimetic mineralization effect and delivery ability of caries prevention drugs and vaccines. It also explores the limitations of current research on chitosan as a caries prevention biomaterial and the difficulties that need to be focused on and overcome in the future to provide theoretical reference for the clinical implementation of chitosan as a caries prevention biomaterial.

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The applications of polysaccharides in dentistry

Cited by 3 publications

References 97 publications

Transdermal drug delivery via microneedles for musculoskeletal systems

Transdermal drug delivery via microneedles for musculoskeletal systems

Updated Progress on Polysaccharides with Anti-Diabetic Effects through the Regulation of Gut Microbiota: Sources, Mechanisms, and Structure–Activity Relationships

Chitosan as a biomaterial for the prevention and treatment of dental caries: antibacterial effect, biomimetic mineralization, and drug delivery

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