The Applications of Dimethyl Sulfoxide as a One‐Carbon Source in Organic Synthesis

Li, Chong-Liang; Wu, Xiao‐Feng

doi:10.1002/9783527831883.ch37

Cited by 1 publication

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“…[11] However, these reagents release harmful waste and have an effect on the environment as well as human health. Other single-carbon reagents such as trimethyl orthoformate, [12] dimethyl carbonate, [13] dimethyl sulfoxide, [14] and methyl radical sources [15] are also feasible for the methylation process. Green and sustainable methylation reagents like CO 2 , [2b] methanol, [8b,16] and formic [16] acid were found to be the ideal C1 reactants in N-methylation reactions, especially for the synthesis of structurally diverse functionalized products.…”

Section: Introductionmentioning

confidence: 99%

Recent Trends in Upgrading of CO₂ as a C1 Reactant in N‐ and C‐Methylation Reactions

et al. 2022

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Carbon dioxide (CO 2 ) capture and conversion from renewable resources have recently emerged as a viable alternative to the synthesis of core chemicals. Despite the fact that CO 2 fixation is limited due to its thermodynamic stability and kinetic inertness, researchers are becoming increasingly interested in developing novel routes with the use of CO 2 in synthetic organic chemistry, and the pace of advancements in this field is accelerating. In particular, the development of benign N-and C-methylation reactions employing CO 2 as a C1 synthon instead of conventional methylation reagents would enable the release of lower amounts of waste leading to more sustainable chemical industry. This review presents recent new strategies for the chemical transformation of CO 2 and its incorporation into Nor C-based nucleophiles to provide access to the respective methylamines and methylated (hetero)arenes. Finally, existing limitations in NÀ H, and CÀ H bond activation techniques and future prospects are also discussed. We believe these methodologies will provide a handy reference to the chemists for synthesizing a vast range of methylated molecules in shorter steps by utilizing CO 2 as an advantageous single-carbon source.

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Section: Introductionmentioning

confidence: 99%

Recent Trends in Upgrading of CO₂ as a C1 Reactant in N‐ and C‐Methylation Reactions

et al. 2022

View full text Add to dashboard Cite

show abstract

The Applications of Dimethyl Sulfoxide as a One‐Carbon Source in Organic Synthesis

Cited by 1 publication

References 49 publications

Recent Trends in Upgrading of CO₂ as a C1 Reactant in N‐ and C‐Methylation Reactions

Recent Trends in Upgrading of CO₂ as a C1 Reactant in N‐ and C‐Methylation Reactions

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The Applications of Dimethyl Sulfoxide as a One‐Carbon Source in Organic Synthesis

Cited by 1 publication

References 49 publications

Recent Trends in Upgrading of CO2 as a C1 Reactant in N‐ and C‐Methylation Reactions

Recent Trends in Upgrading of CO2 as a C1 Reactant in N‐ and C‐Methylation Reactions

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Recent Trends in Upgrading of CO₂ as a C1 Reactant in N‐ and C‐Methylation Reactions

Recent Trends in Upgrading of CO₂ as a C1 Reactant in N‐ and C‐Methylation Reactions