The Applications of 1,4‐Dioxane, THF, and Ethers as Versatile Building Blocks in Organic Synthesis

TBHP/KI-Promoted Annulation of Anilines, Ethers, and Elemental Sulfur: Access to 2-Aryl-, 2-Heteroaryl-, or 2-Alkyl-Substituted Benzothiazoles

“…Ethers, such as diethyl ether, tetrahydrofuran, etc., are cheap and readily available solvents in most labs and are versatile building blocks in organic synthesis . During recent years, ethers have been reported as sources of alkyls through the C–O bond cleavage of ethers, but the application in the construction of heterocycles is still rare (Scheme a) .…”

Annulation of 1-(2-Aminoaryl)pyrroles, Ethers with Elemental Sulfur To Give 1,3,6-Benzothiadiazepine Derivatives through Double C–S Bond Formation and C–O Cleavage of Ethers

“…Ethers, such as THF, 1,4-dioxane, diethyl ether, etc., have been widely used as solvents for organic reactions or as extracting agents for separation of organic compounds. Furthermore, the ethers are versatile reagents in organic synthesis via cleavage of C–H, C–O, or C–C bonds . Numerous cross-coupling reactions involving the cleavage of the α-C­(sp 3 )–H bond of ethers have been developed over the past years, , which were successfully used in the formation of a C–S bond .…”

An Approach to Quinoline-Fused Imidazopyridines via CDC of Ethers with Imidazopyridines under Metal-Free Conditions

“…Ethers are widely used as solvents or extracting agents in organic synthesis. As cheap and easily available reagents, the application of ethers as reactants has also aroused much interest . Many reports focused on the cleavage of an α-C­(sp 3 )–H bond of ethers via cross-dehydrogenative coupling (CDC) to construct a C–C bond, e.g., the C–H functionalization of arenes or heteroarenes.…”