The application of thromboelastogram in detection of indexes of antiplatelet therapy for coronary heart disease

Abstract

Background: This study aims to explore the application value of thromboelastogram (TEG) in antiplatelet therapy in coronary artery intervention.Methods: A retrospective analysis of 90 cases of coronary interventional treatment was conducted in our hospital from January 2010 to January 2012. Cases were divided into three groups, according to the kind of coronary heart disease: angina pectoris (AP) group (30 cases), unstable angina pectoris (UAP) group (30 cases) and acute myocardial infarction (AMI) group (30 cases). TEG changes in patients between the three groups were analyzed.Results: The differences in international normalized ratio (INR) and activated partial thromboplastin time (APTT) indexes among the three groups of patients were statistically significant (P<0.05), but these indexes significantly decreased in the AMI group. Furthermore, D-D, Fgb, Angle and MA indexes significantly increased in the UAP and AMI groups, compared with the AP group; while TEG regular parameter K and R values were markedly reduced. Coagulation graphics were higher in the UAP and AMI groups than in the AP group (χ 2 =4.261, 3.908; P<0.05), suggesting that the difference was statistically significant. In 11 cases of ischemic events, arachidonic acid (AA)-induced platelet inhibition rate was 63.63%, while adenosine diphosphate (ADP)-induced platelet inhibition rate was 36.37% (χ 2 =5.026; P<0.05); suggesting that ADP-induced platelet inhibition rate was markedly reduced. This is the main risk of ischemic events within three months after percutaneous coronary intervention. Conclusions:The detection of indexes of antiplatelet therapy in coronary artery intervention is helpful for antiplatelet medication, thus can effectively reduce the incidence of ischemic events.

Influence of Lower Extremity Deep Venous Thrombosis in Cerebral Infarction on Coagulation Index and Thromboelastogram and Its Risk Factors

“…In the research of Pandey et al [ 23 ], the prediction ability of TEG on bleeding after central venous catheter insertion in patients with liver cirrhosis was explored, and it was found that the AUC of K value in predicting bleeding of patients was 0.694, and that of MA in predicting bleeding-free AUC was 0.719, which was sensitive to coagulopathy. This also indicated that monitoring these patients by TEG can prepare for antiplatelet or antithrombotic therapy in time once the patients are found to be in a high coagulation state, and the blood transfusion scheme can be improved by predicting the bleeding situation of patients during operation [ 24 ]. At the end of the study, we also analyzed the risk factors of LEDVT in patients with cerebral infarction through the logistics regression equation and found that FIB, angle, and MA values were the risk factors of patients while R and K values were the protective factors.…”

Short-term efficacy of ticagrelor in acute ST-segment elevation myocardial infarction patients undergoing an emergency percutaneous coronary intervention

“…Thromboelastography (TEG) is a new type of detection method that can evaluate the whole process of platelet aggregation in the blood [24, 25]. It has the following advantages over LTA.…”

Analysis of Platelet Function from Thromboelastography Examination in Patients with Single and Multiple Antiplatelet Therapy after Percutaneous Coronary Intervention in Dr. Saiful Anwar Malang

“…The results of this examination can be used to predict the bleeding situation, hypercoagulation, and fibrinolysis. In patients undergoing antiplatelet therapy, the examination of platelet function with TEG is useful for monitoring antiplatelet therapy's effectiveness and determining the choice of antiplatelet drugs to be given to each patient (Swallow et al, 2006;Zhao et al, 2016).…”